Literature DB >> 35491358

Structure-specific nucleases: role in Okazaki fragment maturation.

Lingzi Ma1, Haitao Sun1, Tharindumala Abeywardana1, Li Zheng2, Binghui Shen3.   

Abstract

Proper function of structure-specific nucleases is key for faithful Okazaki fragment maturation (OFM) process completion. Deregulation of such nucleases leads to aberrant OFM and causes a spectrum of mutations, some of which may confer survival outcomes under specific stresses and serve as attractive targets for therapeutic intervention in human cancers.
Copyright © 2022 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  BRCAness; Okazaki fragment maturation; PARPs; duplication mutation; structure-specific nuclease; template switch

Mesh：

Substances：

Year:  2022        PMID： 35491358      PMCID： PMC9283310          DOI： 10.1016/j.tig.2022.04.001

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.821


  17 in total

1.  Tyrosine phosphorylation controls PCNA function through protein stability.

Authors:  Shao-Chun Wang; Yusuke Nakajima; Yung-Luen Yu; Weiya Xia; Chun-Te Chen; Cheng-Chieh Yang; Eric W McIntush; Long-Yuan Li; David H Hawke; Ryuji Kobayashi; Mien-Chie Hung
Journal:  Nat Cell Biol       Date:  2006-11-19       Impact factor: 28.824

2.  Daughter-strand gaps in DNA replication - substrates of lesion processing and initiators of distress signalling.

Authors:  Ronald P Wong; Kirill Petriukov; Helle D Ulrich
Journal:  DNA Repair (Amst)       Date:  2021-06-23

3.  Multi-invasions Are Recombination Byproducts that Induce Chromosomal Rearrangements.

Authors:  Aurèle Piazza; William Douglass Wright; Wolf-Dietrich Heyer
Journal:  Cell       Date:  2017-08-03       Impact factor: 41.582

4.  A novel mutation avoidance mechanism dependent on S. cerevisiae RAD27 is distinct from DNA mismatch repair.

Authors:  D X Tishkoff; N Filosi; G M Gaida; R D Kolodner
Journal:  Cell       Date:  1997-01-24       Impact factor: 41.582

Review 5.  Eukaryotic DNA Replication Fork.

Authors:  Peter M J Burgers; Thomas A Kunkel
Journal:  Annu Rev Biochem       Date:  2017-03-01       Impact factor: 23.643

6.  G4 resolvase 1 binds both DNA and RNA tetramolecular quadruplex with high affinity and is the major source of tetramolecular quadruplex G4-DNA and G4-RNA resolving activity in HeLa cell lysates.

Authors:  Steven D Creacy; Eric D Routh; Fumiko Iwamoto; Yoshikuni Nagamine; Steven A Akman; James P Vaughn
Journal:  J Biol Chem       Date:  2008-10-07       Impact factor: 5.157

7.  Sequential switching of binding partners on PCNA during in vitro Okazaki fragment maturation.

Authors:  Daniel Dovrat; Joseph L Stodola; Peter M J Burgers; Amir Aharoni
Journal:  Proc Natl Acad Sci U S A       Date:  2014-09-16       Impact factor: 11.205

8.  The Importance of Poly(ADP-Ribose) Polymerase as a Sensor of Unligated Okazaki Fragments during DNA Replication.

Authors:  Hana Hanzlikova; Ilona Kalasova; Annie A Demin; Lewis E Pennicott; Zuzana Cihlarova; Keith W Caldecott
Journal:  Mol Cell       Date:  2018-07-05       Impact factor: 17.970

9.  CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions.

Authors:  Michal Zimmermann; Olga Murina; Martin A M Reijns; Angelo Agathanggelou; Rachel Challis; Žygimantė Tarnauskaitė; Morwenna Muir; Adeline Fluteau; Michael Aregger; Andrea McEwan; Wei Yuan; Matthew Clarke; Maryou B Lambros; Shankara Paneesha; Paul Moss; Megha Chandrashekhar; Stephane Angers; Jason Moffat; Valerie G Brunton; Traver Hart; Johann de Bono; Tatjana Stankovic; Andrew P Jackson; Daniel Durocher
Journal:  Nature       Date:  2018-07-04       Impact factor: 49.962

10.  Ubiquitinated-PCNA protects replication forks from DNA2-mediated degradation by regulating Okazaki fragment maturation and chromatin assembly.

Authors:  Tanay Thakar; Wendy Leung; Claudia M Nicolae; Kristen E Clements; Binghui Shen; Anja-Katrin Bielinsky; George-Lucian Moldovan
Journal:  Nat Commun       Date:  2020-05-01       Impact factor: 14.919
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