| Literature DB >> 35520095 |
Anne Tjønndal1, Stian Røsten1.
Abstract
Sports injury prevention is an important part of the athlete welfare and safeguarding research field. In sports injury prevention, sport-related concussion (SRC) has proved to be one of the most difficult and complex injuries to manage in terms of prevention, diagnosis, classification, treatment and rehabilitation. SRC can cause long-term health issues and is a commonly reported injury in both adult and youth athletes around the world. Despite increased knowledge of the prevalence of SRC, very few tools are available for diagnosing SRC in athletic settings. Recent technological innovations have resulted in different machine learning and deep learning methodologies being tested to improve the management of this complex sports injury. The purpose of this article is to summarize and map the existing research literature on the use of machine learning in the management of SRC, ascertain where there are gaps in the existing research and identify recommendations for future research. This is explored through a scoping review. A systematic search in the three electronic databases SPORTDiscus, PubMed and Scopus identified an initial 522 studies, of which 24 were included in the final review, the majority of which focused on machine learning for the prediction and prevention of SRC (N = 10), or machine learning for the diagnosis and classification of SRC (N = 11). Only 3 studies explored machine learning approaches for the treatment and rehabilitation of SRC. A main finding is that current research highlights promising practical uses (e.g., more accurate and rapid injury assessment or return-to-sport participation criteria) of machine learning in the management of SRC. The review also revealed a narrow research focus in the existing literature. As current research is primarily conducted on male adolescents or adults from team sports in North America there is an urgent need to include wider demographics in more diverse samples and sports contexts in the machine learning algorithms. If research datasets continue to be based on narrow samples of athletes, the development of any new diagnostic and predictive tools for SRC emerging from this research will be at risk. Today, these risks appear to mainly affect the health and safety of female athletes.Entities:
Keywords: athlete welfare; deep learning; machine learning; sport and health; sport injury prevention; sport technologies; sports-related concussion (SRC)
Year: 2022 PMID: 35520095 PMCID: PMC9067303 DOI: 10.3389/fspor.2022.837643
Source DB: PubMed Journal: Front Sports Act Living ISSN: 2624-9367
Figure 1Flow chart of the scoping review process, adapted from Page et al. (2021).
Results of the scoping review.
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| Bazarian et al. ( | Validate classification accuracy of the concussion index in athletes. | Prospective cohort study between February 2017 and March 2019. Multimodal, EEG based Concussion Index including cognitive testing and symptom inventories. ML-method: The genetic algorithm. | Concussion index has high classification accuracy for identification of the likelihood of concussion at time of injury. Potential to aid in the clinical diagnosis of concussion and in the assessment of athletes' readiness to return to play. | |
| Bergeron et al. ( | ML-approach to estimate symptom resolve time within 7, 14 and 28 days in high school athletes with SRC. | Data from the National Athletic Treatment, Injury and Network (NATION) injury surveillance program (2011–2014) from 147 high schools in 26 states. | Cohort study. Symptoms were recorded based on responses to an administered 17-item yes/no checklist. Created three distinct category thresholds of symptom resolution time; within 7, 14, and 28 d. ML-method: 10 classification algorithms considered (Naïve Bayes (NB), support vector machine (SVM), 5-nearest neighbors (5NN), C4.5 Decision Tree (C4.5D and C4.5N), Random Forest (RF100 and RF500), multilayer perceptron and radial basis function network). | ML demonstrated efficacy, while warranting further exploration, in developing symptom-based prediction models for practical estimation of SRC recovery in enhancing clinical decision support. |
