Yanhui Li1,2, Di Gao1,2, Jieyu Liu1,2, Zhaogeng Yang1,2, Bo Wen1,2, Li Chen1,2, Manman Chen1,2, Ying Ma1,2, Tao Ma1,2, Bin Dong1,2, Yi Song1,2, Sizhe Huang3, Yanhui Dong4,5, Jun Ma6,7. 1. Institute of Child and Adolescent Health, School of Public Health, Peking University, 100191, Beijing, China. 2. National Health Commission Key Laboratory of Reproductive Health, 100191, Beijing, China. 3. Zhongshan Health Care Centers for Primary and Secondary School, 528403, Zhongshan, China. 4. Institute of Child and Adolescent Health, School of Public Health, Peking University, 100191, Beijing, China. dongyanhui@bjmu.edu.cn. 5. National Health Commission Key Laboratory of Reproductive Health, 100191, Beijing, China. dongyanhui@bjmu.edu.cn. 6. Institute of Child and Adolescent Health, School of Public Health, Peking University, 100191, Beijing, China. majunt@bjmu.edu.cn. 7. National Health Commission Key Laboratory of Reproductive Health, 100191, Beijing, China. majunt@bjmu.edu.cn.
Abstract
OBJECTIVE: To assess the effects of prepubertal BMI on pubertal growth patterns, and the influence of prepubertal BMI and pubertal growth patterns on long-term BMI among Chinese children and adolescents. METHODS: A total of 9606 individuals aged between 7 and 18 years from longitudinal surveys in Zhongshan city of China from 2005 to 2016 were enrolled. Age at peak height velocity (APHV) and peak height velocity (PHV) were estimated using Super-Imposition by Translation and Rotation (SITAR) model. Associations between prepubertal BMI, APHV, PHV, and long-term overweight and obesity were assessed by linear regression and multinominal logistic regression. Scatter plots were elaborated to show the associations between prepubertal BMI and pubertal growth patterns according to prepubertal BMI categories. RESULTS: Prepubertal BMI Z-Score was positively correlated with long-term BMI Z-Score, and negatively correlated with APHV in both sexes. In addition, there was a negative association between prepubertal BMI Z-Score and PHV in boys. With 1-year decrease in APHV, risk of long-term underweight decreased by 92%, while overweight increased by 33% in boys. Corresponding risk of long-term underweight and overweight for girls decreased by 42% and increased by 20%, respectively. CONCLUSION: High prepubertal BMI levels were associated with earlier APHV and lower PHV, and the early onset of pubertal development could increase the risks of long-term overweight and obesity at 17-18 years of age both in boys and girls. Such evidence emphasized the importance of reducing prepubertal obesity risks combined with appropriate pubertal development timing, including later APHV and higher PHV, so as to prevent the obesity and related cardiovascular diseases in adulthood.
OBJECTIVE: To assess the effects of prepubertal BMI on pubertal growth patterns, and the influence of prepubertal BMI and pubertal growth patterns on long-term BMI among Chinese children and adolescents. METHODS: A total of 9606 individuals aged between 7 and 18 years from longitudinal surveys in Zhongshan city of China from 2005 to 2016 were enrolled. Age at peak height velocity (APHV) and peak height velocity (PHV) were estimated using Super-Imposition by Translation and Rotation (SITAR) model. Associations between prepubertal BMI, APHV, PHV, and long-term overweight and obesity were assessed by linear regression and multinominal logistic regression. Scatter plots were elaborated to show the associations between prepubertal BMI and pubertal growth patterns according to prepubertal BMI categories. RESULTS: Prepubertal BMI Z-Score was positively correlated with long-term BMI Z-Score, and negatively correlated with APHV in both sexes. In addition, there was a negative association between prepubertal BMI Z-Score and PHV in boys. With 1-year decrease in APHV, risk of long-term underweight decreased by 92%, while overweight increased by 33% in boys. Corresponding risk of long-term underweight and overweight for girls decreased by 42% and increased by 20%, respectively. CONCLUSION: High prepubertal BMI levels were associated with earlier APHV and lower PHV, and the early onset of pubertal development could increase the risks of long-term overweight and obesity at 17-18 years of age both in boys and girls. Such evidence emphasized the importance of reducing prepubertal obesity risks combined with appropriate pubertal development timing, including later APHV and higher PHV, so as to prevent the obesity and related cardiovascular diseases in adulthood.
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