Literature DB >> 35516164

Estimating surge in COVID-19 cases, hospital resources and PPE demand with the interactive and locally-informed COVID-19 Health System Capacity Planning Tool.

Olga Krylova1, Omar Kazmi1, Hui Wang1, Kelvin Lam1, Chloe Logar-Henderson1, Katerina Gapanenko1.   

Abstract

Introduction: The COVID-19 pandemic revealed an urgent need for analytic tools to help health system leaders plan for surges in hospital capacity. Our objective was to develop a practical and locally informed Tool to help explore the effects of public health interventions on SARS-CoV-2 transmission and create scenarios to project potential surges in hospital admissions and resource demand.
Methods: Our Excel-based Tool uses a modified S(usceptible)-E(xposed)-I(nfected)-R(emoved) model with vaccination to simulate the potential spread of COVID-19 cases in the community and subsequent demand for hospitalizations, intensive care unit beds, ventilators, health care workers, and personal protective equipment. With over 40+ customizable parameters, planners can adapt the Tool to their jurisdiction and changes in the pandemic.
Results: We showcase the Tool using data for Ontario, Canada. Using healthcare utilization data to fit hospitalizations and ICU cases, we illustrate how public health interventions influenced the COVID-19 reproduction number and case counts. We also demonstrate the Tool's ability to project a potential epidemic trajectory and subsequent demand for hospital resources. Using local data, we built three planning scenarios for Ontario for a 3-month period. Our worst-case scenario accurately projected the surge in critical care demand that overwhelmed hospital capacity in Ontario during Spring 2021. Conclusions: Our Tool can help different levels of health authorities plan their response to the pandemic. The main differentiators between this Tool and other existing tools include its ease of use, ability to build scenarios, and that it provides immediate outcomes that are ready to share with executive decision makers. The Tool is used by provincial health ministries, public health departments, and hospitals to make operational decisions and communicate possible scenarios to the public. The Tool provides educational value for the healthcare community and can be adapted for existing and emerging diseases.

Entities:  

Keywords:  COVID-19; PPE demand; epidemiology; health policy; health system capacity; hospital bed demand; infectious diseases; interactive tool; predictive modeling; public health; statistics and research methods

Mesh:

Year:  2022        PMID: 35516164      PMCID: PMC9052960          DOI: 10.23889/ijpds.v5i4.1710

Source DB:  PubMed          Journal:  Int J Popul Data Sci        ISSN: 2399-4908


Introduction

The Coronavirus Disease 2019 (COVID-19) pandemic has put unprecedented pressure on healthcare systems in Canada [1] and around the world [2]. Health leaders have sought models to provide short- and long-term forecasts of COVID-19 cases [3-5], demand for hospital resources [5-7], and the potential impact of public health interventions [5, 8, 9]. Many analytical models have been developed [5, 6, 10–12] to help decision makers plan for the pandemic. However, they are predominantly based on sophisticated software packages and require advanced knowledge and technical skills to use. To meet the planning needs of hospital managers, public health units and provincial health ministries in March 2020, we started developing the COVID-19 Health System Capacity Planning Tool (referred to as the Tool) with flexible and user-friendly features. By simulating the impact of various public health interventions, the Tool models SARS-CoV-2 transmission in the population and provides scenario-based projections for acute and critical care beds, ventilators, health care worker (HCW) staffing, and personal protective equipment (PPE) needed to care for patients with COVID-19. Designed for users with different levels of knowledge, the Tool uses the same underlying mathematical models as most other tools, but is Excel-based with parameter inputs, data outputs, and visualizations that are simple to understand, modify, and adapt to local contexts. The impact of COVID-19 has been felt across Canada, but provinces and territories have experienced differences in disease burden, timing, and number of waves, and in the implementation of policies to prevent the spread of the virus [13, 14]. Our Tool contains over 40 customizable parameters, enabling decision-makers at all levels to create local scenarios and plan for surges in health resource demands and supply shortfalls associated with the COVID-19 pandemic in their region. The Tool has been used successfully by provincial health ministries, public health departments and hospitals across Canada to make operational decisions and inform the public about potential scenarios. The Tool continues to evolve to reflect changes in our understanding of SARS-CoV-2 transmission as new variants of concern (VOCs) emerge and vaccination rollouts offer hope in defeating this virus. In the following sections, we present our underlying methodology, data sources and parameters, and results by applying the Tool to data from Ontario, Canada. Ontario is Canada’s largest province, has the country’s largest number of confirmed COVID-19 cases [13], and has easily accessible COVID-19 data.

