Mengjie Li1, Yingya Zhao1, Qi Dai1, Ginger Milne2, Jirong Long1, Qiuyin Cai1, Qingxia Chen3, Xianglan Zhang4, Qing Lan5, Nathaniel Rothman5, Yu-Tang Gao6, Xiao-Ou Shu1, Wei Zheng1, Gong Yang1. 1. Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee, USA. 2. Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee, USA. 3. Department of Biostatistics, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee, USA. 4. Tennessee Department of Health, Nashville, Tennessee, USA. 5. Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, Bethesda, Maryland, USA. 6. Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Abstract
OBJECTIVE: This study aimed to investigate whether and how lipid peroxidation markers are associated with height and obesity measures. METHODS: In two independent samples of women (Study 1: n = 1,005; Study 2: n = 1,158), systemic levels of lipid peroxidation were assessed by urinary markers F2 -isoprostanes (F2 -IsoPs) and its major metabolite (F2 -IsoP-M), with gas chromatography/negative ion chemical ionization mass spectrometry assays. Anthropometric parameters were directly measured and genetically estimated, and they were used in the primary analysis and in a Mendelian randomization analysis in relation to lipid peroxidation, respectively, with general linear models. RESULTS: After adjusting for potential confounders, it was found that measured adult height was inversely associated with levels of F2 -IsoPs (β = -0.89, p < 0.001) and F2 -IsoP-M (β = -0.71, p = 0.003), whereas obesity measures were positively associated with F2 -IsoP-M (β = 1.81, p < 0.001 for BMI; and β = 0.77, p < 0.001 for waist circumference). Results were consistent between the two study samples. The opposite associations were further replicated when using genetically determined measures of height and obesity in the Mendelian randomization analysis. Moreover, analyses mutually adjusted for height and obesity measures suggested that these associations were independent of one another. CONCLUSIONS: This study, for the first time, to our knowledge, reveals that a shared biological process (lipid peroxidation) is associated with both height and obesity measures but in the opposite direction.
OBJECTIVE: This study aimed to investigate whether and how lipid peroxidation markers are associated with height and obesity measures. METHODS: In two independent samples of women (Study 1: n = 1,005; Study 2: n = 1,158), systemic levels of lipid peroxidation were assessed by urinary markers F2 -isoprostanes (F2 -IsoPs) and its major metabolite (F2 -IsoP-M), with gas chromatography/negative ion chemical ionization mass spectrometry assays. Anthropometric parameters were directly measured and genetically estimated, and they were used in the primary analysis and in a Mendelian randomization analysis in relation to lipid peroxidation, respectively, with general linear models. RESULTS: After adjusting for potential confounders, it was found that measured adult height was inversely associated with levels of F2 -IsoPs (β = -0.89, p < 0.001) and F2 -IsoP-M (β = -0.71, p = 0.003), whereas obesity measures were positively associated with F2 -IsoP-M (β = 1.81, p < 0.001 for BMI; and β = 0.77, p < 0.001 for waist circumference). Results were consistent between the two study samples. The opposite associations were further replicated when using genetically determined measures of height and obesity in the Mendelian randomization analysis. Moreover, analyses mutually adjusted for height and obesity measures suggested that these associations were independent of one another. CONCLUSIONS: This study, for the first time, to our knowledge, reveals that a shared biological process (lipid peroxidation) is associated with both height and obesity measures but in the opposite direction.
