| Literature DB >> 35589828 |
Soyeon Kim1,2,3,4, Kiwon Kim5, Mi Yeong Hwang6, Hyunwoong Ko7, Sang-Hyuk Jung1, Injeong Shim1, Soojin Cha1, Hyewon Lee8, Beomsu Kim1, Joohyun Yoon2, Tae Hyon Ha2, Doh Kwan Kim9, Jinho Kim10, Woong-Yang Park11, Aysu Okbay12, Bong-Jo Kim6, Young Jin Kim13, Woojae Myung14, Hong-Hee Won15,16.
Abstract
Subjective well-being (SWB) has been explored in European ancestral populations; however, whether the SWB genetic architecture is shared across populations remains unclear. We conducted a cross-population genome-wide association study for SWB using samples from Korean (n = 110,919) and European (n = 563,176) ancestries. Five ancestry-specific loci and twelve cross-ancestry significant genomic loci were identified. One novel locus (rs12298541 near HMGA2) associated with SWB was also identified through the European meta-analysis. Significant cross-ancestry genetic correlation for SWB between samples was observed. Polygenic risk analysis in an independent Korean cohort (n = 22,455) demonstrated transferability between populations. Significant correlations between SWB and major depressive disorder, and significant enrichment of central nervous system-related polymorphisms heritability in both ancestry populations were found. Hence, large-scale cross-ancestry genome-wide association studies can advance our understanding of SWB genetic architecture and mental health.Entities:
Mesh：
Year: 2022 PMID： 35589828 DOI： 10.1038/s41562-022-01343-5
Source DB: PubMed Journal: Nat Hum Behav ISSN： 2397-3374