| Literature DB >> 35519254 |
Pei-Chun Wu1,2,3,4, Lun-Zhang Guo2,4, Shan Yu1,5,4, Ning Zeng6,7,4, Yu-Cheng Liu1, Jia Yu1, Zhiming Zhang1, Ke Lu1, Liangyu Sun1, Chunfei Wang1, Yu-Han Chang2,3, Yin-Lin Lu1,3, Yu-Fang Shen8,9, Sheng Tai10, Yueh-Hsun Chuang11, Ja-An Annie Ho12, Kai-Wen Huang13, Yao-Ming Wu14, Tzu-Ming Liu1.
Abstract
Using in vivo multiphoton fluorescent dosimetry, we demonstrate that the clearance dynamics of Indocyanine Green (ICG) in the blood can quickly reveal liver function reserve. In normal rats, the ICG retention rate was below 10% at the 15-minute post-administration; While in the rat with severe hepatocellular carcinoma (HCC), the 15-minute retention rate is over 40% due to poor liver metabolism. With a 785 nm CW laser, the fluorescence dosimeter can evaluate the liver function reserve at a 1/10 clinical dosage of ICG without any blood sampling. In the future, this low-dosage ICG 15-minute retention dosimetry can be applied for the preoperative assessment of hepatectomy or timely perioperative examination.Entities:
Year: 2022 PMID： 35519254 PMCID： PMC9045906 DOI： 10.1364/BOE.446749
Source DB: PubMed Journal: Biomed Opt Express ISSN： 2156-7085 Impact factor: 3.562