Literature DB >> 3553107

The immunohistochemical demonstration of thyroglobulin in human thyroid tumour xenografts using a monoclonal antibody.

T C Richardson, S A Humm, T E Carr.   

Abstract

A monoclonal antibody (RBU/01) was raised against human thyroglobulin and its suitability for the immunohistochemical staining of thyroglobulin was determined on fixed, wax-embedded tissue, using the peroxidase anti-peroxidase (PAP) method. The antibody was then used to demonstrate the expression of human thyroglobulin in sections of a human follicular carcinoma of the thyroid which had been grown in immunodeficient mice. It is concluded that the immunohistochemical evaluation of the xenografts with the antibody provides useful information on this xenograft system as a potential model for thyroid carcinoma.

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Year:  1987        PMID: 3553107     DOI: 10.1007/BF00495007

Source DB:  PubMed          Journal:  Histochemistry        ISSN: 0301-5564


  5 in total

1.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors:  M M Bradford
Journal:  Anal Biochem       Date:  1976-05-07       Impact factor: 3.365

2.  Use of radiolabelled monoclonal anti-CEA antibodies for the detection of human carcinomas by external photoscanning and tomoscintigraphy.

Authors:  J P Mach; F Buchegger; M Forni; J Ritschard; C Berche; J D Lumbroso; M Schreyer; C Girardet; R S Accolla; S Carrel
Journal:  Immunol Today       Date:  1981-12

3.  Detection of thyroid tumours using radio-labelled anti-thyroglobulin.

Authors:  D S Fairweather; A R Bradwell; S F Watson-James; P W Dykes; S Chandler; R Hoffenberg
Journal:  Clin Endocrinol (Oxf)       Date:  1983-06       Impact factor: 3.478

4.  Diagnosis of primary thyroid carcinoma by immunohistological demonstration of thyroglobulin.

Authors:  A Burt; R B Goudie
Journal:  Histopathology       Date:  1979-07       Impact factor: 5.087

5.  The use of monoclonal antibodies against thyroglobulin in immunoperoxidase techniques.

Authors:  W Ormanns; R Schäffer
Journal:  Histochemistry       Date:  1983
  5 in total

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