Intrathecal Drug Delivery Systems Survey: Trends in Utilization in Pain Practice.

Background: The use of intrathecal drug delivery for chronic and cancer pain medicine has been established for decades. However, optimization and utilization of this technique still lag behind other modalities for pain control. Some of this may be due to variability of surgical technique, medication usage and education. It is currently unclear on whether or not practitioners follow available algorithms for the use of intrathecal drug delivery systems.
Methods: A survey developed by the American Society of Pain and Neuroscience (ASPN) was sent to its members via email using the cloud-based SurveyMonkey. After 30 days of being available, 159 different providers responded to the survey that consisted of 31 various multiple choice and free response questions. Each question was not required and the number of responses to each varied from 128 to 159.
Results: Approximately 9% of those who successfully received and opened the email containing the survey responded, likely due to a small number of providers working with intrathecal drug delivery systems. Eighty-six of respondents practice medicine in the United States, and 87% of the respondents were attending physicians. A majority of respondents, approximately 74%, were board certified in pain medicine with 69% of respondents being train in anesthesiology. The first and second most used medications for intrathecal pump trial were morphine and fentanyl, respectively. Most respondents, approximately 96%, provide pre-operative/intra-operative antibiotics. The most common first-choice medication for implanted intrathecal pumps was also morphine with the most common implanted location being the abdomen.
Conclusion: Interestingly, there is currently fairly substantial variation in the way providers utilize intrathecal pump delivery for both chronic and cancer pain. There is variation from the training background of the providers providing care, to the pre-implantation trial medications, to where the pump is implanted for each patient, to if the patient has the option to give themselves boluses once implanted. Further research is needed to elucidate current and best practices for intrathecal drug delivery system trials, implantations, and utilization.

Introduction

Intrathecal Drug Delivery has been widely utilized to treat a myriad of chronic conditions including malignant pain, low back pain, neck pain, neuropathic pain, as well as spasticity. These conditions affect a large portion of society, constituting an economic societal burden. Intrathecal drug delivery systems offer a relatively safe, cost-effective, and effective mechanism of drug delivery into the CSF, thereby allowing for more efficacious improvement in pain and spasticity while also minimizing potential adverse effects when compared to other drug administration routes.1,2 With the emergence of intrathecal pump therapies in the 1980s, early treatments were done with fixed continuous intrathecal infusion rates.3 Over the last 40 years, proceduralists have adopted technical variations, divergence, and, at times, questionable intrathecal choices for medications when performing intrathecal pump trials and permanent pump therapy.

Due to this variability, the Polyanalgesic Consensus Conference (PACC) panel was created with the purpose of publishing evidence-based best practice guidelines relating to the safety and efficacy of intrathecal pump therapy.4 This panel has since reconvened multiple times to discuss updates and improvements regarding patient safety and analgesia.5,6 Through this article, the American Society of Pain and Neuroscience (ASPN) aims to demonstrate the differences in practice and discuss their relation to PACC guidelines regarding optimal patient safety and efficacy with regards to intrathecal pump therapy. A survey-based approach was used to gather information that will improve the scope of practice and implementation of intrathecal drug delivery for chronic pain and spasticity patients.

Methods

A survey developed by ASPN was attempted to be sent to 4503 members of the American Society of Pain and Neuroscience (ASPN). The survey was sent via email on April 28th, 2021 using a cloud-based tool called SurveyMonkey to each member of the ASPN with an email on file. The estimated number of members who successfully received and opened the email was 1801. This may have been limited due to inaccurate/unused/unupdated emails for ASPN members along with only a portion of ASPN members working with intrathecal pump delivery systems. The survey was designed to identify respondent’s demographics and background, information about their practices with intrathecal pump trials, pump implantation, and post-implantation information. The survey consisted of 31 different multiple-choice and free response questions. The questionnaire was approved via waiver (does not involve human subjects and patient history information) by the University of Wisconsin Health Sciences IRB.

Each recipient of the survey was only allowed to respond a single time and they were unable to edit their responses once they submitted the survey. Any member of the ASPN who answered a question in the survey was then identified as a respondent. Some respondents who did not answer a specific question in the survey was marked as “skipped” for that question. Once distributed, 30 days were allotted for ASPN members to respond to the survey before the survey was closed and the data was analyzed. Also of note, any respondents who did not submit the survey after starting it were excluded from data analysis.

