Carolyn J Crandall1, Joseph C Larson2, Kristine E Ensrud3, Andrea Z LaCroix4, Katherine A Guthrie5, Susan D Reed6, Shalender Bhasin7, Susan Diem8. 1. Dept. of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA, United States of America. Electronic address: ccrandall@mednet.ucla.edu. 2. Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America. Electronic address: jlarson@WHI.org. 3. Division of Epidemiology and Community Health, Dept. of Medicine, University of Minnesota, Center for Care Delivery and Outcomes Research, Veterans Affairs, Minneapolis, MN, United States of America. Electronic address: ensru001@umn.edu. 4. Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, CA, United States of America. Electronic address: alacroix@health.ucsd.edu. 5. Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America. Electronic address: kguthrie@fredhutch.org. 6. Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, WA, United States of America; Department of Epidemiology, University of Washington School of Medicine, Seattle, WA, United States of America. Electronic address: reeds@uw.edu. 7. Dept. of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, United States of America. Electronic address: sbhasin@bwh.harvard.edu. 8. Minneapolis Veterans Affairs Health Care System, Department of Medicine, University of Minnesota, Minneapolis, MN, United States of America. Electronic address: sdiem@umn.edu.
Abstract
OBJECTIVES: To evaluate whether single measurements of serum estradiol (E2), estrone (E1) and sex hormone-binding globulin (SHBG) concentration distinguishes between women with and without menopausal symptom bother. STUDY DESIGN: We analyzed baseline data from two clinical trials conducted in 2012-2017: MsFLASH 03 (178 peri-/post-menopausal women aged 40-62 years with bothersome vasomotor symptoms, mean age 54) and MsFLASH 05 (181 post-menopausal women aged 45-70 years with moderate-to-severe vulvovaginal symptoms, mean age 61). MAIN OUTCOME MEASURES: Symptom bother (hot flushes or flashes, night sweats, sweating, aching in muscles and joints, change in sexual desire, vaginal dryness during intercourse, and avoiding intimacy) in the past month was assessed using the Menopause-Specific Quality of Life questionnaire. Using logistic regression, we calculated the area under the receiver operating characteristic curve (AUC) values for E1, E2, and SHBG concentration in relation to being at least somewhat bothered (symptom bother score ≥3) by each symptom within each trial study population. RESULTS: AUC values (95% confidence interval) ranged between 0.51 (0.41-0.60) and 0.62 (0.53, 0.72) for MsFLASH 03 and between 0.51 (0.42, 0.59) and 0.64 (0.53, 0.75) for MsFLASH 05. There was little evidence of associations between serum hormone levels and bother by a given menopausal symptom. CONCLUSION: These findings do not support the clinical utility of a single measurement of serum of E1, E2, or SHBG concentrations in differentiating between women who are bothered by a given menopausal symptom and those who are not.
OBJECTIVES: To evaluate whether single measurements of serum estradiol (E2), estrone (E1) and sex hormone-binding globulin (SHBG) concentration distinguishes between women with and without menopausal symptom bother. STUDY DESIGN: We analyzed baseline data from two clinical trials conducted in 2012-2017: MsFLASH 03 (178 peri-/post-menopausal women aged 40-62 years with bothersome vasomotor symptoms, mean age 54) and MsFLASH 05 (181 post-menopausal women aged 45-70 years with moderate-to-severe vulvovaginal symptoms, mean age 61). MAIN OUTCOME MEASURES: Symptom bother (hot flushes or flashes, night sweats, sweating, aching in muscles and joints, change in sexual desire, vaginal dryness during intercourse, and avoiding intimacy) in the past month was assessed using the Menopause-Specific Quality of Life questionnaire. Using logistic regression, we calculated the area under the receiver operating characteristic curve (AUC) values for E1, E2, and SHBG concentration in relation to being at least somewhat bothered (symptom bother score ≥3) by each symptom within each trial study population. RESULTS: AUC values (95% confidence interval) ranged between 0.51 (0.41-0.60) and 0.62 (0.53, 0.72) for MsFLASH 03 and between 0.51 (0.42, 0.59) and 0.64 (0.53, 0.75) for MsFLASH 05. There was little evidence of associations between serum hormone levels and bother by a given menopausal symptom. CONCLUSION: These findings do not support the clinical utility of a single measurement of serum of E1, E2, or SHBG concentrations in differentiating between women who are bothered by a given menopausal symptom and those who are not.
Authors: Ellen B Gold; Alicia Colvin; Nancy Avis; Joyce Bromberger; Gail A Greendale; Lynda Powell; Barbara Sternfeld; Karen Matthews Journal: Am J Public Health Date: 2006-05-30 Impact factor: 9.308
Authors: Lisa Gallicchio; Susan R Miller; Judith Kiefer; Teresa Greene; Howard A Zacur; Jodi A Flaws Journal: Menopause Date: 2015-10 Impact factor: 2.953
Authors: Chrissy Schilling; Lisa Gallicchio; Susan R Miller; Patricia Langenberg; Howard Zacur; Jodi A Flaws Journal: Maturitas Date: 2006-12-21 Impact factor: 4.342
Authors: Kala Visvanathan; Lisa Gallicchio; Chrissy Schilling; Janice K Babus; Lynn M Lewis; Susan R Miller; Howard Zacur; Jodi A Flaws Journal: Obstet Gynecol Date: 2005-12 Impact factor: 7.661
Authors: J R Hilditch; J Lewis; A Peter; B van Maris; A Ross; E Franssen; G H Guyatt; P G Norton; E Dunn Journal: Maturitas Date: 1996-07 Impact factor: 4.342
Authors: Nancy E Avis; Sarah Brockwell; John F Randolph; Shunhua Shen; Virginia S Cain; Marcia Ory; Gail A Greendale Journal: Menopause Date: 2009 May-Jun Impact factor: 2.953
Authors: Susan D Reed; Andrea Z LaCroix; Garnet L Anderson; Kristine E Ensrud; Bette Caan; Janet S Carpenter; Lee Cohen; Susan J Diem; Ellen W Freeman; Hadine Joffe; Joseph C Larson; Susan M McCurry; Caroline M Mitchell; Katherine M Newton; Barbara Sternfeld; Katherine A Guthrie Journal: Menopause Date: 2020-04 Impact factor: 2.953
Authors: Kristine E Ensrud; Joseph C Larson; Katherine A Guthrie; Carolyn J Crandall; Andrea Z LaCroix; Susan D Reed; Shalender Bhasin; Caroline M Mitchell; Hadine Joffe Journal: Menopause Date: 2022-08-16 Impact factor: 3.310