Literature DB >> 3551835

Impaired clearance of ceftizoxime and cefotaxime after orthotopic liver transplantation.

G J Burckart, R J Ptachcinski, D H Jones, D L Howrie, R Venkataramanan, T E Starzl.   

Abstract

The pharmacokinetics of ceftizoxime (CZX) and of cefotaxime (CTX) were studied in five children and five adults after orthotopic liver transplantation (OLT). Delayed clearance of CZX (clearance of 0.21 to 1.26 ml/min per kg [body weight]) and CTX (clearance of 0.40 to 1.49 ml/min per kg) occurred in 7 of the 10 OLT patients. We conclude that abnormal CZX and CTX clearance is common after OLT and may be associated with minimal change in serum creatinine.

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Year:  1987        PMID： 3551835      PMCID： PMC174715          DOI： 10.1128/AAC.31.2.323

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  3 in total

1.  Computation of model-independent pharmacokinetic parameters during multiple dosing.

Authors:  L A Bauer; M Gibaldi
Journal:  J Pharm Sci       Date:  1983-08       Impact factor: 3.534

2.  Cefotaxime and desacetyl cefotaxime kinetics in renal impairment.

Authors:  G R Matzke; P A Abraham; C E Halstenson; W F Keane
Journal:  Clin Pharmacol Ther       Date:  1985-07       Impact factor: 6.875

3.  Pharmacology of cefotaxime and its desacetyl metabolite in renal and hepatic disease.

Authors:  R Wise; N Wright; P J Wills
Journal:  Antimicrob Agents Chemother       Date:  1981-04       Impact factor: 5.191
  3 in total
  5 in total

Review 1.  Cefotaxime. An update of its pharmacology and therapeutic use.

Authors:  P A Todd; R N Brogden
Journal:  Drugs       Date:  1990-10       Impact factor: 9.546

Review 2.  Cefotaxime. A reappraisal of its antibacterial activity and pharmacokinetic properties, and a review of its therapeutic efficacy when administered twice daily for the treatment of mild to moderate infections.

Authors:  R N Brogden; C M Spencer
Journal:  Drugs       Date:  1997-03       Impact factor: 9.546

3.  Comparative study of pharmacokinetics and serum bactericidal activity of ceftizoxime and cefotaxime.

Authors:  F Vallée; M LeBel
Journal:  Antimicrob Agents Chemother       Date:  1991-10       Impact factor: 5.191

4.  Microbiological efficacy and pharmacokinetics of prophylactic antibiotics in liver transplant patients.

Authors:  P M Arnow; K Furmaga; J P Flaherty; D George
Journal:  Antimicrob Agents Chemother       Date:  1992-10       Impact factor: 5.191

Review 5.  Clinical pharmacokinetics in organ transplant patients.

Authors:  R Venkataramanan; K Habucky; G J Burckart; R J Ptachcinski
Journal:  Clin Pharmacokinet       Date:  1989-03       Impact factor: 6.447
  5 in total

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