| Literature DB >> 35551307 |
Cassandra N Spracklen1,2, Weihua Zhang3,4, Maggie C Y Ng5,6,7, Lauren E Petty5, Hidetoshi Kitajima8,9,10,11, Grace Z Yu12,8, Sina Rüeger13, Leo Speidel14,15, Anubha Mahajan16,17,18, Young Jin Kim19, Momoko Horikoshi20, Josep M Mercader21,22,23, Daniel Taliun24, Sanghoon Moon8,19, Soo-Heon Kwak8,25, Neil R Robertson12,8, Nigel W Rayner12,8,26,27, Marie Loh3,28,29, Bong-Jo Kim19, Joshua Chiou30,31, Irene Miguel-Escalada32,33, Pietro Della Briotta Parolo13, Kuang Lin34, Fiona Bragg34,35, Michael H Preuss36, Fumihiko Takeuchi37, Jana Nano38, Xiuqing Guo39, Amel Lamri40,41, Masahiro Nakatochi42, Robert A Scott43, Jung-Jin Lee44, Alicia Huerta-Chagoya45,46, Mariaelisa Graff47, Jin-Fang Chai48, Esteban J Parra49, Jie Yao39, Lawrence F Bielak50, Yasuharu Tabara51, Yang Hai39, Valgerdur Steinthorsdottir52, James P Cook53, Mart Kals54, Niels Grarup55, Ellen M Schmidt24, Ian Pan56, Tamar Sofer57,58,59, Matthias Wuttke60, Chloe Sarnowski61,62, Christian Gieger63,64,65, Darryl Nousome66, Stella Trompet67,68, Jirong Long69, Meng Sun8, Lin Tong70, Wei-Min Chen71, Meraj Ahmad72, Raymond Noordam68, Victor J Y Lim48, Claudia H T Tam73,74, Yoonjung Yoonie Joo75,76,77, Chien-Hsiun Chen78, Laura M Raffield1, Cécile Lecoeur79,80, Bram Peter Prins26, Aude Nicolas81, Lisa R Yanek82, Guanjie Chen83, Richard A Jensen84, Salman Tajuddin85, Edmond K Kabagambe69,86, Ping An87, Anny H Xiang88, Hyeok Sun Choi89, Brian E Cade23,58, Jingyi Tan39, Jack Flanagan20,53, Fernando Abaitua8,90, Linda S Adair91, Adebowale Adeyemo8,83, Carlos A Aguilar-Salinas92, Masato Akiyama93,94, Sonia S Anand40,41,95, Alain Bertoni96, Zheng Bian97, Jette Bork-Jensen55, Ivan Brandslund98,99, Jennifer A Brody84, Chad M Brummett100, Thomas A Buchanan101, Mickaël Canouil79,80, Juliana C N Chan73,74,102,103, Li-Ching Chang78, Miao-Li Chee104, Ji Chen105,106, Shyh-Huei Chen107, Yuan-Tsong Chen78, Zhengming Chen34,35, Lee-Ming Chuang108,109, Mary Cushman110, Swapan K Das111, H Janaka de Silva112, George Dedoussis113, Latchezar Dimitrov6, Ayo P Doumatey83, Shufa Du91,114, Qing Duan1, Kai-Uwe Eckardt115,116, Leslie S Emery117, Daniel S Evans118, Michele K Evans85, Krista Fischer54, James S Floyd84, Ian Ford119, Myriam Fornage120, Oscar H Franco38, Timothy M Frayling121, Barry I Freedman122, Christian Fuchsberger24,123, Pauline Genter124, Hertzel C Gerstein40,41,95, Vilmantas Giedraitis125, Clicerio González-Villalpando126, Maria Elena González-Villalpando126, Mark O Goodarzi127, Penny Gordon-Larsen91,114, David Gorkin128, Myron Gross129, Yu Guo97, Sophie Hackinger26, Sohee Han19, Andrew T Hattersley130, Christian Herder63,131,132, Annie-Green Howard114,133, Willa Hsueh134, Mengna Huang56,135, Wei Huang136, Yi-Jen Hung137,138, Mi Yeong Hwang19, Chii-Min Hwu139,140, Sahoko Ichihara141, Mohammad Arfan Ikram38, Martin