Methods

Tool development and framework

During the early stage of the pandemic, our team engaged and exchanged information with the Public Health Agency of Canada, ministries of health, modelling experts in the academic community, hospitals, regional health authorities, and public health units to develop and shape this Tool. For modelling transparency, simplicity and ease of use, we implemented the Tool in Microsoft Excel. It is available to potential users upon request by contacting the Canadian Institute for Health Information (help@cihi.ca). The COVID-19 Health System Capacity Planning Tool covers the major aspects of COVID-19 health capacity planning in one model, from forecasting epidemic trajectories to hospital bed supply and demand to PPE and staffing needs. Our Tool has three interconnected modules: the Epidemiological (Epi) module, Capacity module and HCW/PPE module (Figure 1, detailed description provided in Appendix A1). The Epi module simulates the potential spread of COVID-19 cases, considering local public health measures, transmissibility, and vaccination rates. The Capacity and HCW/PPE modules estimate hospital resources and the number of healthcare workers and PPE required to treat COVID-19 patients, respectively.
Figure 1: Flowchart for the

Model

Epi module

The Epi module simulates the potential spread of COVID-19 cases in a previously unexposed population. This module requires users to input locally derived data such as cumulative COVID-19 cases, population size, dates of public health measures, and vaccination rates. The Epi module was built using a modified version of the Susceptible-Exposed-Infected-Removed-type deterministic compartmental model with vaccination [15-18]. To implement this model in Excel we used a discrete-time version of the model [19]. The Epi module in Figure 1 (teal box) illustrates how individuals in the population move across compartments according to the stages of COVID-19 progression. For example, someone could be susceptible to infection, an asymptomatic infectious case, recovered, etc. In addition to S-E-I-R classes, we included a Reported compartment to capture the reporting delay [20] between an individual being exposed to the virus and reported as a case. By customizing the reporting delay and proportion of COVID-19 cases reported, planners can reflect local testing guidelines. We also created a Vaccination compartment to examine the impact of vaccination rollouts [21]. The vaccination component is implemented as a step function where the daily vaccination rate, vaccine efficacy, and the delay for the vaccine to be effective can be modified for different time periods. Table 1 contains a list of key epidemiological parameters and values (full list is provided in Appendix Table A2.2, model equations can be found in Appendix Table A2.3).
Table 1: Key epidemiological parameters
Parameter Definition Value Reference
Latent period, 1/σThe period between the point of infection and the onset of infectiousness (based on 5.1 days incubation period, i.e., from the point of infection to symptoms onset and a 1-day pre-symptomatic infectious period)4.1 daysLauer et al. (2020) [22], He et al. (2020) [23]
Infectious period for asymptomatic cases, 1/ƔAThe period between onset of infectiousness and recovery for someone who is asymptomatic6 daysHu et al. (2020) [24]
Infectious period for mildly symptomatic cases, 1/ƔSMThe period between the onset of infectiousness and self-isolation for someone who develops mild symptoms4 daysLi et al. (2020) [25]
Infectious period for severely symptomatic cases, 1/ƔSSThe period of infectivity for someone who develops severe symptoms4 daysAssumed to be the same as the infectious period for the mild cases
Percentage of asymptomatic cases, PAPercentage of persons who are infected with SARS-CoV-2 but never show symptoms of the disease.33%Oran et al. (2021) [26]

Note: Parameters can be adjusted by the user to reflect local information, if available, as well as the latest scientific evidence.

