| Literature DB >> 35501380 |
Xing Cai1,2, Hailan Liu1, Bing Feng3, Meng Yu1, Yang He1, Hesong Liu1, Chen Liang1, Yongjie Yang1, Longlong Tu1, Nan Zhang1, Lina Wang1, Na Yin1, Junying Han1, Zili Yan1, Chunmei Wang1, Pingwen Xu1,4, Qi Wu1, Qingchun Tong5, Yanlin He6,7, Yong Xu8,9.
Abstract
Midbrain dopamine (DA) and serotonin (5-HT) neurons regulate motivated behaviors, including feeding, but less is known about how these circuits may interact. In this study, we found that DA neurons in the mouse ventral tegmental area bidirectionally regulate the activity of 5-HT neurons in the dorsal raphe nucleus (DRN), with weaker stimulation causing DRD2-dependent inhibition and overeating, while stronger stimulation causing DRD1-dependent activation and anorexia. Furthermore, in the activity-based anorexia (ABA) paradigm, which is a mouse model mimicking some clinical features of human anorexia nervosa (AN), we observed a DRD2 to DRD1 shift of DA neurotransmission on 5-HTDRN neurons, which causes constant activation of these neurons and contributes to AN-like behaviors. Finally, we found that systemic administration of a DRD1 antagonist can prevent anorexia and weight loss in ABA. Our results revealed regulation of feeding behavior by stimulation strength-dependent interactions between DA and 5-HT neurons, which may contribute to the pathophysiology of AN.Entities:
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Year: 2022 PMID： 35501380 DOI： 10.1038/s41593-022-01062-0
Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 28.771