| Bohsra et al. ( | Investigate the extent to which our present understanding of how mTBI affects brain activity and can be used to detect past concussions. | Three paradigm experiments. Self-report questionnaires, EEG Recording and pre-processing (Brain Vision Analyzer). ML-method: Support Vector Machines (SVMs). | A combination of statistics of single-subject ERPs and wavelet features yielded a classification accuracy of 81% with a sensitivity of 82% and a specificity of 80%, improving on current practice. The model was able to detect concussion effects in individuals who sustained their last injury as much as 45 years earlier. | |
| Cai et al. ( | Develop an accurate and reliable injury predictor for concussion classification. | Voxel-wise WM fiber strains from the brain as implicit features for concussion prediction ML-method: SVM and RF as baseline classifiers to benchmark the performance of deep learning. ML-method: deep learning network. | ML classifiers and deep learning outperformed all scalar injury metrics across all performance categories. These findings demonstrate the superior performances of deep learning in concussion prediction and suggest its promise for future applications in biomechanical investigations of TBI. | |
| Cao et al. ( | Use ML to detect residual functional abnormalities at 30-day postinjury with multichannel EEG data. | Multichannel EEG set under multiple conditions for assessments. ML-method: Support vector machine (SVM) to identify athletes who suffer from residual functional deficits after SRC. | SVM may be potentially used in clinical practice for automatic classification of athletes with residual brain functional abnormalities following a concussion episode. | |
| Castellanos et al. ( | Develop a predictive model for sport-related concussion. | Prospective design; Data from the CARE Consortium Study between the 2015 to 2016 academic year. Participants completed Level A (e.g., demographics, SCAT Symptom Checklist) and B (e.g., reaction time, quality of life) measures. Baseline data from 176 covariates including 957 features. ML-method: A linear support vector machine (SVM) to stratify subjects' risk for SRC based on baseline data. | The model identifies athletes and cadets who would go on to sustain SRC with comparable accuracy to many existing assessment tools and provides insights into potential risk and protective factors. | |
| DiCesare et al. ( | Examine whether ML classification of sensor-recorded head impacts could produce a more accurate quantification of season-long sub-concussive head impacts (SCIs) exposure, and whether this would result in pronounced associations between SCI exposure and longitudinal changes to white matter (WM) microstructure. | Prospective cohort study. Analyze; pre- and post-season MRI-scans ( | The ML classifier performed best and provided a superior means for removing spurious recordings and allowed for greater sensitivity in exploring and quantifying the relationship between SCI exposure and longitudinal changes of WM and head impacts. | |
| Domel et al. ( | Present a deep learning algorithm (MiGNet) to differentiate between true and false head impacts for an instrumented mouthguard sensor (MiG2.0), and compare the predictive power between MigNet and support vector machine (SVM). | Cohort study. Measures; an instrumented mouthguard for measuring linear and angular head kinematics during impacts. Included video to verify head impacts (358 true and 500 false). ML-method: MigNet (a neural network classifier) and SVM. | MigNet (96% accuracy) perform better compared to SVM (91% accuracy). | |
| Falcone et al. ( | Explore the feasibility of using speech analysis and ML for detecting whether an athlete is concussed. | Cohort study over the course of pre-, during and post-assessments in a boxing tournament. Data from a mobile application test and based on speaking a fixed sequence of digits that appeared on screen every 1.5 s for 30 s. ML-method: Support Vector Machine (SVM). | Prediction results were verified against the diagnoses made by a ringside medical team and performance evaluation shows prediction accuracies of up to 98.2% and precisions up to 78.8% This indicates that speech analysis in combination with ML could be beneficial to identify suspected concussion cases. | |
