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Literature DB >> 3547086

Activation of c-myc and c-K-ras oncogenes in primary rat tumors induced by ionizing radiation.

M J Sawey, A T Hood, F J Burns, S J Garte.

Abstract

An activated K-ras oncogene was detected by transfection in NIH 3T3 cells and by Southern blot analysis in 6 of 12 rat skin tumors induced by ionizing radiation. The DNA from 10 of the 12 tumors also showed c-myc gene amplification and restriction polymorphisms. Evidence for tissue specificity was observed in patterns of oncogene activation, with each of three clear cell carcinomas exhibiting activation of both c-myc and K-ras oncogenes.

Entities: Disease Gene Species

Mesh：

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Year: 1987 PMID： 3547086 PMCID： PMC365153 DOI： 10.1128/mcb.7.2.932-935.1987

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

34 in total

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17 in total

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