Literature DB >> 33413740

Early transmissibility assessment of the N501Y mutant strains of SARS-CoV-2 in the United Kingdom, October to November 2020.

Kathy Leung1,2, Marcus Hh Shum3,4,1,2, Gabriel M Leung1,2, Tommy Ty Lam1,3,2,4, Joseph T Wu1,2.   

Abstract

Two new SARS-CoV-2 lineages with the N501Y mutation in the receptor-binding domain of the spike protein spread rapidly in the United Kingdom. We estimated that the earlier 501Y lineage without amino acid deletion Δ69/Δ70, circulating mainly between early September and mid-November, was 10% (6-13%) more transmissible than the 501N lineage, and the 501Y lineage with amino acid deletion Δ69/Δ70, circulating since late September, was 75% (70-80%) more transmissible than the 501N lineage.

Entities:  

Keywords:  20B/501Y.V1; COVID-19; N501Y; SARS-CoV-2; United Kingdom; VOC-202012/01; fitness; lineage B.1.1.7; spike protein; transmissibility

Mesh：

Substances：

Year:  2021        PMID： 33413740      PMCID： PMC7791602          DOI： 10.2807/1560-7917.ES.2020.26.1.2002106

Source DB:  PubMed          Journal:  Euro Surveill        ISSN： 1025-496X


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