| Fedorchak et al. ( | Assess the ability of salivary non-coding ribonucleic acids (ncRNA) levels to predict post-concussion symptoms (PPCS). | Cohort study and experimental design: the sample divided into two groups based on self-reported symptom scores (PPCS = 32, and non-PPCS = 80). Measures: medical/demographic characteristics via survey at enrolment, ncRNA collected ≤ 14 days post-injury, and follow-up ≥ 21 days post-injury. Balance and cognitive test performance were assessed at both these time-points. ML-method: a radial support vector machine (rSVM) algorithm. | The performance of model predicting PPCS status when measuring ncRNA within 14 days of concussion achieved an AUC of 0.83 and was superior to the modified clinical risk score (AUC= 0.73). Saliva ncRNAs biomarkers measured within 14 days of mTBI provide prognostic information about risk for PPCS, tracing recovery and predicting who will have prolonged symptoms. | |
| Ferris et al. ( | Examine the validity of Vestibular/Ocular-Motor Screening (VOMS) assessment tool and utilize machine learning to deduce the additive power of the VOMS in relation to components of the Sport Concussion Assessment Tool 3 (SCAT3) for SRC detection. | Cohort-study; Data from National Collegiate Athletic Association–Department of Defense Concussion Assessment, Research and Education (CARE) Consortium. Measures: preseason and acute postinjury assessments including modified SCAT3 and VOMS. ML-method: an Ada Boosted Tree machine learning model. | Incorporation of VOMS into the full SCAT3 significantly boosted overall diagnostic ability by 4.4% (AUC = 0.848) and produced a 9% improvement in test sensitivity and 3% specificity over the existing SCAT3 battery. The results from this study highlight the utility of the VOMS tool in acute concussion assessments. | |
| Gabler et al. ( | Develop and evaluate a broad range of ML model algorithms and predictive features for their ability to discriminate between head impacts and spurious events. | Cohort study over the course of 11 games during the fall 2018 and 2019 seasons. Measures; an instrumented mouthguard for measuring linear and angular head kinematics during impacts. Included video to verify and assessments of head impacts. Five different ML model algorithm classes were considered; Classification and Regression Tree (CART), Adaboost, XGBoost, The Random Forrest and Support Vector Machine (SVM). | All the five models revealed good performance filtering head impacts from spurious events on training dataset from 2018 season (precision = 91.7–95.9%). The results highlight the potential efficacy of the mouthguard sensor for detecting 81.6% of the head impacts confirmed on video, while the ML classifier achieved 100% recall at 98.3% precision. This indicates using sensor and ML model is promising for classifying head impacts in football. | |
| Goswami et al. ( | Examine the uncinate fasciculus (UF) and connected gray matter in relation to behavioral changes in retried professional athletes with multiple concussions. Furthermore, to use ML to test the predictive power of diffusion imaging metrics within the UF to discriminate concussed athletes from controls. | Explorative design. Measures; neuropsychological assessments, neuroimaging (MRI) and cortical thickness analysis (CTA) to assess gray matter. ML-method: SVM classifiers | UF diffusion imaging differentiates athletes from healthy controls. These implicate the UF system in the pathological outcomes of repeated concussion as they relate to impulsive behavior. Furthermore, a SVM has potential utility in the general assessment and diagnosis of brain abnormalities following concussion. | |
| Helfer et al. ( | Develop an easily obtainable biomarker for detecting cognitive change by using formant track dynamics and coordination. | Cohort study; pre-, in- and postseason data. Measures; Multimodal Early Detection Interactive Classifier (MEDIC) system. Includes scores from a series of cognitive tests (ImPACT), along with speech features extracted from audio recordings from a standardized read passage. ML-method: A SVM-based classifier. | Findings demonstrate the use of vocal features during read speech to detect changes in cognitive ability. Detecting changes in cognitive status has potential benefit, in that cognitive changes have been shown to arise prior to clinically diagnosed concussions. Furthermore, the high detection rate of the classifier suggests it could be used as a screening tool to determine readiness to RTP thereby lowering the subject's risk of subsequent injury. | |