Note: Parameters can be adjusted by the user to reflect local information, if available, as well as the latest scientific evidence. Disease transmission varies between regions and over the course of the pandemic because of factors such as the initial rate of disease spread, local contact rate, demographics, population density, and public health interventions, among others [27]. The changing COVID-19 transmission is captured in our model with a dynamic effective reproduction number, Reff(t), using a time-varying piecewise function. Reff(t) is estimated in the Tool by fitting the modeled reported cases to the local observed cumulative cases (Figure 2). By creating the timeline of interventions and finding the appropriate model fit, the planner can study the effects of various public health strategies on the changes in Reff(t) and community transmission as shown in the example in the Results section.
Figure 2: Estimated R

Capacity module

The Capacity module estimates the hospital resources required to treat COVID-19 patients. The model is an extension of the Epi module and is split into three compartments representing the hospital environment: Ward accounts for non-critical care inpatient beds; Intensive Care Unit (ICU) represents critical care beds without ventilation; and Ventilator signifies ICU beds with invasive mechanical ventilation (Figure 1). Hospital resource capacity is also included as an input to the model to estimate the potential date when resources may be depleted and to quantify the gap between bed capacity and demand. This module requires users to input locally derived clinical administrative data such as statistics on health care usage and deaths (Table 2), which have changed dramatically across Canadian jurisdictions over the course of the pandemic [29]. The proportion of cases hospitalized and their LOS have changed throughout the pandemic due to the circulation of new variants. Our model allows planners to input multiple sets of health system usage parameter values, making this component highly customizable to each jurisdiction where the timing of changes in health care utilization might differ.
Table 2: Parameter values related to healthcare usage and deaths
Parameter 1st February 2020–31st March 2020 1st April 2020–31st May 2020 1st June 2020–31st July 2020 1st August 2020–30th September 2020 1st October 2020–30th November 2020 1st December 2020–31st January 2021
Percentage of hospitalizations (calibrated), %┴19.011.62.02.73.44.1
Percentage of hospitalizations (baseline), %┴┴11.312.510.53.83.54.0
Percentage of ICU admissions (among hospitalized cases), %°33.922.921.824.332.5┴30.5┴
Percentage of ICU admissions with mechanical ventilation, %°75.764.751.145.133.6┴42.5┴
Average LOS in ward (non-fatal cases), days°22.8623.0714.2712.6612.66*12.66*
Average LOS in ward (fatal cases), days°32.7013.7424.4821.9821.98*21.98*
Average LOS in ICU w/o ventilation (non-fatal cases), days°5.305.006.205.505.50*5.50*
Average LOS in ICU w/o ventilation (fatal cases), days°4.803.405.505.805.80*5.80*
Average LOS in ICU with ventilation (non-fatal cases), days°25.1026.4030.2018.6018.60*18.60*
Average LOS in ICU with ventilation (fatal cases), days°14.0016.9017.7022.1022.10*22.10*
Percentage of deaths among non-critical cases (ward only), %°15.223.410.612.712.7*12.7*
Percentage of deaths among cases admitted to ICU w/o ventilation, %°19.523.916.511.511.5*11.5%*
Percentage of deaths among cases admitted to ICU with ventilation, %°35.546.544.251.751.7*51.7*

Abbreviations: ICU, intensive care unit; LOS, length of stay; w/o, without.

┴These values were calibrated from the Ontario baseline values based on the model best fit (MAPE for cumulative reported cases = 0.8%, MAPE for hospitalizations = 8.5%, MAPE for ICU admissions = 12.8%, MAPE for ICU admissions with ventilation = 18.4%, see also Figure).

┴┴The baseline values for the percentage of cases hospitalized were estimated as the percentage of “total confirmed cases” “ever hospitalized” for the reported period from the daily epidemiologic summaries from Public Health Ontario [28]. Detailed calculations are presented in Appendix Table A2.4. Note that the percentage of cases hospitalized cannot be accurately determined from the existing data as there is no linkage between the testing data and the hospitalization data.

°Based on the detailed information on acute care hospitalizations for patients with a diagnosis of COVID-19 in CIHI’s COVID-19 Hospitalization and Emergency Department Statistics, 2019–2020 and 2020–2021 [29]. Detailed COVID-19 episode of care breakdowns for modelling, by recipient province/territory and admission month, DAD, January to November 2020” Table.

