Rodrigo Martin-Cabezas1, Narendra Seelam1, Catherine Petit1, Kévimy Agossa2, Sébastien Gaertner3, Henri Tenenbaum4, Jean-Luc Davideau4, Olivier Huck5. 1. Université de Strasbourg, Faculté de Chirurgie Dentaire, Department of Periodontology, Strasbourg, France. 2. University of Lille, Dental Faculty, Department of Periodontology. 3. Service Hypertension, maladies vasculaires et pharmacologie clinique, Hôpitaux Universitaires de Strasbourg, Strasbourg, France. 4. Université de Strasbourg, Faculté de Chirurgie Dentaire, Department of Periodontology, Strasbourg, France; INSERM 1109 «Osteoarticular & Dental Regenerative Nanomedicine», Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, France. 5. Université de Strasbourg, Faculté de Chirurgie Dentaire, Department of Periodontology, Strasbourg, France; INSERM 1109 «Osteoarticular & Dental Regenerative Nanomedicine», Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, France. Electronic address: huck.olivier@gmail.com.
Abstract
BACKGROUND: Several studies have shown that periodontal diseases are associated with hypertension (HT). However, heterogeneity among populations, diagnosis criteria, and shared risk factors represent some difficulties in terms of interpretation. Therefore, the aim of this study was to determine the magnitude of the association between periodontal diseases and HT. METHODS AND RESULTS: A systematic review and meta-analysis, including studies published up to June 2016, have been performed. Sixteen studies assessing the association between periodontal diseases and HT have been included. The meta-analysis considering all included studies (moderate to severe periodontitis) showed that the presence of HT was associated with the presence of periodontal diseases (OR, 1.50; 95% CI, 1.27-1.78). To reduce potential bias, a stratified analysis has been performed illustrating the impact of inclusion criteria and adjustments on the magnitude of the association. Interestingly, when only studies with secure diagnosis of severe periodontitis and HT were considered, an OR=1.64 (95% CI, 1.23-2.19) has been measured. CONCLUSIONS: Periodontal diseases are associated with a higher risk of HT especially for severe periodontitis. However, no conclusions could be made regarding the causative involvement of periodontal diseases mainly due to the reduced number of available prospective studies and remaining questions regarding underlying biological mechanisms.
BACKGROUND: Several studies have shown that periodontal diseases are associated with hypertension (HT). However, heterogeneity among populations, diagnosis criteria, and shared risk factors represent some difficulties in terms of interpretation. Therefore, the aim of this study was to determine the magnitude of the association between periodontal diseases and HT. METHODS AND RESULTS: A systematic review and meta-analysis, including studies published up to June 2016, have been performed. Sixteen studies assessing the association between periodontal diseases and HT have been included. The meta-analysis considering all included studies (moderate to severe periodontitis) showed that the presence of HT was associated with the presence of periodontal diseases (OR, 1.50; 95% CI, 1.27-1.78). To reduce potential bias, a stratified analysis has been performed illustrating the impact of inclusion criteria and adjustments on the magnitude of the association. Interestingly, when only studies with secure diagnosis of severe periodontitis and HT were considered, an OR=1.64 (95% CI, 1.23-2.19) has been measured. CONCLUSIONS: Periodontal diseases are associated with a higher risk of HT especially for severe periodontitis. However, no conclusions could be made regarding the causative involvement of periodontal diseases mainly due to the reduced number of available prospective studies and remaining questions regarding underlying biological mechanisms.
Authors: Curt D Sigmund; Robert M Carey; Lawrence J Appel; Donna K Arnett; Hayden B Bosworth; William C Cushman; Zorina S Galis; Melissa Green Parker; John E Hall; David G Harrison; Alicia A McDonough; Holly L Nicastro; Suzanne Oparil; John W Osborn; Mohan K Raizada; Jacqueline D Wright; Young S Oh Journal: Hypertension Date: 2020-02-17 Impact factor: 10.190
Authors: Stanisław Surma; Monika Romańczyk; Justyna Witalińska-Łabuzek; Maciej R Czerniuk; Krzysztof Łabuzek; Krzysztof J Filipiak Journal: Curr Hypertens Rep Date: 2021-05-07 Impact factor: 5.369