| McNerny et al. ( | Evaluate the accuracy and potential benefit of including EEG measurements in a system that could provide an immediate objective mTBI assessment. | Questionnaire, behavioral tests and resting-state EEG using three frontopolar electrodes. ML-method: TotalBoost algorithm (analysis: leave-one-out-cross-validation). | The addition of EEG measurements boosted the accuracy to approximately 91 ± 2% compared to 82 ± 4% from the symptom questionnaire alone. This demonstrates the potential benefit of including EEG measurements to diagnose suspected mTBI. A step toward accurate and objective classification measurements that can be implemented on the field as a future injury assessment tool. | |
| Raji et al. ( | Determine whether edge density imaging from MR can separate pediatric mTBI from typically developing controls. | Experimental design. Measurements; neurocognitive assessments including the pediatric version of the California Verbal Learning Test (CVLT) and the Attention Network Task (ANT), and magnetic resonance imaging (MRI) scan/assessments. ML-method: Support vector machine (SVM) using linear kernels (analysis; ROC and leave-one-out cross-validation). | SVM-principal component analysis of edge density imaging maps identified three white matter regions distinguishing pediatric mild TBI from controls. This show that edge density imaging is a new form of connectome mapping that provides better diagnostic delineation between pediatric mild TBI and healthy controls than neurocognitive assessments of memory or attention. | |
| Reynolds et al. ( | Use rs-fMRI data to assess effects of subconcussion on metrics thought to represent functional brain connectivity. | Cohort study; pre- and postseason testing. Measurements; resting-state functional magnetic resonance imaging (rs-fMRI) to assess changes in the brain. ML-method: A linear support vector machine (SVM) classifier. | The paired SVM only found significantly high-class accuracy for preseason-to-postseason ReHo changes in the college football players (87%, | |
| Seeger et al. ( | Examine the utility of salivary inflammatory markers following SRC to predict symptom burden and length of return to sport (RTS). | Prospective exploratory cohort study. Measurements; saliva samples collected within 72 h of injury and analyzed for cytokines. In addition, participants' characteristics, length of RTP and symptom burden using SCAT3. ML-method: The RReliefF feature ranking algorithm. | The ML models used provided a specific cytokine profile in conjunction with sex and a previous concussion history that significantly correlated actual to predicted scores for the number of symptoms and symptom severity but not RTS. From these data, saliva cytokines hold promise as a method to identify fluid biomarker profiles for predicting symptom burden following SRC. | |
| Shim et al. ( | Propose a framework that combines fine element (FE) analysis with a machine learning approach to simulate mTBI as a result of a direct impact to the head for rapid prediction of brain damage pattern after mTBI. | Experiment using data from cohort study (pre-, during- and postseason). Measurements; magnetic resonance imaging (MRI) scan to develop a fine element model of the brain. ML-method: A Partial Least Squares Regression (PLSR) model using data from different brain impact scenarios. | The PLSR trained model was able to predict the general principal strain distribution patterns as well as the location and magnitude of peak strains with an accuracy of 95% and computational time of <10 s. This may play an important role in developing an objective diagnostic tool for mTBI that can predict the severity of head impact. | |
| Thanjavur et al. ( | Develop a deep learning long short-term memory (LSTM)-based recurrent neural network that is able to distinguish between non-concussed and post-concussed adolescent athletes using samples of resting-state electroencephalography (EEG). | Explorative design. Measurements; resting-state electroencephalography (EEG) recordings as input. ML-method: A deep learning long short-term memory (LSTM)-based recurrent neural network classifier (ConcNet). | The ConcNet classifier consistently identified concussions with an accuracy of > 90%. It correctly identified the concussed participants and misclassified only a small number of controls. This represents a promising first step toward the development of an easy-to-use, objective, brain-based, automatic classification of concussion at an individual level. | |
| Tremblay et al. ( | Characterize the | Experimental design. Measurements; neuropsychological testing, genotyping, and multimodal neuroimaging evaluation. ML-methods: four different classifiers. A linear Support Vector Machine (SVM), A Step-wise Penalized Logistic Regression, a Random Forest and a LogitBoost. | ML classifiers trained to detect remote concussions achieved detection accuracies up to 90%. | |