*The values for LOS and fatality rates for the 1st October 2020–30th November 2020 and 1st December 2020–31st January 2021 time periods were assumed to be the same as for the 1st August 2020–30th September 2020 period. While the parameters from the DAD data were available up to 30th November 2020, the last period couldn’t be included in the analysis, as a significant proportion of cases hospitalized from 1st October 2020–30th November 2020 are discharged after 30th November 2020 and will not be included in the reported data.

Abbreviations: ICU, intensive care unit; LOS, length of stay; w/o, without. ┴These values were calibrated from the Ontario baseline values based on the model best fit (MAPE for cumulative reported cases = 0.8%, MAPE for hospitalizations = 8.5%, MAPE for ICU admissions = 12.8%, MAPE for ICU admissions with ventilation = 18.4%, see also Figure). ┴┴The baseline values for the percentage of cases hospitalized were estimated as the percentage of “total confirmed cases” “ever hospitalized” for the reported period from the daily epidemiologic summaries from Public Health Ontario [28]. Detailed calculations are presented in Appendix Table A2.4. Note that the percentage of cases hospitalized cannot be accurately determined from the existing data as there is no linkage between the testing data and the hospitalization data. °Based on the detailed information on acute care hospitalizations for patients with a diagnosis of COVID-19 in CIHI’s COVID-19 Hospitalization and Emergency Department Statistics, 2019–2020 and 2020–2021 [29]. Detailed COVID-19 episode of care breakdowns for modelling, by recipient province/territory and admission month, DAD, January to November 2020” Table. *The values for LOS and fatality rates for the 1st October 2020–30th November 2020 and 1st December 2020–31st January 2021 time periods were assumed to be the same as for the 1st August 2020–30th September 2020 period. While the parameters from the DAD data were available up to 30th November 2020, the last period couldn’t be included in the analysis, as a significant proportion of cases hospitalized from 1st October 2020–30th November 2020 are discharged after 30th November 2020 and will not be included in the reported data.

HCW/PPE module

The HCW/PPE module estimates the number of health care workers (i.e., physicians, nurses and other clinical and hospital support staff) and PPE required to care for COVID-19 patients in inpatient acute-care settings (Figure 1). The formulas to calculate healthcare worker demand are based on the average number of active daily COVID-19 patients in each acute-care setting and information on staff-patient interactions including contact frequency, the number of contacts per patient per shift, shift length, and the staff-to-patient ratio in that setting. PPE usage is calculated for each type of healthcare worker based on the number of each type of equipment required and whether this is per shift (as in the case of eye protection or gowns) or per patient contact (as in the case of disposable gloves) [30]. The default values for PPE usage were obtained from the World Health Organization [31] and from interviews with clinicians in Ontario and Newfoundland (see Appendix Tables A2.5 and A2.6 for default values). Users can alter these values to reflect the reality of their jurisdiction or organization.

Model validation

We validated the Tool results against two benchmarks. First, an internal validation was done to ensure that outputs produced by the model aligned with historical case, hospitalization, ICU admissions, and ICU admissions with ventilation data (Figure 2 and Figure 3, more details can be found in Appendix Tables A3.3.1 and A3.3.2). Second, we compared outputs from the model with case and hospitalization estimates generated by other major models (the McMaster Pandemic model [31], the online Epidemic Calculator [32], University of Pennsylvania’s CHIME PPE Calculator Excel application [33], and COVID-19 Modeling Collaborative’s PPE Resource estimator [34]) and obtained very similar outputs, with no statistical differences across the models (see Appendix A3 for details).
Figure 3: Scenario-based projections in Ontario, Canada (A) Daily number of reported COVID-19 cases (B) Hospitalized cases (C) Patients in ICU (D) Patients in ICU with ventilation. The model was fitted and calibrated (solid black line) to the historical data (teal circles) from 1
For quality assurance of the Excel implementation, formulas and results were verified with a Python version of the model. In the Tool, model fit is evaluated by the root mean square error (RMSE) [35]. The dynamic effective reproduction number (described below) values that minimize RMSE are obtained by utilizing Excel’s Solver add-in [36] with nonlinear optimization using the Generalized Reduced Gradient method [37]. In this paper, we report the Median Absolute Percentage Error (MAPE), which, despite some limitations, is scale-independent and a more easily interpretable measure of the prediction accuracy of a projection [38, 39].

