| Literature DB >> 35516164 |
Olga Krylova1, Omar Kazmi1, Hui Wang1, Kelvin Lam1, Chloe Logar-Henderson1, Katerina Gapanenko1.
Abstract
Introduction: The COVID-19 pandemic revealed an urgent need for analytic tools to help health system leaders plan for surges in hospital capacity. Our objective was to develop a practical and locally informed Tool to help explore the effects of public health interventions on SARS-CoV-2 transmission and create scenarios to project potential surges in hospital admissions and resource demand.Entities:
Keywords: COVID-19; PPE demand; epidemiology; health policy; health system capacity; hospital bed demand; infectious diseases; interactive tool; predictive modeling; public health; statistics and research methods
Mesh:
Year: 2022 PMID: 35516164 PMCID: PMC9052960 DOI: 10.23889/ijpds.v5i4.1710
Source DB: PubMed Journal: Int J Popul Data Sci ISSN: 2399-4908
Figure 1: Flowchart for the |
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| Latent period, 1/σ | The period between the point of infection and the onset of infectiousness (based on 5.1 days incubation period, i.e., from the point of infection to symptoms onset and a 1-day pre-symptomatic infectious period) | 4.1 days | Lauer et al. (2020) [ |
| Infectious period for asymptomatic cases, 1/ƔA | The period between onset of infectiousness and recovery for someone who is asymptomatic | 6 days | Hu et al. (2020) [ |
| Infectious period for mildly symptomatic cases, 1/ƔSM | The period between the onset of infectiousness and self-isolation for someone who develops mild symptoms | 4 days | Li et al. (2020) [ |
| Infectious period for severely symptomatic cases, 1/ƔSS | The period of infectivity for someone who develops severe symptoms | 4 days | Assumed to be the same as the infectious period for the mild cases |
| Percentage of asymptomatic cases, PA | Percentage of persons who are infected with SARS-CoV-2 but never show symptoms of the disease. | 33% | Oran et al. (2021) [ |
Note: Parameters can be adjusted by the user to reflect local information, if available, as well as the latest scientific evidence.
Figure 2: Estimated R|
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| Percentage of hospitalizations (calibrated), %┴ | 19.0 | 11.6 | 2.0 | 2.7 | 3.4 | 4.1 |
| Percentage of hospitalizations (baseline), %┴┴ | 11.3 | 12.5 | 10.5 | 3.8 | 3.5 | 4.0 |
| Percentage of ICU admissions (among hospitalized cases), %° | 33.9 | 22.9 | 21.8 | 24.3 | 32.5┴ | 30.5┴ |
| Percentage of ICU admissions with mechanical ventilation, %° | 75.7 | 64.7 | 51.1 | 45.1 | 33.6┴ | 42.5┴ |
| Average LOS in ward (non-fatal cases), days° | 22.86 | 23.07 | 14.27 | 12.66 | 12.66* | 12.66* |
| Average LOS in ward (fatal cases), days° | 32.70 | 13.74 | 24.48 | 21.98 | 21.98* | 21.98* |
| Average LOS in ICU w/o ventilation (non-fatal cases), days° | 5.30 | 5.00 | 6.20 | 5.50 | 5.50* | 5.50* |
| Average LOS in ICU w/o ventilation (fatal cases), days° | 4.80 | 3.40 | 5.50 | 5.80 | 5.80* | 5.80* |
| Average LOS in ICU with ventilation (non-fatal cases), days° | 25.10 | 26.40 | 30.20 | 18.60 | 18.60* | 18.60* |
| Average LOS in ICU with ventilation (fatal cases), days° | 14.00 | 16.90 | 17.70 | 22.10 | 22.10* | 22.10* |
| Percentage of deaths among non-critical cases (ward only), %° | 15.2 | 23.4 | 10.6 | 12.7 | 12.7* | 12.7* |
| Percentage of deaths among cases admitted to ICU w/o ventilation, %° | 19.5 | 23.9 | 16.5 | 11.5 | 11.5* | 11.5%* |
| Percentage of deaths among cases admitted to ICU with ventilation, %° | 35.5 | 46.5 | 44.2 | 51.7 | 51.7* | 51.7* |
Abbreviations: ICU, intensive care unit; LOS, length of stay; w/o, without.
┴These values were calibrated from the Ontario baseline values based on the model best fit (MAPE for cumulative reported cases = 0.8%, MAPE for hospitalizations = 8.5%, MAPE for ICU admissions = 12.8%, MAPE for ICU admissions with ventilation = 18.4%, see also Figure).
┴┴The baseline values for the percentage of cases hospitalized were estimated as the percentage of “total confirmed cases” “ever hospitalized” for the reported period from the daily epidemiologic summaries from Public Health Ontario [28]. Detailed calculations are presented in Appendix Table A2.4. Note that the percentage of cases hospitalized cannot be accurately determined from the existing data as there is no linkage between the testing data and the hospitalization data.
°Based on the detailed information on acute care hospitalizations for patients with a diagnosis of COVID-19 in CIHI’s COVID-19 Hospitalization and Emergency Department Statistics, 2019–2020 and 2020–2021 [29]. Detailed COVID-19 episode of care breakdowns for modelling, by recipient province/territory and admission month, DAD, January to November 2020” Table.
