Literature DB >> 354933

Evidence for catabolite degradation in the glucose-dependent inactivation of yeast cytoplasmic malate dehydrogenase.

J Neeff, E Hägele, J Nauhaus, U Heer, D Mecke.   

Abstract

The cytoplasmic malate dehydrogenase of Saccharomyces cerevisiae was radioactively labeled during its synthesis on a glucose-free derepression medium. After purification a sensitive radio-immunoassay for this enzyme could be developed. The assay showed that after the physiological, glucose-dependent 'catabolite inactivation' of cytoplasmic malate dehydrogenase an inactive enzyme protein is immunologically not detectable. Together with the irreversibility of this reaction in vivo this finding strongly suggest a proteolytic mechanism of enzyme inactivation. For this process the term 'catabolite degradation' is used.

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Year:  1978        PMID： 354933     DOI： 10.1111/j.1432-1033.1978.tb12399.x

Source DB:  PubMed          Journal:  Eur J Biochem        ISSN： 0014-2956


  11 in total

1.  Regulation of Saccharomyces cerevisiae nicotinamide adenine dinucleotide phosphate-dependent glutamate dehydrogenase by proteolysis during carbon starvation.

Authors:  M J Mazón; B A Hemmings
Journal:  J Bacteriol       Date:  1979-08       Impact factor: 3.490

2.  Calculation of half-lives of proteins in vivo. Heterogeneity in the rate of degradation of yeast proteins.

Authors:  J M Gancedo; S López; F Ballesteros
Journal:  Mol Cell Biochem       Date:  1982-03-19       Impact factor: 3.396

Review 3.  Regulation of trehalose mobilization in fungi.

Authors:  J M Thevelein
Journal:  Microbiol Rev       Date:  1984-03

4.  Regulation of invertase synthesis by glucose in Saccharomyces cerevisiae.

Authors:  S Mormeneo; R Sentandreu
Journal:  J Bacteriol       Date:  1982-10       Impact factor: 3.490

5.  Carboxypeptidase S- and carboxypeptidase Y-deficient mutants of Saccharomyces cerevisiae.

Authors:  D H Wolf; C Ehmann
Journal:  J Bacteriol       Date:  1981-08       Impact factor: 3.490

6.  Molecular events associated with glucose repression of invertase in Saccharomyces cerevisiae.

Authors:  S Mormeneo; R Sentandreu
Journal:  Antonie Van Leeuwenhoek       Date:  1986       Impact factor: 2.271

7.  Characterization of the glucose-induced inactivation of maltose permease in Saccharomyces cerevisiae.

Authors:  I Medintz; H Jiang; E K Han; W Cui; C A Michels
Journal:  J Bacteriol       Date:  1996-04       Impact factor: 3.490

8.  The maltose permease encoded by the MAL61 gene of Saccharomyces cerevisiae exhibits both sequence and structural homology to other sugar transporters.

Authors:  Q Cheng; C A Michels
Journal:  Genetics       Date:  1989-11       Impact factor: 4.562

9.  Degradation and turnover of peroxisomes in the yeast Hansenula polymorpha induced by selective inactivation of peroxisomal enzymes.

Authors:  M Veenhuis; A Douma; W Harder; M Osumi
Journal:  Arch Microbiol       Date:  1983-06       Impact factor: 2.552

10.  Glucose-induced inactivation of mitochondrial enzymes in the yeast Saccharomyces cerevisiae.

Authors:  M Takeda
Journal:  Biochem J       Date:  1981-08-15       Impact factor: 3.857
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