A total of 159 providers responded to the survey. Participants were not required to answer every question, so there were a variable number of responses to each question ranging from N = 128 to N=159. Data from the survey was extracted from SurveyMonkey and further translated into excel for consolidation of each questions result. The questions were further broken into 4 categories for presentation in the presentation of the results. No statistical analysis was performed due to the nature of this report addressing differences in practice rather than statistical discrepancies.

Results

Response rate of ASPN members who successfully received and opened the email with the link to the survey was estimated to be approximately 9%. However, given that a much smaller percent of ASPN members perform intrathecal pump trials and/or implants, we estimate the response rate of those directly working with intrathecal pump delivery systems to be much higher. Of these 159 respondents, 131 identified as being male, 27 as female, and 1 preferred not to say. There was a variety of provider types including attending physicians, physicians in training, nurse practitioners, and physician assistants, however, the most of respondents were attending physicians (about 87%). Of the physicians, just under 85% were board certified, 72.5% of them completed an ACGME accredited Pain Management Fellowship, and their primary board specialties included anesthesiology, physical medicine and rehabilitation, neurology, neurosurgery, and others including family medicine, neuromusculoskeletal medicine, radiology, orthopedics, and palliative medicine. More than three quarters (76.6%) of respondents attributed pain management to be dedicated to over 80% of their practice. The majority of providers, approximately 70%, fell between the ages of 31 and 50, with all but one of the remaining being 51 years old or older (Table 1). There was a wide range of years each provider has been in practice ranging from being in training now to over 25 years, (Table 1). Twenty-two of the respondents practiced medicine outside of the United States, each of the countries represented is further described in Table 1.

Table 1

Provider Demographics and Practice Background

Question Asked
“What is your gender?”	Male	Female	Prefer not to say
N = 159	131	27	1
“What is your age”	Under 30	31–40	41–50	51–60	61–70	71–80	81+
N = 159	1	55	56	24	18	5	0
“Which country do you practice medicine in?”	United States	Canada	Mexico	Saudi Arabia	Spain	Azerbaijan, Brazil, Costa Rica, Cyprus, India, Iraq	Pakistan, Puerto Rico, South Africa, United Arab Emirates
N = 159	134	6	2	2	5	1 each	1 each
“Which best describes your provider type:”	Attending Physician	Physician in training	Nurse practitioner	Physician assistant
N = 158	137	4	10	7
“If you are a physician, are you Board Certified in Pain Medicine?”	Yes	No	N/A
N = 159	117	21	21
“If you are a physician, did you complete an ACGME accredited Pain Management Fellowship?”	Yes	No	N/A
N = 159	100	38	21
“If you are a Physician, what is your primary board specialty?”	Anesthesiology	Physical Medicine & Rehabilitation	Neurology	Neurosurgery
N = 154	106	23	5	6
“What percentage of your clinical practice is dedicated to Pain Management?	0–20%	21–40%	41–60%	61–80%	81–100%
” N = 158	3	5	10	19	121
“How many years have you been in practice?”	In training	0–5 years	6–10 years	11–15 years	16–20 years	21–25 years	25+ years
N = 158	4	35	38	21	27	11	22

When specifically asked about intrathecal pump therapy, including trials, implants, interrogation, and/or refills, a total of 135 of the 159 respondents said they performed one or more of these. One hundred sixteen, or 73%, respondents perform intrathecal pump trials. However, when asked how trials of intrathecal pumps were performed, there were 138 responses with 78.3% utilizing the single shot approach and the following 21.7% utilizing techniques described in Table 2. Almost three-quarters (73.9%) of respondents never find respiratory depression after a trial for an intrathecal pump, 21% responded between 1% and 10% of the time, and the remaining respondents selected answers over 11% of the time which is further broken down in Table 2. When asked about weaning opioids prior to an intrathecal pump trial, 55.6% of respondents answered that they do wean prior to the trial and 44.4% answered that they do not wean opioids prior to the trial – for those that do wean down, there was a range of answers including a wean to 10–20%, 30%, 50%, 80%, for 48 hours, for one week without opioids, over the course of 2 months, to always below 50MEQ (milliequivalents) for non-cancer and not for cancer, with some weaning completely off. Furthermore, there were 135 responses answering what type of medications and dose that respondents typically used during the trial, answers included: morphine (MS/MSO4) ranging from 0.05mg–0.5mg, fentanyl ranging from 15mcg–100mcg, hydromorphone ranging from 50mcg–0.4mg, prialt ranging from 2mcg–5mcg, “opioids”, baclofen at 50mcg, dilaudid dosing at “100 mcg–5000mcg/day” and “0.3 mg in 2 mL volume”, ziconotide ranging from 2–8mcg and sometimes in addition to fentanyl, and a few respondents not using meds for trials. More than three-quarters (80.3%) of the providers who answer the question on giving antibiotics during an intrathecal pump trial answered that they did not give them, in addition to this 89.8% of responding providers do not prescribe oral antibiotics after the intrathecal pump trial.

