Ultrasound Scattering in Cortical Bone.

Recent advances in imaging of bone microstructure have led to a growing recognition of the role of cortical microstructure in osteoporosis. It is now accepted that the assessment of the microstructure of cortical porosity is essential to assess bone mechanical competence and predict fracture risk. Cortical porosity affects the propagation of ultrasound waves because pores act as ultrasound scatterers. Scattering by the porosity is an opportunity that should be leveraged to extract quantitative information about cortical microstructure. Scattering by the pores affects a number of ultrasound parameters that should be quantified, including attenuation, backscatter coefficient, ultrasound diffusivity, and their frequency dependence. Measuring these ultrasound parameters and developing models that describe their dependence upon parameters of cortical microstructure is the key to solve inverse problems that will allow the quantitative assessment of cortical porosity and ultimately will improve the non-invasive ultrasound-based evaluation of bone mechanical competence and fracture risk. In this chapter, we present recent advances in measuring and modeling those parameters in cortical bone.