Sana Niazi1, Jorge Alio Del Barrio2,3, Azad Sanginabadi4, Farideh Doroodgar5, Cyrus Alinia6, Alireza Baradaran-Rafii1,7, Feaizollah Niazi1, Hossein Mohammad-Rabei1,5, Mohammad Mehdi Sadoughi1,5, Jorge L Alio2,3. 1. Department of Ophthalmology, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran. 2. Vissum, Alicante 03016, Spain. 3. Division of Ophthalmology, Universidad Miguel Hernández, Alicante 03016, Spain. 4. Department of Optometry, Iran University of Medical Sciences, Tehran 1544914599, Iran. 5. Negah Specialty Ophthalmic Research Center, Shahid Beheshti University of Medical Science, Tehran 1544914599, Iran. 6. Department of Public Health, School of Public Health, Urmia University of Medical Sciences, Urmia, West Azerbaijan 5714783734, Iran. 7. Department of ophthalmology, University of South Florida, Tampa, Florida 33617, USA.
Abstract
AIM: To compare the visual results of non-topography-guided and topography-guided photorefractive keratectomy (PRK) applying sequential and simultaneous corneal cross-linking (CXL) treatment for keratoconus. METHODS: Interventional and comparative prospective study. Sixty-nine eyes (36 patients) suffering from keratoconus (stages 1 Amsler-Krumeich classification) were divided into four groups: sequential topography-guided photorefractive keratectomy with CXL, simultaneous topography-guided photorefractive keratectomy with CXL, simultaneous non-topography guided photorefractive keratectomy with CXL, and sequential non-topography guided photorefractive keratectomy with CXL. The main outcome measures were pre- and postoperative uncorrected distance visual acuity (UDVA), best corrected distance visual acuity (CDVA), manifest refraction, contrast sensitivity, and keratometry. RESULTS: All analyzed visual, contrast sensitivity, and refractive parameters showed a significant improvement in the four groups (all P<0.05). A noticeable improvement was seen in keratometry in all the groups, and a remarkable difference was observed between topography-guided groups in comparison to non-topography-guided groups (P<0.05). Interestingly, the improvement in all parameters showed a degree of stability to the end of the follow-up. CONCLUSION: The treatment priorities in all four groups are safety, efficacy, and predictability in the correction of the sphero-cylindrical errors in mild and moderate keratoconus. No significant differences among groups in the recorded objective outcomes were found. International Journal of Ophthalmology Press.
AIM: To compare the visual results of non-topography-guided and topography-guided photorefractive keratectomy (PRK) applying sequential and simultaneous corneal cross-linking (CXL) treatment for keratoconus. METHODS: Interventional and comparative prospective study. Sixty-nine eyes (36 patients) suffering from keratoconus (stages 1 Amsler-Krumeich classification) were divided into four groups: sequential topography-guided photorefractive keratectomy with CXL, simultaneous topography-guided photorefractive keratectomy with CXL, simultaneous non-topography guided photorefractive keratectomy with CXL, and sequential non-topography guided photorefractive keratectomy with CXL. The main outcome measures were pre- and postoperative uncorrected distance visual acuity (UDVA), best corrected distance visual acuity (CDVA), manifest refraction, contrast sensitivity, and keratometry. RESULTS: All analyzed visual, contrast sensitivity, and refractive parameters showed a significant improvement in the four groups (all P<0.05). A noticeable improvement was seen in keratometry in all the groups, and a remarkable difference was observed between topography-guided groups in comparison to non-topography-guided groups (P<0.05). Interestingly, the improvement in all parameters showed a degree of stability to the end of the follow-up. CONCLUSION: The treatment priorities in all four groups are safety, efficacy, and predictability in the correction of the sphero-cylindrical errors in mild and moderate keratoconus. No significant differences among groups in the recorded objective outcomes were found. International Journal of Ophthalmology Press.
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