| Literature DB >> 35546611 |
Kirthi Menon1, Barbora de Courten2, Zanfina Ademi1,3, Alice J Owen1, Danny Liew1,4, Ella Zomer5.
Abstract
BACKGROUND/Entities:
Mesh:
Year: 2022 PMID: 35546611 PMCID: PMC9092329 DOI: 10.1038/s41366-022-01133-z
Source DB: PubMed Journal: Int J Obes (Lond) ISSN: 0307-0565 Impact factor: 5.551
Key data inputs, their base-case values and the values used in scenario analyses.
| Parameters | Cohort/population | Base-case values | Confidence intervals | |
|---|---|---|---|---|
| Lower bound | Upper bound | |||
| Productivity indicesa | With obesity | 0.977 | 0.972 | 0.981 |
| With overweight | 0.981 | 0.979 | 0.984 | |
| With normal weight | 0.982 | 0.980 | 0.985 | |
| Hazard ratio for mortality with obesityb | With obesity | 1.44 | 1.34 | 1.54 |
| Annual discount rate | Total | 5% | 3% | – |
aProductivity indices were derived from absenteeism data reported by Andreyeva et al. where fewer days off work means greater productivity and therefore a higher productivity index and vice versa.
bThe hazard ratio of mortality for the population with obesity was compared to the population with normal weight (reference population). As the hazard ratio for the population with overweight was non-significant, we assumed that the risk of mortality was equal to the population with normal weight.
Total years of life lived, PALYs and value of PALYs estimated for the Australian working-age population from 2021 to 2030 (values for the total population).
| Year | Years of life lived | PALYs | Value of PALYsa |
|---|---|---|---|
| 2021 | 15,583,957 | 9,636,915 | $1,923,157,871,084 |
| 2022 | 15,011,855 | 9,277,567 | $1,872,809,452,263 |
| 2023 | 14,453,452 | 8,927,275 | $1,822,655,254,952 |
| 2024 | 13,913,026 | 8,589,112 | $1,773,391,823,052 |
| 2025 | 13,389,766 | 8,263,956 | $1,725,286,509,097 |
| 2026 | 12,882,629 | 7,949,860 | $1,678,018,356,545 |
| 2027 | 12,394,126 | 7,646,484 | $1,631,590,915,741 |
| 2028 | 11,922,672 | 7,354,505 | $1,586,224,489,216 |
| 2029 | 11,465,604 | 7,073,263 | $1,541,853,884,983 |
| 2030 | 11,023,166 | 6,803,637 | $1,498,746,714,447 |
| Total | 132,040,252 | 81,522,574 | $17,053,735,271,380 |
All outcomes reported were subject to an annual discount rate of 5%; costs are reported in Australian dollars (AU$); due to rounding of data presented in this table, totals may not precisely match.
PALYs productivity-adjusted life years.
aThe value of PALYs were estimated using gross domestic product (GDP) per equivalent full-time worker (EFT).
Scenario analyses to assess the impact of reducing the incidence of obesity on total years of life lived, PALYs and value of PALYs for the Australian working-age population from 2021 to 2030 (values for the total population).
| Obesity incidence | Years of life lived | Years of life saved | PALYs | PALYs saved | Value of PALYsa | Value of PALYs saved |
|---|---|---|---|---|---|---|
| 100% (base case) | 132,040,252 | 81,522,574 | $17,053,735,271,380 | – | ||
| 98% | 132,040,517 | 265 | 81,523,064 | 491 | $17,053,839,957,357 | $104,685,977 |
| 95% | 132,040,915 | 663 | 81,523,802 | 1229 | $17,053,997,456,963 | $262,185,583 |
All outcomes were subject to an annual discount rate of 5%; costs are reported in Australian dollars (AU$); due to rounding of data presented in this table, values may not precisely match.
PALYs productivity-adjusted life years.
aThe value of PALYs were estimated using gross domestic product (GDP) per equivalent full-time worker (EFT).
One-way sensitivity and scenario analyses to assess the impact of the uncertainties surrounding key input parameters on years of life lived, PALYs and the value of PALYs for the Australian working-age population from 2021 to 2030 (values for the total population).
| Years of life lived | Years of life gained/lost | PALYs lived | PALYs gained/lost | Value of PALYsa | Value of PALYs gained/lost | ||
|---|---|---|---|---|---|---|---|
| Base caseb | 132,040,252 | 81,522,574 | $17,053,735,271,380 | ||||
| One-way sensitivity analysis | |||||||
| Productivity indicesc | |||||||
| 1a | Lower bound | 132,040,252 | N/A | 81,275,885 | −246,688 | $17,002,147,350,544 | −$51,587,920,835 |
| 1b | Upper bound | 132,040,252 | N/A | 81,769,478 | +246,904 | $17,105,368,304,068 | +$51,633,032,689 |
| Hazard ratio for mortality with obesity | |||||||
| 2a | Lower bound | 132,075,264 | +35,012 | 81,539,936 | +17,362 | $17,057,424,035,182 | +$3,688,763,802 |
| 2b | Upper bound | 132,005,303 | −34,949 | 81,505,236 | −17,337 | $17,050,051,866,285 | −$3,683,405,094 |
| Scenario analysis | |||||||
| 3 | No temporal growth in GDP | 132,040,252 | N/A | 81,522,574 | N/a | $16,268,772,448,145 | −$784,962,823,234 |
| 4 | Annual discount rate of 3% | 146,102,529 | +14,062,277 | 90,201,276 | +8,678,703 | $18,902,035,239,631 | +$1,848,299,968,251 |
| 5 | Recovery of obesity omittedd | 132,021,912 | −18,340 | 81,493,289 | −29,285 | $17,047,484,354,010 | −$6,250,917,369 |
All outcomes were subject to an annual discount rate of 5%; all costs are reported in Australian dollars (AU$); due to rounding of data presented in this table, values may not precisely match.
+ Gained, − lost, N/A not applicable, PALYs productivity-adjusted life years.
aThe value of PALYs were estimated using gross domestic product (GDP) per equivalent full-time worker (EFT).
bThe base case represents the results for the total population assuming the current trajectory of obesity over the 10-year period of 2021 to 2030.
cUpper and lower bounds of the productivity indices were estimated using the lower and upper bounds of the 95% confidence intervals for absenteeism data reported by Andreyeva et al. where fewer days off work means greater productivity and the inverse for more days off work.
dPeople with obesity could not ‘recover’, and therefore there was no movement from the obese weight category to overweight or normal weight categories.