*The values for LOS and fatality rates for the 1st October 2020–30th November 2020 and 1st December 2020–31st January 2021 time periods were assumed to be the same as for the 1st August 2020–30th September 2020 period. While the parameters from the DAD data were available up to 30th November 2020, the last period couldn’t be included in the analysis, as a significant proportion of cases hospitalized from 1st October 2020–30th November 2020 are discharged after 30th November 2020 and will not be included in the reported data.
Figure 3: Scenario-based projections in Ontario, Canada (A) Daily number of reported COVID-19 cases (B) Hospitalized cases (C) Patients in ICU (D) Patients in ICU with ventilation. The model was fitted and calibrated (solid black line) to the historical data (teal circles) from 1|
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| 3 regions to reopen [ | 10th February | 0.9 | 1.0 | 1.1 |
| Additional 27 regions to reopen [ | 16th February | 0.95 | 1.1 | 1.2 |
| Additional 3 regions to reopen [ | 8th March | 1.0 | 1.1 | 1.3 |
| Further lifting of restrictions [ | 21st March | 1.05 | 1.2 | 1.4 |
| Potential further lifting of restrictions | 1st April | 1.1 | 1.2 | 1.5 |
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| Percentage of cases requiring hospitalization, % | 1st February–30th April | 4.1 | 5 | 5 |
| Percentage admitted to ICU among those hospitalized, % | 1st February 1–30th April | 30.5 | 32.5 | 34.5 |
| Percentage of ICU admissions with mechanical ventilation, % | 1st February–30th April | 42.5 | 44.5 | 46.5 |
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| Daily vaccination rate* | January | 2,200 | 2,200 | 2,200 |
| Daily vaccination rate* | February | 6,900 | 6,900 | 6,900 |
| Daily vaccination rate** | March | 45,000 | 45,000 | 45,000 |
| Daily vaccination rate** | April | 90,000 | 90,000 | 90,000 |
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| Hospital beds | 1st February–30th April | 4,514 | 4,514 | 4,514 |
| ICU beds | 1st February–30th April | 514 | 514 | 514 |
| Additional 500 “surge beds” | February | 1,014 | 1,014 | 1,014 |
| ICU beds with ventilator | 1st February–30th April | 328 | 328 | 328 |
*Number of daily fully vaccinated individuals (i.e., 2 doses with 95% efficacy after 12 days)
**Number of daily vaccinated individuals with a single dose (i.e., 1 dose with 70% efficacy after 12 days)
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| Daily reported cases | 690 | 1,764 | 5,997 |
| Hospitalized cases | 379 | 1,046 | 2,963 |
| In ICU | 105 | 307 | 930 |
| In ICU with ventilator | 78 | 223 | 650 |
Abbreviations: ICU, intensive care unit.
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| 3/07/2021 | 588 | 815 | 44,660 | 63,441 | 8,777 | 12,576 | 5,699 | 7,544 | 6,840 | 10,578 | 8,777 | 12,576 |
| 3/14/2021 | 525 | 853 | 39,868 | 66,541 | 7,836 | 13,188 | 5,074 | 7,875 | 6,122 | 11,135 | 7,836 | 13,188 |
| 3/21/2021 | 476 | 928 | 36,198 | 72,554 | 7,111 | 14,365 | 4,605 | 8,573 | 5,554 | 12,131 | 7,111 | 14,365 |
| 3/28/2021 | 440 | 1,050 | 33,467 | 82,083 | 6,570 | 16,234 | 4,263 | 9,703 | 5,120 | 13,686 | 6,570 | 16,234 |
| 4/04/2021 | 414 | 1,226 | 31,526 | 95,937 | 6,182 | 18,951 | 4,023 | 11,352 | 4,803 | 15,942 | 6,182 | 18,951 |
| 4/11/2021 | 398 | 1,474 | 30,291 | 115,411 | 5,934 | 22,774 | 3,875 | 13,671 | 4,591 | 19,115 | 5,934 | 22,774 |
| 4/18/2021 | 391 | 1,821 | 29,728 | 142,663 | 5,816 | 28,126 | 3,813 | 16,918 | 4,481 | 23,562 | 5,816 | 28,126 |
| 4/25/2021 | 390 | 2,270 | 29,609 | 177,749 | 5,787 | 35,030 | 3,809 | 21,115 | 4,438 | 29,287 | 5,787 | 35,030 |
| 5/02/2021 | 391 | 2,802 | 29,725 | 219,163 | 5,805 | 43,192 | 3,835 | 26,088 | 4,433 | 36,047 | 5,805 | 43,192 |
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| 2021–02 | 891 | 961 | 216 | 226 | 490 | 566 | 43 | 45 | 49 | 49 | 1 | 1 | 244 | 279 | 3 | 4 |
| 2021–03 | 499 | 936 | 119 | 213 | 285 | 597 | 24 | 43 | 28 | 28 | 1 | 2 | 141 | 282 | 2 | 6 |
| 2021–04 | 395 | 1,922 | 95 | 438 | 222 | 1,213 | 19 | 88 | 22 | 22 | 0 | 4 | 105 | 547 | 2 | 14 |