Literature DB >> 3552717

Human gene therapy: possibilities and limitations.

H Müller.   

Abstract

Gene therapy provides new options for medicine, and implies new responsibilities for making decisions relating to the limitations which reason and morality impose upon manipulation of the human genome for the benefit both of patients and of society. This contribution outlines the possibilities and limits of gene therapy in man from a medico-technical viewpoint.

Entities:  

Mesh：

Year:  1987        PMID： 3552717     DOI： 10.1007/BF01940416

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  15 in total

1.  The transfer and stable integration of the HSV thymidine kinase gene into mouse cells.

Authors:  A Pellicer; M Wigler; R Axel; S Silverstein
Journal:  Cell       Date:  1978-05       Impact factor: 41.582

Review 2.  Transgenic mice.

Authors:  R D Palmiter; R L Brinster
Journal:  Cell       Date:  1985-06       Impact factor: 41.582

3.  Marrow transplantation for nonmalignant disorders.

Authors:  E D Thomas
Journal:  N Engl J Med       Date:  1985-01-03       Impact factor: 91.245

4.  Gene transfer in intact animals.

Authors:  M J Cline; H Stang; K Mercola; L Morse; R Ruprecht; J Brown; W Salser
Journal:  Nature       Date:  1980-04-03       Impact factor: 49.962

5.  Human in vitro fertilization and embryo transfer: expectations and concerns.

Authors:  H Müller
Journal:  Experientia       Date:  1985-12-15

6.  Expression of a bacterial gene in mammalian cells.

Authors:  R C Mulligan; P Berg
Journal:  Science       Date:  1980-09-19       Impact factor: 47.728

7.  Direct transfer of cloned genes from bacteria to mammalian cells.

Authors:  W Schaffner
Journal:  Proc Natl Acad Sci U S A       Date:  1980-04       Impact factor: 11.205

8.  Bone-marrow transplantation in the Maroteaux-Lamy syndrome (mucopolysaccharidosis type VI). Biochemical and clinical status 24 months after transplantation.

Authors:  W Krivit; M E Pierpont; K Ayaz; M Tsai; N K Ramsay; J H Kersey; S Weisdorf; R Sibley; D Snover; M M McGovern
Journal:  N Engl J Med       Date:  1984-12-20       Impact factor: 91.245

9.  Retrovirus-mediated transfer of human adenosine deaminase gene sequences into cells in culture and into murine hematopoietic cells in vivo.

Authors:  D A Williams; S H Orkin; R C Mulligan
Journal:  Proc Natl Acad Sci U S A       Date:  1986-04       Impact factor: 11.205

10.  The effect of chromosomal position on the expression of the Drosophila xanthine dehydrogenase gene.

Authors:  A C Spradling; G M Rubin
Journal:  Cell       Date:  1983-08       Impact factor: 41.582
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