Results

For illustrative examples presented in this section, we use publicly available data for Ontario, Canada on daily cumulative cases [40], daily [40], and cumulative hospitalizations [28], ICU cases, ICU cases with mechanical ventilations [40], and population estimates [41]. For the dates of public health measures, we utilized the COVID-19 Intervention Scan Tool [42] and public announcements. Healthcare usage data were obtained from recent COVID-19 hospitalization statistics published by the Canadian Institute for Health Information [29]. In our first example, we used Ontario data from 1st February 2020 to 31st January 2021 to analyse the effects of various intervention policies on the reproduction number. In the second example, we illustrate how this Tool can be used to build scenarios to project the potential demand for hospital, HCW, and PPE resources using historically available data.

Observed impact of public health interventions

We created a timeline of major public health measures implemented in Ontario from 1st February 2020 to 31st January 2021 (Figure 2(B) and Appendix Table A2.7). We then estimated changes in Reff(t) for this period by fitting our model to the reported cumulative cases. We also validated these estimates by comparing them with the Reff(t) reported by Ontario (See Appendix Figure A3.4). The number of reported cases in Ontario grew from 2 cases on 1st February 2020 to 268,211 cases on 31st January 2021. During the same period, Reff(t) fluctuated, as shown in the top panel of Figure 2. At the beginning of the pandemic when no preventative measures were in place, Reff(t) was estimated to be 2.8. It started to decline to ~0.8 after various escalation measures were implemented including a declaration of a state of emergency, school and business closures, social distancing rules. The re-opening in May 2020 and the lifting of restrictions seemed to be associated with a slow growth of the reproduction number (and therefore transmission), which reached a value of 1.4 in September 2020. The recommendation of wearing face masks announced on 20th May, 2020 [43] seemed to have been associated with a reduction in the Reff. New restrictions were implemented in some regions at the beginning of October 2020 to slow transmission, resulting in Reff that fluctuated around 1 in October-November 2020. In December 2020, the Reff increased again to about 1.3, which coincided with increased social interaction before and during the Christmas holidays. Following a second province-wide lockdown and stay-at-home orders, transmission decreased, and Reff was estimated to be 0.7 at the end of January 2021.

Projected COVID-19 patterns and need for hospital resources

In our second example, we created three scenarios to project demand for healthcare resources for a three-month period, from 1st February 2021 to 30th April 2021 (Table 3, Figure 3) based on historical data presented in the previous example and reopening plans announced in February by the Ontario government [44]. The Tool can be applied in a similar manner to build projections for upcoming months with more recent historical data and current public health measures.
Table 3: Projection scenarios
Scenario 1 Scenario 2 Scenario 3
Potential changes in Reff(t)
Public health announcements Date (2021) Reff(t) Reff(t) Reff(t)
3 regions to reopen [44]10th February0.91.01.1
Additional 27 regions to reopen [53]16th February0.951.11.2
Additional 3 regions to reopen [54]8th March1.01.11.3
Further lifting of restrictions [55]21st March1.051.21.4
Potential further lifting of restrictions1st April1.11.21.5
Potential changes in hospital usage parameters
Percentage of cases requiring hospitalization, %1st February–30th April4.155
Percentage admitted to ICU among those hospitalized, %1st February 1–30th April30.532.534.5
Percentage of ICU admissions with mechanical ventilation, %1st February–30th April42.544.546.5
Potential vaccine rollouts [56]
Daily vaccination rate*January2,2002,2002,200
Daily vaccination rate*February6,9006,9006,900
Daily vaccination rate**March45,00045,00045,000
Daily vaccination rate**April90,00090,00090,000
Capacity available for patients with COVID-19
Hospital beds1st February–30th April4,5144,5144,514
ICU beds1st February–30th April514514514
Additional 500 “surge beds”February1,0141,0141,014
ICU beds with ventilator1st February–30th April328328328

