Literature DB >> 35581033

A new Down syndrome rat model races forward.

Randall J Roper1, Charles R Goodlett2.   

Abstract

Animal models of Down syndrome (DS) provide an essential resource for understanding genetic, cellular, and molecular contributions to traits associated with trisomy 21 (Ts21). Recent genetic enhancements in the development of DS models, including the new TcHSA21rat model (Kazuki et al.), have potential to transform our understanding of and potential therapies for Ts21.
Copyright © 2022 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  animal models; gene dosage; gene expression; neurodevelopment; trisomy

Mesh：

Year:  2022        PMID： 35581033      PMCID： PMC9561036          DOI： 10.1016/j.tig.2022.05.001

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.821


  10 in total

Review 1.  Towards the neural population doctrine.

Authors:  Shreya Saxena; John P Cunningham
Journal:  Curr Opin Neurobiol       Date:  2019-03-13       Impact factor: 6.627

2.  The Mighty Mouse: the impact of rodents on advances in biomedical research.

Authors:  Elizabeth C Bryda
Journal:  Mo Med       Date:  2013 May-Jun

3.  A transchromosomic rat model with human chromosome 21 shows robust Down syndrome features.

Authors:  Yasuhiro Kazuki; Feng J Gao; Miho Yamakawa; Masumi Hirabayashi; Kanako Kazuki; Naoyo Kajitani; Sachiko Miyagawa-Tomita; Satoshi Abe; Makoto Sanbo; Hiromasa Hara; Hiroshi Kuniishi; Satoshi Ichisaka; Yoshio Hata; Moeka Koshima; Haruka Takayama; Shoko Takehara; Yuji Nakayama; Masaharu Hiratsuka; Yuichi Iida; Satoko Matsukura; Naohiro Noda; Yicong Li; Anna J Moyer; Bei Cheng; Nandini Singh; Joan T Richtsmeier; Mitsuo Oshimura; Roger H Reeves
Journal:  Am J Hum Genet       Date:  2022-01-24       Impact factor: 11.043

Review 4.  All Creatures Great and Small: New Approaches for Understanding Down Syndrome Genetics.

Authors:  Anna J Moyer; Katheleen Gardiner; Roger H Reeves
Journal:  Trends Genet       Date:  2020-10-20       Impact factor: 11.639

Review 5.  Animal Use in Neurobiological Research.

Authors:  Witold Żakowski
Journal:  Neuroscience       Date:  2020-03-07       Impact factor: 3.590

Review 6.  Mouse models of Down syndrome as a tool to unravel the causes of mental disabilities.

Authors:  Noemí Rueda; Jesús Flórez; Carmen Martínez-Cué
Journal:  Neural Plast       Date:  2012-05-22       Impact factor: 3.599

Review 7.  Rodent models in neuroscience research: is it a rat race?

Authors:  Bart Ellenbroek; Jiun Youn
Journal:  Dis Model Mech       Date:  2016-10-01       Impact factor: 5.758

8.  A non-mosaic transchromosomic mouse model of down syndrome carrying the long arm of human chromosome 21.

Authors:  Yasuhiro Kazuki; Feng J Gao; Yicong Li; Anna J Moyer; Benjamin Devenney; Kei Hiramatsu; Sachiko Miyagawa-Tomita; Satoshi Abe; Kanako Kazuki; Naoyo Kajitani; Narumi Uno; Shoko Takehara; Masato Takiguchi; Miho Yamakawa; Atsushi Hasegawa; Ritsuko Shimizu; Satoko Matsukura; Naohiro Noda; Narumi Ogonuki; Kimiko Inoue; Shogo Matoba; Atsuo Ogura; Liliana D Florea; Alena Savonenko; Meifang Xiao; Dan Wu; Denise As Batista; Junhua Yang; Zhaozhu Qiu; Nandini Singh; Joan T Richtsmeier; Takashi Takeuchi; Mitsuo Oshimura; Roger H Reeves
Journal:  Elife       Date:  2020-06-29       Impact factor: 8.140

9.  Massively parallel sequencing reveals the complex structure of an irradiated human chromosome on a mouse background in the Tc1 model of Down syndrome.

Authors:  Susan M Gribble; Frances K Wiseman; Stephen Clayton; Elena Prigmore; Elizabeth Langley; Fengtang Yang; Sean Maguire; Beiyuan Fu; Diana Rajan; Olivia Sheppard; Carol Scott; Heidi Hauser; Philip J Stephens; Lucy A Stebbings; Bee Ling Ng; Tomas Fitzgerald; Michael A Quail; Ruby Banerjee; Kai Rothkamm; Victor L J Tybulewicz; Elizabeth M C Fisher; Nigel P Carter
Journal:  PLoS One       Date:  2013-04-15       Impact factor: 3.240

Review 10.  Rodent models in Down syndrome research: impact and future opportunities.

Authors:  Yann Herault; Jean M Delabar; Elizabeth M C Fisher; Victor L J Tybulewicz; Eugene Yu; Veronique Brault
Journal:  Dis Model Mech       Date:  2017-10-01       Impact factor: 5.758
  10 in total

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