Literature DB >> 35604558

Unraveling Pathways of Health and Lifespan with Integrated Multiomics Approaches.

Miguel A Aon1,2, Michel Bernier1, Rafael de Cabo3.   

Abstract

Distinct and shared pathways of health and lifespan can be untangled following a concerted approach led by experimental design and a rigorous analytical strategy where the confounding effects of diet and feeding regimens can be dissected. In this chapter, we use integrated analysis of multiomics (transcriptomics-metabolomics) data in liver from mice to gain insight into pathways associated with improved health and survival. We identify a unique metabolic hub involving glycine-serine-threonine metabolism at the core of lifespan, and a pattern of shared pathways related to improved health.
© 2022. This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.

Entities:  

Keywords:  Computational systems biology; Diet; Gene and functional ontologies; Healthy aging; Integrated pathway analysis; Time-restricted feeding; Topology-based pathway network analysis

Mesh：

Substances：

Year:  2022        PMID： 35604558     DOI： 10.1007/978-1-0716-1831-8_9

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  9 in total

1.  Daily Fasting Improves Health and Survival in Male Mice Independent of Diet Composition and Calories.

Authors:  Sarah J Mitchell; Michel Bernier; Julie A Mattison; Miguel A Aon; Tamzin A Kaiser; R Michael Anson; Yuji Ikeno; Rozalyn M Anderson; Donald K Ingram; Rafael de Cabo
Journal:  Cell Metab       Date:  2018-09-06       Impact factor: 27.287

2.  Using MetaboAnalyst 4.0 for Comprehensive and Integrative Metabolomics Data Analysis.

Authors:  Jasmine Chong; David S Wishart; Jianguo Xia
Journal:  Curr Protoc Bioinformatics       Date:  2019-12

3.  Meta-analysis of gene expression in the mouse liver reveals biomarkers associated with inflammation increased early during aging.

Authors:  Janice S Lee; William O Ward; Hongzu Ren; Beena Vallanat; Gretchen J Darlington; Eun-Soo Han; Juan C Laguna; James H DeFord; John Papaconstantinou; Colin Selman; J Christopher Corton
Journal:  Mech Ageing Dev       Date:  2012-06-13       Impact factor: 5.432

4.  Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study.

Authors:  Julie A Mattison; George S Roth; T Mark Beasley; Edward M Tilmont; April M Handy; Richard L Herbert; Dan L Longo; David B Allison; Jennifer E Young; Mark Bryant; Dennis Barnard; Walter F Ward; Wenbo Qi; Donald K Ingram; Rafael de Cabo
Journal:  Nature       Date:  2012-09-13       Impact factor: 49.962

5.  Caloric restriction delays disease onset and mortality in rhesus monkeys.

Authors:  Ricki J Colman; Rozalyn M Anderson; Sterling C Johnson; Erik K Kastman; Kristopher J Kosmatka; T Mark Beasley; David B Allison; Christina Cruzen; Heather A Simmons; Joseph W Kemnitz; Richard Weindruch
Journal:  Science       Date:  2009-07-10       Impact factor: 47.728

6.  Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice.

Authors:  Sarah J Mitchell; Julio Madrigal-Matute; Morten Scheibye-Knudsen; Evandro Fang; Miguel Aon; José A González-Reyes; Sonia Cortassa; Susmita Kaushik; Marta Gonzalez-Freire; Bindi Patel; Devin Wahl; Ahmed Ali; Miguel Calvo-Rubio; María I Burón; Vincent Guiterrez; Theresa M Ward; Hector H Palacios; Huan Cai; David W Frederick; Christopher Hine; Filomena Broeskamp; Lukas Habering; John Dawson; T Mark Beasley; Junxiang Wan; Yuji Ikeno; Gene Hubbard; Kevin G Becker; Yongqing Zhang; Vilhelm A Bohr; Dan L Longo; Placido Navas; Luigi Ferrucci; David A Sinclair; Pinchas Cohen; Josephine M Egan; James R Mitchell; Joseph A Baur; David B Allison; R Michael Anson; José M Villalba; Frank Madeo; Ana Maria Cuervo; Kevin J Pearson; Donald K Ingram; Michel Bernier; Rafael de Cabo
Journal:  Cell Metab       Date:  2016-06-14       Impact factor: 27.287

7.  PAGE: parametric analysis of gene set enrichment.

Authors:  Seon-Young Kim; David J Volsky
Journal:  BMC Bioinformatics       Date:  2005-06-08       Impact factor: 3.169

8.  Caloric restriction improves health and survival of rhesus monkeys.

Authors:  Julie A Mattison; Ricki J Colman; T Mark Beasley; David B Allison; Joseph W Kemnitz; George S Roth; Donald K Ingram; Richard Weindruch; Rafael de Cabo; Rozalyn M Anderson
Journal:  Nat Commun       Date:  2017-01-17       Impact factor: 14.919

9.  Untangling Determinants of Enhanced Health and Lifespan through a Multi-omics Approach in Mice.

Authors:  Miguel A Aon; Michel Bernier; Sarah J Mitchell; Clara Di Germanio; Julie A Mattison; Margaux R Ehrlich; Ricki J Colman; Rozalyn M Anderson; Rafael de Cabo
Journal:  Cell Metab       Date:  2020-05-14       Impact factor: 31.373
  9 in total

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