*Number of daily fully vaccinated individuals (i.e., 2 doses with 95% efficacy after 12 days)

**Number of daily vaccinated individuals with a single dose (i.e., 1 dose with 70% efficacy after 12 days)

*Number of daily fully vaccinated individuals (i.e., 2 doses with 95% efficacy after 12 days) **Number of daily vaccinated individuals with a single dose (i.e., 1 dose with 70% efficacy after 12 days) When building our scenarios, we focused on adjusting five parameters: Reff(t), which reflects changes in contact rate and viral transmissibility; hospitalization, ICU and ventilation rates, which vary depending on the virulence of circulating VOCs; and the daily vaccination rate, which changes over time and impacts the proportion of the population susceptible to infection and therefore the epidemic curve. We proposed three scenarios. First, we projected the expected outcomes in a situation where the announced measures of reopening lead to a slight increase in population mobility and person-to-person contact. As a result, in this most optimistic scenario, Scenario 1, Reff(t) was assumed to increase very slightly. In contrast, the two more plausible scenarios represent situations where Reff(t) is assumed to increase by a magnitude like that during the reopening phase of the second wave of the pandemic in Ontario (Scenario 2) or even faster (Scenario 3) due to the higher transmissibility of emerging VOCs [45, 46]. When limited information about emerging VOCs exists, we can only make assumptions on how contagious or virulent they are in comparison with the dominant variant. Since there was early evidence of the Alpha variant (B1.1.7 VOC) being more transmissible and causing more severe illness than earlier variants, we assumed higher transmissibility, hospitalization, ICU and ventilation rates [47, 48] in Scenarios 2 and 3. For all scenarios, the vaccination rates for January to February 2021 represent the number of fully vaccinated individuals in Ontario [49] with 95% efficacy [21]. For the period of March to April 2021, we assumed that only a single dose vaccine was administered with 70% efficacy [49]. This is reflective of the changes in Canada’s national vaccination strategy in Spring 2021, which aimed to maximize single dose immunizations and extend the interval for the second dose by up to four months [49]. Our worst case, Scenario 3, projected almost nine times the number of daily cases projected by Scenario 1 (5,997 vs. 690 on 1st May 2021). In Scenario 3, the projected ICU bed and ventilator demand surpassed the numbers that were available for COVID patients (Tables 3 and 4). However, the additional 500 ICU beds announced by the Ontario Government on 19th January 2021 [50] could provide adequate resources to care for this potential increase in hospitalized cases. As highlighted in Tables 5 and 6, estimated demand for PPE and health care staffing needs were also significantly higher for Scenario 3.
Table 4: Healthcare usage projections
Projected values for 1st May 2021 Scenario 1 Scenario 2 Scenario 3
Daily reported cases6901,7645,997
Hospitalized cases3791,0462,963
In ICU105307930
In ICU with ventilator78223650

Abbreviations: ICU, intensive care unit.

