Hye-Sun Shin1,2, Min-Hee Hong1, Ja-Young Moon3, Seon-Ju Sim1,2. 1. Department of Dental Hygiene, Baekseok University, (31065) 1 Baekseokdehak-Ro, Dongnam-Gu, Cheonan, Chungnam, South Korea. 2. Big Data Statistics Institute, Cheonan, South Korea. 3. Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, (03722) 50-1, Yonsei-Ro, Seodaemun-gu, Seoul, South Korea. mjy0113@daum.net.
Abstract
OBJECTIVE: This study aimed to evaluate the association of periodontal disease with non-alcoholic fatty liver disease (NAFLD). MATERIALS AND METHODS: A retrospective follow-up study using the National Health Insurance Service-National Sample Cohort was performed from 2002 to 2015 in the Korean population. A total of 165,032 subjects were followed up for incident NAFLD during 11 years. Periodontal disease and NAFLD were defined by a diagnosis using the International Statistical Classification of Diseases and Related Health Problems, 10th revision (ICD-10) codes. Periodontal status was used as the severity of periodontal status and the number of dental visit due to PD. RESULTS: Periodontitis was associated with a 4% increase in risk for NAFLD after adjusting for socio-demographic factor, health behaviors, and systemic diseases (adjusted hazard ratio [aHR] = 1.04, 95% CI = 1.01 to 1.07). Between the number of dental visit due to PD and the risk for NAFLD was observed a dose-effect association (aHR = 1.02, 95% CI = 0.99 to 1.05 for once; aHR = 1.10, 95% CI = 1.06 to 1.15 for two times; aHR = 1.14, 95% CI = 1.06 to 1.24 for three times). CONCLUSIONS: Our data confirmed that periodontitis showed an association with a higher incidence of NAFLD. CLINICAL RELEVANCE: Prevention and management of periodontal disease could be beneficial for reducing the risk of NAFLD.
OBJECTIVE: This study aimed to evaluate the association of periodontal disease with non-alcoholic fatty liver disease (NAFLD). MATERIALS AND METHODS: A retrospective follow-up study using the National Health Insurance Service-National Sample Cohort was performed from 2002 to 2015 in the Korean population. A total of 165,032 subjects were followed up for incident NAFLD during 11 years. Periodontal disease and NAFLD were defined by a diagnosis using the International Statistical Classification of Diseases and Related Health Problems, 10th revision (ICD-10) codes. Periodontal status was used as the severity of periodontal status and the number of dental visit due to PD. RESULTS: Periodontitis was associated with a 4% increase in risk for NAFLD after adjusting for socio-demographic factor, health behaviors, and systemic diseases (adjusted hazard ratio [aHR] = 1.04, 95% CI = 1.01 to 1.07). Between the number of dental visit due to PD and the risk for NAFLD was observed a dose-effect association (aHR = 1.02, 95% CI = 0.99 to 1.05 for once; aHR = 1.10, 95% CI = 1.06 to 1.15 for two times; aHR = 1.14, 95% CI = 1.06 to 1.24 for three times). CONCLUSIONS: Our data confirmed that periodontitis showed an association with a higher incidence of NAFLD. CLINICAL RELEVANCE: Prevention and management of periodontal disease could be beneficial for reducing the risk of NAFLD.
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