Ingelsson125, Md Tariqul Islam142, Masato Isono37, Hye-Mi Jang19, Farzana Jasmine70, Guozhi Jiang73,74, Jost B Jonas143, Marit E Jørgensen144,145, Torben Jørgensen146,147,148, Yoichiro Kamatani93,149, Fouad R Kandeel150, Anuradhani Kasturiratne151, Tomohiro Katsuya152,153, Varinderpal Kaur22, Takahisa Kawaguchi51, Jacob M Keaton6,69,154, Abel N Kho155,156, Chiea-Chuen Khor157, Muhammad G Kibriya70, Duk-Hwan Kim158, Katsuhiko Kohara159,160, Jennifer Kriebel63,64,65, Florian Kronenberg161, Johanna Kuusisto162, Kristi Läll54,163, Leslie A Lange164, Myung-Shik Lee165,166, Nanette R Lee167, Aaron Leong22,168,169, Liming Li170, Yun Li1, Ruifang Li-Gao171, Symen Ligthart38, Cecilia M Lindgren8,172,173, Allan Linneberg146,174, Ching-Ti Liu61, Jianjun Liu157,175, Adam E Locke176,177,178, Tin Louie117, Jian'an Luan43, Andrea O Luk73,74, Xi Luo179, Jun Lv170, Valeriya Lyssenko180,181, Vasiliki Mamakou182, K Radha Mani72, Thomas Meitinger183,184,185, Andres Metspalu54, Andrew D Morris186, Girish N Nadkarni36,187,188, Jerry L Nadler189, Michael A Nalls81,190,191, Uma Nayak71, Suraj S Nongmaithem72, Ioanna Ntalla192, Yukinori Okada193,194,195, Lorena Orozco196, Sanjay R Patel197, Mark A Pereira198, Annette Peters63,64,185, Fraser J Pirie199, Bianca Porneala169, Gauri Prasad200,201, Sebastian Preissl128, Laura J Rasmussen-Torvik202, Alexander P Reiner203, Michael Roden63,131,132, Rebecca Rohde47, Kathryn Roll39, Charumathi Sabanayagam104,204,205, Maike Sander206,207,208, Kevin Sandow39, Naveed Sattar209, Sebastian Schönherr161, Claudia Schurmann36,187,210, Mohammad Shahriar70,211, Jinxiu Shi136, Dong Mun Shin19, Daniel Shriner83, Jennifer A Smith50,212, Wing Yee So8,73,102, Alena Stančáková162, Adrienne M Stilp117, Konstantin Strauch8,213,214,215, Ken Suzuki20,93,193,216, Atsushi Takahashi93,217, Kent D Taylor39, Barbara Thorand63,64, Gudmar Thorleifsson52, Unnur Thorsteinsdottir52,218, Brian Tomlinson73,219, Jason M Torres8,220, Fuu-Jen Tsai221, Jaakko Tuomilehto222,223,224,225, Teresa Tusie-Luna226,227, Miriam S Udler21,22,168, Adan Valladares-Salgado228, Rob M van Dam48,175, Jan B van Klinken229,230,231, Rohit Varma232, Marijana Vujkovic233, Niels Wacher-Rodarte234, Eleanor Wheeler43, Eric A Whitsel47,235, Ananda R Wickremasinghe151, Ko Willems van Dijk229,230,236, Daniel R Witte237,238, Chittaranjan S Yajnik239, Ken Yamamoto240, Toshimasa Yamauchi216, Loïc Yengo241, Kyungheon Yoon19, Canqing Yu170, Jian-Min Yuan242,243, Salim Yusuf40,41,95, Liang Zhang104, Wei Zheng69, Leslie J Raffel244, Michiya Igase245, Eli Ipp124, Susan Redline23,58,246, Yoon Shin Cho89, Lars Lind247, Michael A Province87, Craig L Hanis248, Patricia A Peyser50, Erik Ingelsson249,250, Alan B Zonderman85, Bruce M Psaty84,251,252, Ya-Xing Wang253, Charles N Rotimi83, Diane M Becker82, Fumihiko Matsuda51, Yongmei