Table 2

Intrathecal Pump Trial

Question Asked
“Do you perform any management (i.e.,i trial, implant, interrogation and or refill) for intrathecal pump therapy?”	Yes	No
N = 159	135	24
“Do you perform intrathecal pump trials?”	Yes	No
N = 159	116	43
“How do you perform your trials for intrathecal pumps?”	Single Shot	Continuous epidural catheter with admission to the hospital	Continuous intrathecal catheter and admit to the hospital	Epidural catheter with boluses and send the patient home	Intrathecal catheter with boluses and send the patient home
N = 138	108	8	13	3	6
“How frequently do you find respiratory depression after trial for intrathecal pump?”	Never	1–10%	11–20%	21–30%	31–40%	41–50%	51–100%
N = 138	102	29	4	1	1	1	0
“Do you wean down opioids before a trial for intrathecal pump?”	Yes	No
N = 135	75	65
“What medication do you typically use during the trial for intrathecal pump and what dose?”		Morphine	Bupivacaine	Fentanyl	Hydromorphone		Prialt
		78	6	27	12		8
Free response	“Opioids”	Baclofen	Dilaudid	Ziconotide
N = 135	2	7	7	3
“Do you give antibiotics during trial for intrathecal pump?”	Yes	No
N = 137	27	110
“Do you prescribe oral antibiotics after trial for intrathecal pump?”	Yes	No
N = 137	14	123

The most common main indication for an intrathecal reported from respondents was non-cancer, chronic pain at 66.9% followed by cancer pain at 21.6%, spasticity at 7.9% and others including equal indication with pain and spasticity, both cancer and non-cancer pain, and neuropathic pain at 3.6%. More than half (66.9%) of the providers who responded to the questions asking if they implant intrathecal pumps answered yes and independently to neurosurgery, and 7.4% answered yes and in conjunction with neurosurgery. Morphine was the first-choice medication in an intrathecal pain pump for 63.3% of respondents with others using drugs described in Table 3 and mixtures of each of those drugs; as of note, one participant mentioned they used Buprenorphine since morphine was not readily available in their country. Most respondents (77.4%) surgically implant the pump in the abdomen, with a lower percentage implanting in the low back, buttock, and other locations. The most commonly used sized intrathecal pump across the respondents was 20mL mostly at 56.6% with 40mL at 27.9% and using both equally at 15.4%. Medtronic was selected by 74.5% of respondents when asked which pump brand they typically used, Flowonix was selected by 6.6% of respondents, and both Medtronic and Flowonix was selected by 16.8% of respondents. The majpority (96.3%) of the respondents selected that they give intraoperative/preoperative antibiotics during the implantation of intrathecal pumps.

Table 3

Intrathecal Pump Implantation

Question Asked
“Do you implant intrathecal pumps?”	Yes – independently	Yes – in conjunction with neurosurgery	No
N = 148	99	11	38
“What is the main indication for intrathecal pump implant in your practice?”	Spasticity	Cancer Pain	Non-cancer chronic pain	Other
N = 139	11	30	93	5
“What is your first-choice medication in an intrathecal pump?”	Morphine	Fentanyl	Prialt	Baclofen	Bupivacaine	Buprenorphine	Mix
N = 139	88	5	6	2	2	1	9
	Normal Saline	Dilaudid
	4	22
“Where do you surgically implant the intrathecal pump?”	Abdomen	Low back	Buttock	Other
N = 133	103	17	8	5
“Where do you place your catheter tip?”	Cervical	Thoracic 1–6	Thoracic 7–12	Lumbar	Sacral
N = 128	71	86	114	68	43
“What size of intrathecal pump(s) do you use?”	20 mL mostly	40 mL mostly	Equal
N = 136	77	38	21
“What intrathecal pump brand do you typically use?”	Medtronic	Flowonix	Medtronic and Flowonix	Other
N = 137	102	9	23	3
“Do you give intraoperative/preoperative antibiotics during intrathecal pump implantation?”	Yes	No
N = 134	129	5