Table 5: Estimated weekly PPE usage
Week end date COVID-19 patients hospitalized Gloves (pair) Eye protection Surgical masks N95 masks Gowns
Scenario 1 3 1 3 1 3 1 3 1 3 1 3
3/07/202158881544,66063,4418,77712,5765,6997,5446,84010,5788,77712,576
3/14/202152585339,86866,5417,83613,1885,0747,8756,12211,1357,83613,188
3/21/202147692836,19872,5547,11114,3654,6058,5735,55412,1317,11114,365
3/28/20214401,05033,46782,0836,57016,2344,2639,7035,12013,6866,57016,234
4/04/20214141,22631,52695,9376,18218,9514,02311,3524,80315,9426,18218,951
4/11/20213981,47430,291115,4115,93422,7743,87513,6714,59119,1155,93422,774
4/18/20213911,82129,728142,6635,81628,1263,81316,9184,48123,5625,81628,126
4/25/20213902,27029,609177,7495,78735,0303,80921,1154,43829,2875,78735,030
5/02/20213912,80229,725219,1635,80543,1923,83526,0884,43336,0475,80543,192
Table 6: Estimated COVID-19 monthly patient staff requirements
Month COVID-19 patients Nurses (Ward) Nurses (ICU) Physicians (Ward) Physicians (ICU) Respiratory therapists Cleaners Porters
Scenario 1 3 1 3 1 3 1 3 1 3 1 3 1 3 1 3
2021–02891961216226490566434549491124427934
2021–03499936119213285597244328281214128226
2021–043951,922954382221,2131988222204105547214
Abbreviations: ICU, intensive care unit. We then compared our projected scenarios with the cases and hospitalizations observed from February to April in Ontario (Figure 3, orange dots). As shown in our worst-case projections (Scenario 3), without enhanced public health measures and with several Ontario hospitals already at or over capacity in February [50], the rise in COVID hospitalizations reached the ICU bed capacity in April 2021 [51, 52]. As illustrated by this example, the scenario comparison can be a useful tool to help policy makers estimate risks and take actions to reduce new infections and ultimately, hospitalizations and fatalities.

Discussion

We developed a tool that can assist various levels of health care planners in making short- and long-term decisions about healthcare capacity, PPE, and healthcare workforce needs. Used alongside other models and information (e.g., financial, ethical, etc.) it could aid planners when weighing decisions related to COVID-19. Different jurisdictions and regions experience differences in intensity and timing of outbreaks [57], presence of VOCs [58] and severity of cases [29], implementation of public health measures [42] and vaccination strategies [59]. These local specifics can be simulated by our Tool with its highly customizable parameters that rely on local data inputs. Our examples from Ontario, Canada illustrate how a planner could apply the Tool to a particular context given the current state of events, local case, hospital, healthcare workforce, supply chain data, and evolving information about emerging VOCs. The coronavirus changes very rapidly due to the high number of mutations [60]. As we witnessed with the current VOC, Omicron, viral transmissibility and disease severity can drastically change from one variant to the next [61]. These factors can be reflected by adjusting parameters in the Tool, making it highly adaptable to new VOCs. Many local [5, 62–67] and national [7, 9, 68, 69] Canadian models and tools [11, 12, 70, 71] were developed to assist jurisdictional authorities and hospital planners with pandemic preparedness. Often these models require a high level of understanding of the underlying mathematical modelling techniques, proficiency in a specific software program and a team of modellers to build projections, maintain and update the model [6, 10–12]. In contrast, existing online tools [70, 71] are relatively simple to use but cannot easily reflect the rapidly changing situation due to the use of static parameters and cannot fit the model to the observed data. Our Tool was designed with our end-users in mind; the Excel implementation, user-friendly outputs, and visualizations make the Tool easy to apply by planners with different levels of knowledge. It also includes several time-varying parameters such as Reff(t), which enables the simulation of multiple waves, and hospital usage parameters, which changed significantly over time. We also periodically update the Tool and parameters with the most recent information and user feedback. The impact of the Tool has been significant. Federal and provincial public health agencies and health ministries, public health units, academics, and hospitals across the country have used it for a variety of purposes including updates to executive teams and government officials, validation of projections produced by other models, and within local dashboards for operational planning. The Government of Newfoundland and Labrador [72] and Toronto Public Health [73] have used the Tool to generate scenarios used in public releases and highlight the importance of public health measures to curb viral transmission. Our Tool continues to evolve and inform health care planning. We continue to engage stakeholders in methodological and policy discussions to understand their health resource planning and pandemic preparedness needs and help them apply the Tool to create realistic local scenarios.

