Literature DB >> 10400606

Growth phase-dependent regulation of Vsr endonuclease may contribute to 5-methylcytosine mutational hot spots in Escherichia coli.

G Macintyre1, P Pitsikas, C G Cupples.   

Abstract

Using rabbit polyclonal antibodies, we have shown that the Dcm cytosine methylase of Escherichia coli is maintained at a constant level during cell growth, while Vsr endonuclease levels are growth phase dependent. Decreased production of Vsr relative to Dcm during the log phase may contribute substantially to the mutability of 5-methylcytosine.

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Year:  1999        PMID： 10400606      PMCID： PMC93950     

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  13 in total

1.  Overexpression of vsr in Escherichia coli is mutagenic.

Authors:  K M Doiron; S Viau; M Koutroumanis; C G Cupples
Journal:  J Bacteriol       Date:  1996-07       Impact factor: 3.490

2.  A gene required for very short patch repair in Escherichia coli is adjacent to the DNA cytosine methylase gene.

Authors:  A Sohail; M Lieb; M Dar; A S Bhagwat
Journal:  J Bacteriol       Date:  1990-08       Impact factor: 3.490

3.  In vitro correction of G.T mispairs to G.C pairs in nuclear extracts from human cells.

Authors:  K Wiebauer; J Jiricny
Journal:  Nature       Date:  1989-05-18       Impact factor: 49.962

4.  Molecular basis of base substitution hotspots in Escherichia coli.

Authors:  C Coulondre; J H Miller; P J Farabaugh; W Gilbert
Journal:  Nature       Date:  1978-08-24       Impact factor: 49.962

5.  5-Methylcytosine as an endogenous mutagen in the human LDL receptor and p53 genes.

Authors:  W M Rideout; G A Coetzee; A F Olumi; P A Jones
Journal:  Science       Date:  1990-09-14       Impact factor: 47.728

6.  5-Methylcytosine is not a mutation hot spot in nondividing Escherichia coli.

Authors:  M Lieb; S Rehmat
Journal:  Proc Natl Acad Sci U S A       Date:  1997-02-04       Impact factor: 11.205

7.  Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.

Authors:  E Li; T H Bestor; R Jaenisch
Journal:  Cell       Date:  1992-06-12       Impact factor: 41.582

8.  The vsr gene product of E. coli K-12 is a strand- and sequence-specific DNA mismatch endonuclease.

Authors:  F Hennecke; H Kolmar; K Bründl; H J Fritz
Journal:  Nature       Date:  1991-10-24       Impact factor: 49.962

9.  Spontaneous mutation at a 5-methylcytosine hotspot is prevented by very short patch (VSP) mismatch repair.

Authors:  M Lieb
Journal:  Genetics       Date:  1991-05       Impact factor: 4.562

Review 10.  Very short patch repair: reducing the cost of cytosine methylation.

Authors:  M Lieb; A S Bhagwat
Journal:  Mol Microbiol       Date:  1996-05       Impact factor: 3.501
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  9 in total

1.  Very-short-patch repair in Escherichia coli requires the dam adenine methylase.

Authors:  D C Bell; C G Cupples
Journal:  J Bacteriol       Date:  2001-06       Impact factor: 3.490

2.  The Escherichia coli mismatch repair protein MutL recruits the Vsr and MutH endonucleases in response to DNA damage.

Authors:  Yaroslava Y Polosina; Justin Mui; Photini Pitsikas; Claire G Cupples
Journal:  J Bacteriol       Date:  2009-04-17       Impact factor: 3.490

3.  Lowering S-adenosylmethionine levels in Escherichia coli modulates C-to-T transition mutations.

Authors:  G Macintyre; C V Atwood; C G Cupples
Journal:  J Bacteriol       Date:  2001-02       Impact factor: 3.490

4.  Genomics of DNA cytosine methylation in Escherichia coli reveals its role in stationary phase transcription.

Authors:  Christina Kahramanoglou; Ana I Prieto; Supriya Khedkar; Bettina Haase; Ankur Gupta; Vladimir Benes; Gillian M Fraser; Nicholas M Luscombe; Aswin S N Seshasayee
Journal:  Nat Commun       Date:  2012-06-06       Impact factor: 14.919

Review 5.  Roles of DNA adenine methylation in host-pathogen interactions: mismatch repair, transcriptional regulation, and more.

Authors:  Martin G Marinus; Josep Casadesus
Journal:  FEMS Microbiol Rev       Date:  2009-01-19       Impact factor: 16.408

6.  DNA Mismatch Repair.

Authors:  M G Marinus
Journal:  EcoSal Plus       Date:  2012-11

7.  DNA Methylation.

Authors:  M G Marinus; A Løbner-Olesen
Journal:  EcoSal Plus       Date:  2014-05

8.  Physical and functional interactions between Escherichia coli MutL and the Vsr repair endonuclease.

Authors:  Roger J Heinze; Luis Giron-Monzon; Alexandra Solovyova; Sarah L Elliot; Sven Geisler; Claire G Cupples; Bernard A Connolly; Peter Friedhoff
Journal:  Nucleic Acids Res       Date:  2009-05-27       Impact factor: 16.971

9.  Nucleoid-associated proteins affect mutation dynamics in E. coli in a growth phase-specific manner.

Authors:  Tobias Warnecke; Fran Supek; Ben Lehner
Journal:  PLoS Comput Biol       Date:  2012-12-20       Impact factor: 4.475
  9 in total

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