As shown in Table 4, 30.2% of respondents answered that they admit patients overnight after an intrathecal pump implant while 53.7% said they did not and only 16.2% answered that they only admit patients overnight if there is a comorbidity. The number of respondents who never saw respiratory depression as a side effect of intrathecal medication after implantation was 70.4%, 26.7% said they see it 1–10% of the time, two respondents said they see it 11–20% of the time, one said 21–30% of the time and one said 31–40% of the time. When asked a about what complications respondents commonly encounter after intrathecal pump implantation, 33.6% selected skin infection, 3% selected meningitis, 26.1% selected medication related complications, 29.9% selected urinary retention, 42.5% selected itching, 6% selected that they have never seen a complication, and 14.9% specified other complications including: seroma, CSF leak, pump infection, catheter dislodge secondary to injury or lifestyle, infections around the pump, postdural puncture headache (PDPH), urinary retention, pump failure, sexual insufficiency, and bruising. More than half (59.4%) of respondents answered that they do prescribe oral antibiotics prophylactically after intrathecal pump implant while 40.6% said they do not. When asked if providers typically activated the patient controlled blousing option on the intrathecal pump, 32.9% of respondents said yes, 27% said no, 31.4% said sometimes, and 12 respondents specified if there were episodes of severe pain, if needed for better coverage of episodic pain, patient dependent, if the patient wants more control, if the continuous infusion and programmed boluses are not sufficient, for an active patient, and only for cancer pain if they answered “yes or sometimes”. A few (12.4%) respondents do not perform intrathecal pump refills; of those who do perform refills, 57.9% do by palpation, 20% using ultrasound (US), and 9.7% using fluoroscopy.

Table 4

Post-Intrathecal Pump Implantation

Question Asked
“Do you admit patients overnight after an intrathecal pump implant?”	Yes	No	Only if there is comorbidity
N = 136	41	73	22
“After implantation of the intrathecal pump, how frequently do you see respiratory depression as a side effect of intrathecal medications?”	Never	1–10%	11–20%	21–30%	31–40%	41–100%
N = 139	95	36	2	1	1	0
“What complications do you commonly encounter after intrathecal pump implantation?”(Select all)	Skin infection	Meningitis	Medication related complications	Urinary retention	Itching	Never seen a complication	Other
N = 134	45	4	35	40	57	8	20
“Do you prescribe oral antibiotic prophylaxis after intrathecal pump implant?”	Yes	No
N = 133	79	54
“Do you typically activate the patient controlled bolusing option on the intrathecal pump?”	Yes	No	Sometimes
N = 137	45	37	43
“How do you perform your intrathecal pump refils?”	I do not perform	By palpation	Using Ultrasound	Using fluoroscopy
N = 145	18	84	29	14

Discussion

The ASPN IDDS survey yielded a response from 159 providers with representation from greater than 5 specialties including anesthesiology, physiatry, neurosurgery, and neurology. Female representation constituted 16.9% of all survey responders while 82.4% were male. Most survey responders were within the age range of 31–60 years of age (84.8%) with 29.5% of responders being over the age of 50. This matches closely with the national trends of trainee and provider demographics in the United States. Of the 104 accredited pain medicine fellowships representing 372 fellowship positions, 21.8% of these positions were filled by female physicians with 1.6% being non-responders and 76.6% being male. Similarly, of the 115 neurosurgical residency programs with 1462 total residency positions, 17.3% of the positions were filled by female physicians while 82.0% were male and 0.7% not responding.7 A review of the 2019 Association of American Medical Colleges data show that female providers make up 19% of all active pain medicine physicians and 9.3% of all neurosurgeons.8 Further, the percentage of active physicians greater than 55 years of age, averaged across all specialties was 44.9%.9 Deviations from these numbers may be explained by the range of international responders (Canada 3.8%, Spain 3.1%, Mexico 1.3%, Saudi Arabia 1.3%) though most survey responses were from within the United States (84.3%). Approximately 48.5% of those surveyed have practiced for fewer than 10 years while 51.5% have practiced for greater than 10 years reflecting a wide spectrum of practice preferences.

