Literature DB >> 6987538

Gene transfer in intact animals.

M J Cline, H Stang, K Mercola, L Morse, R Ruprecht, J Brown, W Salser.   

Abstract

Resistance to methotrexate was induced in bone marrow cells of mice by transformation in vitro with DNA from a drug-resistant cell line. Transformed cells were injected in vivo and haematopoietic cells expressing resistance were selected by drug treatment of recipients. Transformed cells had elevated levels of dihydrofolate reductase and demonstrated a proliferative advantage over untransformed cells, indicating successful gene transfer.

Entities:  

Mesh：

Substances：

Year:  1980        PMID： 6987538     DOI： 10.1038/284422a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  23 in total

Review 1.  Hematopoietic stem cell gene therapy.

Authors:  David W Emery; Tamon Nishino; Ken Murata; Michalis Fragkos; George Stamatoyannopoulos
Journal:  Int J Hematol       Date:  2002-04       Impact factor: 2.490

2.  High-frequency transfer of cloned herpes simplex virus type 1 sequences to mammalian cells by protoplast fusion.

Authors:  R M Sandri-Goldin; A L Goldin; M Levine; J C Glorioso
Journal:  Mol Cell Biol       Date:  1981-08       Impact factor: 4.272

3.  Generation of helper-free amphotropic retroviruses that transduce a dominant-acting, methotrexate-resistant dihydrofolate reductase gene.

Authors:  A D Miller; M F Law; I M Verma
Journal:  Mol Cell Biol       Date:  1985-03       Impact factor: 4.272

4.  Somatic gene therapy. Current status and future prospects.

Authors:  D A Williams; S H Orkin
Journal:  J Clin Invest       Date:  1986-04       Impact factor: 14.808

5.  Direct introduction of genes into rats and expression of the genes.

Authors:  N Benvenisty; L Reshef
Journal:  Proc Natl Acad Sci U S A       Date:  1986-12       Impact factor: 11.205

6.  Recovery of recombinant bacterial plasmids from E. coli transformed with DNA from microinjected mouse cells.

Authors:  P J Kretschmer; A H Bowman; M H Huberman; L Sanders-Haigh; L Killos; W F Anderson
Journal:  Nucleic Acids Res       Date:  1981-11-25       Impact factor: 16.971

7.  Molecular biology in medicine.

Authors:  M J Duffy
Journal:  Ir J Med Sci       Date:  1982-04       Impact factor: 1.568

Review 8.  Human gene therapy: possibilities and limitations.

Authors:  H Müller
Journal:  Experientia       Date:  1987-04-15

9.  Evaluation of the probability of spontaneous transfer of drug resistance between cells in culture.

Authors:  C K Luk; I F Tannock
Journal:  In Vitro Cell Dev Biol       Date:  1991-03

10.  Gene therapy.

Authors:  M J Cline
Journal:  Mol Cell Biochem       Date:  1984       Impact factor: 3.396
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.