| Literature DB >> 35551656 |
Vishal Navani1, Moira C Graves2, Hiren Mandaliya3, Martin Hong3, Andre van der Westhuizen2,3, Jennifer Martin2,4, Nikola A Bowden2.
Abstract
Melanoma gave science a window into the role immune evasion plays in the development of malignancy. The entire spectrum of immune focused anti-cancer therapies has been subjected to clinical trials in this disease, with limited success until the immune checkpoint blockade era. That revolution launched first in melanoma, heralded a landscape change throughout cancer that continues to reverberate today.Entities:
Keywords: CTLA-4; Immune checkpoint; Immunotherapy; Immunotherapy resistance; Immunotherapy response; Melanoma; PD-1; PD-L1
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Substances:
Year: 2022 PMID: 35551656 DOI: 10.1007/978-3-030-96376-7_2
Source DB: PubMed Journal: Cancer Treat Res ISSN: 0927-3042