Liu96,254, Eleftheria Zeggini26,27,255, Mitsuhiro Yokota256, Stephen S Rich257, Charles Kooperberg203, James S Pankow198, James C Engert258,259, Yii-Der Ida Chen39, Philippe Froguel79,80,260, James G Wilson261, Wayne H H Sheu138,140,262, Sharon L R Kardia50, Jer-Yuarn Wu78, M Geoffrey Hayes75,263,264, Ronald C W Ma73,74,102,103, Tien-Yin Wong104,204,205, Leif Groop13,180, Dennis O Mook-Kanamori171, Giriraj R Chandak72, Francis S Collins154, Dwaipayan Bharadwaj200,265, Guillaume Paré41,266, Michèle M Sale71, Habibul Ahsan70, Ayesha A Motala199, Xiao-Ou Shu69, Kyong-Soo Park25,267,268, J Wouter Jukema67,269, Miguel Cruz228, Roberta McKean-Cowdin66, Harald Grallert63,64,65, Ching-Yu Cheng104,204,205, Erwin P Bottinger36,187,210, Abbas Dehghan3,38,270, E-Shyong Tai48,175,271, Josée Dupuis61, Norihiro Kato37, Markku Laakso162, Anna Köttgen60, Woon-Puay Koh272,273, Colin N A Palmer274, Simin Liu56,135,275, Goncalo Abecasis24, Jaspal S Kooner4,270,276,277, Ruth J F Loos36,55,278, Kari E North47, Christopher A Haiman66, Jose C Florez21,22,168, Danish Saleheen44,279,280, Torben Hansen55, Oluf Pedersen55, Reedik Mägi54, Claudia Langenberg43,281, Nicholas J Wareham43, Shiro Maeda20,282,283, Takashi Kadowaki216,284, Juyoung Lee19, Iona Y Millwood34,35, Robin G Walters34,35, Kari Stefansson52,218, Simon R Myers8,285, Jorge Ferrer32,33,286, Kyle J Gaulton206,207, James B Meigs21,168,169, Karen L Mohlke1, Anna L Gloyn12,8,287,288, Donald W Bowden6,7,289, Jennifer E Below5, John C Chambers3,4,28,270,276, Xueling Sim48, Michael Boehnke24, Jerome I Rotter39, Mark I McCarthy290,291,292,293, Andrew P Morris294,295,296,297,298.
Abstract
We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non-European descent) through the Diabetes Meta-Analysis of Trans-Ethnic association studies (DIAMANTE) Consortium. Multi-ancestry GWAS meta-analysis identified 237 loci attaining stringent genome-wide significance (P < 5 × 10-9), which were delineated to 338 distinct association signals. Fine-mapping of these signals was enhanced by the increased sample size and expanded population diversity of the multi-ancestry meta-analysis, which localized 54.4% of T2D associations to a single variant with >50% posterior probability. This improved fine-mapping enabled systematic assessment of candidate causal genes and molecular mechanisms through which T2D associations are mediated, laying the foundations for functional investigations. Multi-ancestry genetic risk scores enhanced transferability of T2D prediction across diverse populations. Our study provides a step toward more effective clinical translation of T2D GWAS to improve global health for all, irrespective of genetic background.Entities:
Mesh：
Year: 2022 PMID： 35551307 PMCID： PMC9179018 DOI： 10.1038/s41588-022-01058-3
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 41.307