Limitations

Our model, as with any deterministic SEIR-type model, has several limitations [74]. The main assumption of the model, a homogeneous well-mixed population, ignores the fact that most contacts with COVID-19 cases occur not at random but within groups of people in social or geographical proximity [75]. The model works well when simulating outbreaks in large, well-mixed populations rather than in small populations (e.g., small town or long-term care facility), where stochastic effects are much more profound and agent-based type models are more suitable [76]. Our model does not account for differences in susceptibility to COVID-19 with respect to age, comorbidities, and sociodemographic factors [77]. One of the implications is that vaccinating priority populations [78] could not be addressed. We also assumed that vaccinated and recovered individuals develop immunity and are not susceptible to re-infection, which may not be the case [51, 79]. We want to emphasize that this scenario-based Tool does not forecast a future but projects a range of outcomes based on the observed data and model assumptions. These projections are best considered as helpful guides, not definitive outcomes.

Conclusions

Our interactive Tool can help local governments and hospital managers plan their response to the evolving pandemic. The Tool also creates educational value for the healthcare community and can be an important addition to planners’ arsenal of models. Our Tool continues to evolve to reflect our changing understanding of SARS-CoV-2 transmission and its impact on hospital resources, and answer critical questions posed by health system planners. The main difference between this Tool and other existing tools is its ease of use, ability to build scenarios, and ability to provide immediate outcomes that are ready to share with executive decision-makers to help them understand the evolution of the disease and make appropriate decisions. The Tool is readily adaptable to future emerging infectious diseases and can therefore be an important addition to planners’ arsenal of models for the future. The COVID-19 Health System Capacity Planning Tool is currently available by request from CIHI (help@cihi.ca).
  29 in total

1.  COVID-19 in Canada: Experience and Response.

Authors:  Allan S Detsky; Isaac I Bogoch
Journal:  JAMA       Date:  2020-08-25       Impact factor: 56.272

2.  The SEIRS model for infectious disease dynamics.

Authors:  Ottar N Bjørnstad; Katriona Shea; Martin Krzywinski; Naomi Altman
Journal:  Nat Methods       Date:  2020-06       Impact factor: 28.547

3.  Estimation of COVID-19-induced depletion of hospital resources in Ontario, Canada.

Authors:  Kali Barrett; Yasin A Khan; Stephen Mac; Raphael Ximenes; David M J Naimark; Beate Sander
Journal:  CMAJ       Date:  2020-05-14       Impact factor: 8.262

4.  Mathematical modelling of COVID-19 transmission and mitigation strategies in the population of Ontario, Canada.

Authors:  Ashleigh R Tuite; David N Fisman; Amy L Greer
Journal:  CMAJ       Date:  2020-04-08       Impact factor: 8.262

5.  Complexity of the Basic Reproduction Number (R0).

Authors:  Paul L Delamater; Erica J Street; Timothy F Leslie; Y Tony Yang; Kathryn H Jacobsen
Journal:  Emerg Infect Dis       Date:  2019-01       Impact factor: 6.883

Review 6.  Will SARS-CoV-2 Infection Elicit Long-Lasting Protective or Sterilising Immunity? Implications for Vaccine Strategies (2020).

Authors:  David S Kim; Sarah Rowland-Jones; Ester Gea-Mallorquí
Journal:  Front Immunol       Date:  2020-12-09       Impact factor: 7.561

7.  Epidemiological model for the inhomogeneous spatial spreading of COVID-19 and other diseases.

Authors:  Yoav Tsori; Rony Granek
Journal:  PLoS One       Date:  2021-02-19       Impact factor: 3.240

8.  Model-based forecasting for Canadian COVID-19 data.

Authors:  Li-Pang Chen; Qihuang Zhang; Grace Y Yi; Wenqing He
Journal:  PLoS One       Date:  2021-01-19       Impact factor: 3.240

9.  Early transmissibility assessment of the N501Y mutant strains of SARS-CoV-2 in the United Kingdom, October to November 2020.

Authors:  Kathy Leung; Marcus Hh Shum; Gabriel M Leung; Tommy Ty Lam; Joseph T Wu
Journal:  Euro Surveill       Date:  2021-01

10.  Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV-2).

Authors:  Ruiyun Li; Sen Pei; Bin Chen; Yimeng Song; Tao Zhang; Wan Yang; Jeffrey Shaman
Journal:  Science       Date:  2020-03-16       Impact factor: 47.728

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.