In those surveyed, 84.9% of providers incorporate IDDS in their practice to some degree with 72.9% of providers performing intrathecal trials. Of those that do trials, the majority of providers perform a single shot intrathecal injection (78.3%) while 21.7% perform an indwelling epidural or intrathecal catheter for trial. The type of trial medication used and the admission status of single shot trial patients were not surveyed. Previous studies have found no superiority among trialing methods though the consensus recommendation was trials using opioids require inpatient overnight monitoring and single dose opioid trial is not considered best practice.10

Interestingly, of those that perform a continuous catheter trial, 70% admit the patient to the hospital while 30% send the patient home the same day. The American Society of Regional Anesthesia published a 2016 practice guidelines for prevention, detection, and management of respiratory depression associated with neuraxial opioid administration.11 Though not specific for IDDS and was more reflective of perioperative neuraxial opioid use, it was recommended for patients receiving lipophilic opioids to be monitored for at least 2 hours after administration with further monitoring as indicated by patient presentation. Twenty four hour monitoring was recommended for patients who were treated with hydrophilic opioids though no differences in frequency of respiratory depression, ventilatory response to carbon dioxide, somnolence or sedation was seen when single injection morphine was compared to fentanyl or sufentanil.11

Prior to trial, 55.6% of providers wean patients of systemic opioids. Though direct recommendations for oral opioid wean prior to trial or implant were not provided in the PACC guidelines, it was recommended to not use IDDS as a salvage therapy, implicating the need to avoid IDDS use as means of pain management when patients are refractory to care by high dose oral opioids.6 Future reviews have since taken a stronger stance to recommend preprocedural opioid wean to improve post implant IDDS outcomes.12

In those that perform trials, 19.7% of providers administer peri-procedural antibiotics and 10.2% prescribed post trial antibiotics. Best practices guidelines for IDDS were published by Prager et al in 2014 do not provide recommendations for periprocedural antibiotics use or post trial antibiotic course. In 2016, the Polyanalgesic Consensus Conference (PACC) published by Deer et al compiled recommendations to improve patient safety and IDDS efficacy.6 These guidelines do recommend antibiotic administration around the time of trials based on Center of Disease Control (CDC) grade IA and National Institute for Health and Care Excellence (NICE) recommendations but no post trial antibiotics beyond 24 hours.6 The variation in peri-trial antibiotic administration may reflect the prevalence of single shot trials over indwelling catheters.

Respiratory depression was never seen in the practice of 73.9% of the providers from trials while 21.0% has seen respiratory depression in less than 10% of all the trials they performed. Little data is available regarding respiratory depression after IDDS trial with opioids. In non-obstetric populations receiving neuraxial morphine (not specific for IDDS trial), the incidence of respiratory depression was quoted as 0.01–7.0%.13,14 The findings from this survey reflect this incidence though the breakdown of trialed medication used by providers were not reported here. Further, early respiratory depression (respiratory depression within 2 hours of administration) from intrathecal morphine have not been reported, though rare instances of delayed respiratory depression from cephalad migration of intrathecal morphine has been reported.15 Though formal studies have not been published, case reports have been reported detailing respiratory depression after intrathecal fentanyl administration, and a case series has been published detailing decreased respiratory rate with increased intrathecal fentanyl dosing though literature related to IDDS trial dosing is sparse.16,17

Independent pump implants are performed in 66.9% of those surveyed while 7.4% of responders implant in conjunction with neurosurgery. The predominant first choice medication utilized was morphine (63.3%) followed by hydromorphone (15.8%). This is similar to recommendations from PACC guidelines though ziconotide or baclofen use was not captured by this survey.5,6 The pump reservoir pocket was typically implanted in the abdomen (77.4%), low back (12.8%), or buttock (6.0%). Most providers (56.6%) only implant 20 mL pumps while 27.9% implant 40 mL pumps, and 15.4% implant both. The majority of those surveyed implant peristaltic rotor pump systems only (74.5%) or both the peristaltic rotor system and the valve gated bellow system (16.8%) in their practice while 6.6% only utilize the valve gated bellow system. There is no recommendation on pump or surgeon choice based on the survey responses.