Authors: John F Keaney; Martin G Larson; Ramachandran S Vasan; Peter W F Wilson; Izabella Lipinska; Diane Corey; Joseph M Massaro; Patrice Sutherland; Joseph A Vita; Emelia J Benjamin Journal: Arterioscler Thromb Vasc Biol Date: 2003-01-30 Impact factor: 8.311
Authors: Y Ben-Shlomo; J Holly; A McCarthy; P Savage; D Davies; D Gunnell; G Davey Smith Journal: Clin Endocrinol (Oxf) Date: 2003-09 Impact factor: 3.478
Authors: Christopher P Nelson; Stephen E Hamby; Danish Saleheen; Jenna C Hopewell; Lingyao Zeng; Themistocles L Assimes; Stavroula Kanoni; Christina Willenborg; Stephen Burgess; Phillipe Amouyel; Sonia Anand; Stefan Blankenberg; Bernhard O Boehm; Robert J Clarke; Rory Collins; George Dedoussis; Martin Farrall; Paul W Franks; Leif Groop; Alistair S Hall; Anders Hamsten; Christian Hengstenberg; G Kees Hovingh; Erik Ingelsson; Sekar Kathiresan; Frank Kee; Inke R König; Jaspal Kooner; Terho Lehtimäki; Winifred März; Ruth McPherson; Andres Metspalu; Markku S Nieminen; Christopher J O'Donnell; Colin N A Palmer; Annette Peters; Markus Perola; Muredach P Reilly; Samuli Ripatti; Robert Roberts; Veikko Salomaa; Svati H Shah; Stefan Schreiber; Agneta Siegbahn; Unnur Thorsteinsdottir; Giovani Veronesi; Nicholas Wareham; Cristen J Willer; Pierre A Zalloua; Jeanette Erdmann; Panos Deloukas; Hugh Watkins; Heribert Schunkert; John Danesh; John R Thompson; Nilesh J Samani Journal: N Engl J Med Date: 2015-04-08 Impact factor: 91.245
Authors: Yan Guo; Shaneda Warren Andersen; Xiao-Ou Shu; Kyriaki Michailidou; Manjeet K Bolla; Qin Wang; Montserrat Garcia-Closas; Roger L Milne; Marjanka K Schmidt; Jenny Chang-Claude; Allison Dunning; Stig E Bojesen; Habibul Ahsan; Kristiina Aittomäki; Irene L Andrulis; Hoda Anton-Culver; Volker Arndt; Matthias W Beckmann; Alicia Beeghly-Fadiel; Javier Benitez; Natalia V Bogdanova; Bernardo Bonanni; Anne-Lise Børresen-Dale; Judith Brand; Hiltrud Brauch; Hermann Brenner; Thomas Brüning; Barbara Burwinkel; Graham Casey; Georgia Chenevix-Trench; Fergus J Couch; Angela Cox; Simon S Cross; Kamila Czene; Peter Devilee; Thilo Dörk; Martine Dumont; Peter A Fasching; Jonine Figueroa; Dieter Flesch-Janys; Olivia Fletcher; Henrik Flyger; Florentia Fostira; Marilie Gammon; Graham G Giles; Pascal Guénel; Christopher A Haiman; Ute Hamann; Maartje J Hooning; John L Hopper; Anna Jakubowska; Farzana Jasmine; Mark Jenkins; Esther M John; Nichola Johnson; Michael E Jones; Maria Kabisch; Muhammad Kibriya; Julia A Knight; Linetta B Koppert; Veli-Matti Kosma; Vessela Kristensen; Loic Le Marchand; Eunjung Lee; Jingmei Li; Annika Lindblom; Robert Luben; Jan Lubinski; Kathi E Malone; Arto Mannermaa; Sara Margolin; Frederik Marme; Catriona McLean; Hanne Meijers-Heijboer; Alfons Meindl; Susan L Neuhausen; Heli Nevanlinna; Patrick Neven; Janet E Olson; Jose I A Perez; Barbara Perkins; Paolo Peterlongo; Kelly-Anne Phillips; Katri Pylkäs; Anja Rudolph; Regina Santella; Elinor J Sawyer; Rita K Schmutzler; Caroline Seynaeve; Mitul Shah; Martha J Shrubsole; Melissa C Southey; Anthony J Swerdlow; Amanda E Toland; Ian Tomlinson; Diana Torres; Thérèse Truong; Giske Ursin; Rob B Van Der Luijt; Senno Verhoef; Alice S Whittemore; Robert Winqvist; Hui Zhao; Shilin Zhao; Per Hall; Jacques Simard; Peter Kraft; Paul Pharoah; David Hunter; Douglas F Easton; Wei Zheng Journal: PLoS Med Date: 2016-08-23 Impact factor: 11.069