Xuewei Li1,2,3,4,5, Lu Ma1,2,3,4,5, Jie Hu2,3,4,5, Qiong Xu2,3,4,5, Kai Wang6,7,8,9,10, Yan Li1,2,3,4,5, Jia Qu3,11, Mingwei Zhao1,2,3,4,5. 1. Institute of Medical Technology, Peking University Health Science Center, Beijing, China. 2. Department of Ophthalmology & Clinical Centre of Optometry, Peking University People's Hospital, Beijing , 100044, China. 3. College of Optometry, Peking University Health Science Center, Beijing, China. 4. Eye Disease and Optometry Institute, Peking University People's Hospital, Beijing, China. 5. Beijing Key Laboratory of the Diagnosis and Therapy of Retinal and Choroid Diseases, Beijing, China. 6. Institute of Medical Technology, Peking University Health Science Center, Beijing, China. wang_kai@bjmu.edu.cn. 7. Department of Ophthalmology & Clinical Centre of Optometry, Peking University People's Hospital, Beijing , 100044, China. wang_kai@bjmu.edu.cn. 8. College of Optometry, Peking University Health Science Center, Beijing, China. wang_kai@bjmu.edu.cn. 9. Eye Disease and Optometry Institute, Peking University People's Hospital, Beijing, China. wang_kai@bjmu.edu.cn. 10. Beijing Key Laboratory of the Diagnosis and Therapy of Retinal and Choroid Diseases, Beijing, China. wang_kai@bjmu.edu.cn. 11. School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Abstract
AIMS: The present study investigated the difference in choriocapillaris (CC) perfusion between different AL/K ratio groups with similar spherical equivalent refraction (SER) and analyzed factors affecting CC perfusion. METHODS: This cross-sectional study included 129 children with low-to-moderate myopia. Axial length (AL), average K-reading (Ave-K), and SER were measured. Choroidal vascularity, including the total choroidal area (TA), choroidal luminal area (LA), stromal area (SA), choroidal vascularity index (CVI), CC flow voids (FVs), and FVs%, was obtained using optical coherence tomography angiography. RESULTS: Participants with similar SER were divided into two groups (high AL/K ratio, n = 57; low AL/K ratio, n = 72). The high AL/K group had lower LA, TA, and CVI (P < 0.01) and lower FVs (inner ring and fovea, P < 0.05) and FVs% (outer ring, inner ring, and fovea, P < 0.05). The AL/K ratio and FVs% were negatively correlated in the outer ring (r = - 0.174, P < 0.05) and inner ring (r = - 0.174, P < 0.05). The Ave-K and inner FVs (r = 0.178, P < 0.05), outer FVs% (r = 0.175, P < 0.05), and inner FVs% (r = 0.196, P < 0.05) were positively correlated. In stepwise multiple regression for the outer ring, the horizontal CVI was related to FVs (β = 0.175, P < 0.05), and the vertical CVI was related to FVs% (β = 0.232, P < 0.01). Independent risk factors associated with inner FVs area were vertical CVI (β = 0.329; P < 0.001) and SER (β = - 0.196, P < 0.05); FVs% was also associated with vertical CVI (β = 0.360, P < 0.01) and SER (β = - 0.196, P < 0.05). CONCLUSION: With a similar SER, myopic eyes with a higher AL/K ratio maintained more CC perfusion and lower CVI, which may indicate rapid myopic progression. Low K-reading eyes had more CC perfusion and less CVI, which may explain the relatively poor myopia control efficacy in the clinic.
AIMS: The present study investigated the difference in choriocapillaris (CC) perfusion between different AL/K ratio groups with similar spherical equivalent refraction (SER) and analyzed factors affecting CC perfusion. METHODS: This cross-sectional study included 129 children with low-to-moderate myopia. Axial length (AL), average K-reading (Ave-K), and SER were measured. Choroidal vascularity, including the total choroidal area (TA), choroidal luminal area (LA), stromal area (SA), choroidal vascularity index (CVI), CC flow voids (FVs), and FVs%, was obtained using optical coherence tomography angiography. RESULTS: Participants with similar SER were divided into two groups (high AL/K ratio, n = 57; low AL/K ratio, n = 72). The high AL/K group had lower LA, TA, and CVI (P < 0.01) and lower FVs (inner ring and fovea, P < 0.05) and FVs% (outer ring, inner ring, and fovea, P < 0.05). The AL/K ratio and FVs% were negatively correlated in the outer ring (r = - 0.174, P < 0.05) and inner ring (r = - 0.174, P < 0.05). The Ave-K and inner FVs (r = 0.178, P < 0.05), outer FVs% (r = 0.175, P < 0.05), and inner FVs% (r = 0.196, P < 0.05) were positively correlated. In stepwise multiple regression for the outer ring, the horizontal CVI was related to FVs (β = 0.175, P < 0.05), and the vertical CVI was related to FVs% (β = 0.232, P < 0.01). Independent risk factors associated with inner FVs area were vertical CVI (β = 0.329; P < 0.001) and SER (β = - 0.196, P < 0.05); FVs% was also associated with vertical CVI (β = 0.360, P < 0.01) and SER (β = - 0.196, P < 0.05). CONCLUSION: With a similar SER, myopic eyes with a higher AL/K ratio maintained more CC perfusion and lower CVI, which may indicate rapid myopic progression. Low K-reading eyes had more CC perfusion and less CVI, which may explain the relatively poor myopia control efficacy in the clinic.
Authors: Ian G Morgan; Amanda N French; Regan S Ashby; Xinxing Guo; Xiaohu Ding; Mingguang He; Kathryn A Rose Journal: Prog Retin Eye Res Date: 2017-09-23 Impact factor: 21.198