Peri-implant antibiotics during surgical implant were used in 96.3% of providers which echo the trends and recommendations from the PACC guidelines and the CDC.6 Meanwhile oral post-operative antibiotics were utilized in 59.4% of those surveyed. This practice goes against the Surgical Care Improvement Project of the Joint Commissions (SCIP) recommendations that post-operative antibiotics are not needed 24 hours after the time of implant.18 Previous studies have shown that the rate of perioperative infection for implanted pain devices to range from 2.8% to 6%.19–21 Many IDDS are utilized in cancer patients who may have concomitant immunotherapy and may be immunocompromised. Studies have shown contrary to this belief, the rates of surgical site infection for pain implants are not greater in cancer patients compared to patients without cancer.19,22 However, a study by Hoelzer et al evaluating spinal cord stimulator implants did have a statistically significant decrease in incidence of surgical site infection with use of post-operative antibiotics for 7 days in non-cancer patients.23 This practice may reflect provider preference based on these findings.

Following implantation only 30.2% of patients are admitted for overnight monitoring while 16.2% of survey responders require overnight admission if patient comorbidities indicate this. Explanation for this trend was not provided by surveyors and only 2.9% of pumps were discharged with saline. The survey did not ask about concomitant naloxone prescriptions after implant but may explain the lower-than-expected overnight admission of chronic pain pumps. Further, not all implanted pumps were for pain. Approximately 7.9% of pumps were implanted for spasticity and 3.6% were implanted for category designation “other” which can further explain the discrepancy in actual admission rate compared to prior recommendations.6,10 Additionally, 70.4% of providers have never seen post implant respiratory depression while 16.7% have seen respiratory depression in less than 10% of patients with IDDS. This clinical experience may provide and influence survey responder’s decision against post implant 24-hour admission.

Common complications seen include pruritus (42.5%), skin infection (33.6%), and urinary retention (26.1%). These results vary from those published by Kamran et al where decreased libido was the most common complication followed by constipation and pruritus.24 Interestingly, superficial wound infection constituted only 3.1% of all complications in this study and urinary hesitancy was found in 9.2% of their patient complication cohort. Medication associated complications were noted by 26.1% of surveyed providers. These findings may reflect the prevalence of the complication seen across surveyed practices but not the true incidence of the complication in the surveyed cohort’s practice.

Once implanted, patient therapy manager or patient therapy controller was activated by 32.9% of providers while 31.5% activate this device “sometimes.” The variation in practice may reflect the question as it is vague whether activation refers to activation at the time of implant or activation over lifetime of the device. Thus, a larger percentage of providers may have selected “no” in reference for time of implant rather than lifetime of the device. The majority of providers that do refill their own IDDS (87.6%) do so by palpation (57.9%) or US (20.0%) while fluoroscopy was seldomly used (9.7%). It does appear education may be helpful to improve use of intrathecal boluses, especially for the management of pain.

The goal of this survey was to evaluate variations in intrathecal drug delivery systems practice characteristics across all providers. This was further achieved through various members of the interdisciplinary team being respondents, importantly so due to the pain management team built upon the collaboration of all providers represented in this survey.25

Limitations

Interpretation of the information from this survey should be performed with care. This survey’s small sample size needs to be considered as it consisted of only 159 participants and this could lead to potential response bias. The large difference in those who were sent the email and those who successfully received and opened the email may be partially attributed to incorrect or unused emails being on file for their ASPN accounts. Furthermore, the small response percentage, 9%, of those who successfully received and opened the email and completed the survey may reflect the small fraction of ASPN members who work with intrathecal drug delivery systems consistently as a part of their practice. Only 73.6% of survey respondents were board certified in pain medicine while 62.9% completed an ACGME accredited pain management fellowship and this also needs to be taken into consideration. These numbers can be partially explained by the 13.3% responder made up by non-attending physician providers (including physicians in training, APRN-NP’s, and PAs) who participated in this survey.

Conclusion

Many interventional pain physicians utilize some form of intrathecal drug delivery in their practice, however, this may only be a fraction of all pain management providers and ASPN members. There is variation most all aspects of intrathecal drug delivery systems from the health professionals providing the care to the actual pump used itself. The most common response for intrathecal drug delivery system main indication was chronic non-cancer pain, although cancer pain spasticity, and “other” were noted. The most reported first-choice medication in an intrathecal drug delivery system was morphine with the most common implant location of the pump being in the abdomen. Although this was a small sample size, a majority of the responding providers did not report serious complications; such as most having never seen respiratory depression as a side effect. This may add to current literature supporting the safety of intrathecal drug delivery systems. It must be noted that it is possible for response bias to be present due to the voluntary nature and small sample size of this survey. Further research into intrathecal drug delivery system practices should be sought out as this could help develop a more precise standard of care for the patients for needing this for adequate pain control.