| Visscher et al. ( | Explore the use of ML for novel insights into the differences in phenotypes between patients with concussions based on objective vestibular and balance performance. | N= 96 subjects suspected of suffering from a SRC or PCS (78 males and 18 females). Age: N.R. Sports: ice hockey, ski, snowboard, handball, soccer. Region: Europe, Switzerland | Exploratory study. Measurements; balance and vestibular diagnostic testing, as well as epidemiological and symptoms data used for cluster analysis ( | The SOM divided the data into one group with prominent vestibular disorders and another with no clear vestibular or balance problems, suggesting that artificial intelligence might help improve the diagnostic process. This study could be helpful in the future for improving assessment batteries and diagnostic criteria. |
| Wu et al. ( | Develop a deep learning neural network to estimate reginal brain strains instantly and accurately using data from head impact sensors. | Real-world datasets (measured/ reconstructed) collected from head impact sensors ( | Exploratory design. Measurements; head impact sensors converted into three regional brain strains. ML-method: A convolutional neural network (CNN) to convert a head impact measured (10-fold cross-validation). | The CNN estimated regional brain stains with sufficient accuracy. Together with sensors that measure impact kinematics, the CNN may enable a sophisticated head injury model to produce region-specific brain responses, instantly. Therefore, this technique may offer clinical diagnostic values to facilitate head impact sensors in concussion detection |
| Zhuang et al. ( | Simulation of force impacts with bowling bowl on a single FBG-embedded smart helmet prototype (football). | Development of new sports equipment (protective head gear). | Exploratory. Development of a smart helmet with a single embedded fiber Bragg grating (FBG) sensor for real-time sensing of blunt-force impact events to helmets. ML-method: 7 machine learning models were considered [Support Vector Machine (SVM), Gaussian Process Regression (GPR), Random Forest (RF), K-Nearest Neighbor Instance-Based Learner (IBK), Elastic Net Regression (ENR), Voting, and Additive Regression-Random Forest (AR-RF)]. | The FBG-embedded smart helmet prototype successfully achieved real-time sensing of concussive events. The use of ML-FBG smart helmet systems can serve as an early-stage intervention strategy during and immediately following a concussive event. |
Study characteristics of the reviewed literature.
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| Athlete gender | Female | 1 |
| Male | 8 | |
| Mixed | 10 | |
| Not reported | 5 | |
| Athlete age | Child (3–5) | - |
| Youth (6–11) | - | |
| Adolescent (12–18) | 5 | |
| Adult (19+) | 4 | |
| Mixed youth and adolescent | - | |
| Mixed adolescent and adult | 3 | |
| Mixed youth, adolescent and adult | 2 | |
| Not reported | 10 | |
| Sports | Boxing | 1 |
| Football | 7 | |
| Ice hockey | 1 | |
| Soccer | 1 | |
| Mixed | 11 | |
| Not reported | 3 | |
| Region sample is recruited from | North America | 22 |
| Europe | 1 | |
| Not reported | 1 | |
| Sample size | <20 | - |
| 20–50 | 10 | |
| 51–100 | 5 | |
| 101–200 | 2 | |
| 201–500 | 1 | |
| >501 | 2 | |
| Not reported | 4 |
Reviewed literature by journal and year of publication.
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| Annals of Biomedical Engineering | 2 | 2 | |||
| Brain Imaging and Behavior | 1 | 1 | |||
| Brain Structure and Function | 1 | 1 | |||
| European Journal of Neuroscience | 1 | 1 | |||
| IEEE Access | 1 | 1 | |||
| IEEE International Conference on Acoustics, Speech, and Signal Processing | 1 | 1 | |||
| IEEE Transactions on Neural Systems and Rehabilitation Engineering | 1 | 1 | 2 | ||
| ISCA Proceedings of Interspeech | 1 | 1 | |||
| JAMA Network Open | 1 | 1 | |||
| Journal of Neurology | 1 | 1 | |||
| Journal of Neuroscience Methods | 1 | 1 | |||
| Medicine & Science in Sports & Exercise | 1 | 1 | |||
| Pediatric Radiology | 1 | 1 | |||
| PLoS ONE | 2 | 2 | |||
| Scientific Reports | 1 | 2 | 3 | ||
| Sports Medicine | 1 | 1 | |||
| Sports Medicine - Open | 1 | 1 | |||
| The American Journal of Sports Medicine | 1 | 1 | |||
| The Journal of Head Trauma Rehabilitation | 1 | 1 |