Literature DB >> 3546597

Mutagenic perylenequinone metabolites of Alternaria alternata: altertoxins I, II, and III.

M E Stack, E P Mazzola, S W Page, A E Pohland, R J Highet, M S Tempesta, D G Corley.   

Abstract

The mold genus Alternaria is a widely distributed plant pathogen. Some of these species, e.g., A. alternata, are common decay organisms of fruits and vegetables. Two novel perylene oxide metabolites, altertoxins II and III, have been identified in extracts of A. alternata isolates that exhibit mutagenic responses in the Ames Salmonella typhimurium assay. These identifications were based on mass, optical rotational, and 1H- and 13C-nmr spectral studies. Previous reports of related perylene dione mycotoxins have been clarified.

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Year:  1986        PMID: 3546597     DOI: 10.1021/np50047a017

Source DB:  PubMed          Journal:  J Nat Prod        ISSN: 0163-3864            Impact factor:   4.050


  17 in total

1.  Permeation and metabolism of Alternaria mycotoxins with perylene quinone structure in cultured Caco-2 cells.

Authors:  Stefanie C Fleck; Erika Pfeiffer; Manfred Metzler
Journal:  Mycotoxin Res       Date:  2013-10-31       Impact factor: 3.833

2.  Photodynamic production of superoxide in vitro by altertoxins in the presence of reducing agents.

Authors:  P E Hartman; C K Suzuki; M E Stack
Journal:  Appl Environ Microbiol       Date:  1989-01       Impact factor: 4.792

3.  Altertoxins with potent anti-HIV activity from Alternaria tenuissima QUE1Se, a fungal endophyte of Quercus emoryi.

Authors:  Bharat P Bashyal; Brian P Wellensiek; Rajesh Ramakrishnan; Stanley H Faeth; Nafees Ahmad; A A Leslie Gunatilaka
Journal:  Bioorg Med Chem       Date:  2014-09-08       Impact factor: 3.641

4.  Alternaria toxins in South African sunflower seeds: cooperative study.

Authors:  Sebastian Hickert; Lena Hermes; Lucas Maciel Mauriz Marques; Christine Focke; Benedikt Cramer; Norberto Peporine Lopes; Bradley Flett; Hans-Ulrich Humpf
Journal:  Mycotoxin Res       Date:  2017-07-28       Impact factor: 3.833

5.  Chlorinated Dehydrocurvularins and Alterperylenepoxide A from Alternaria sp. AST0039, a Fungal Endophyte of Astragalus lentiginosus.

Authors:  Bharat P Bashyal; E M Kithsiri Wijeratne; Joseph Tillotson; A Elizabeth Arnold; Eli Chapman; A A Leslie Gunatilaka
Journal:  J Nat Prod       Date:  2017-01-31       Impact factor: 4.050

Review 6.  Elsinoë fawcettii and Elsinoë australis: the fungal pathogens causing citrus scab.

Authors:  Kuang-Ren Chung
Journal:  Mol Plant Pathol       Date:  2010-10-01       Impact factor: 5.663

7.  Survey of Alternaria toxin contamination in food from the German market, using a rapid HPLC-MS/MS approach.

Authors:  Sebastian Hickert; Marian Bergmann; Seyma Ersen; Benedikt Cramer; Hans-Ulrich Humpf
Journal:  Mycotoxin Res       Date:  2015-09-26       Impact factor: 3.833

8.  Photodynamic inhibitory effects of three perylenequinones on human colorectal carcinoma cell line and primate embryonic stem cell line.

Authors:  Lan Ma; Hong Tai; Cong Li; Yu Zhang; Ze-Hua Wang; Wei-Zhi Ji
Journal:  World J Gastroenterol       Date:  2003-03       Impact factor: 5.742

9.  Activation of the Nrf2-ARE pathway by the Alternaria alternata mycotoxins altertoxin I and II.

Authors:  Katharina Jarolim; Giorgia Del Favero; Gudrun Pahlke; Victoria Dostal; Kristin Zimmermann; Elke Heiss; Doris Ellmer; Timo D Stark; Thomas Hofmann; Doris Marko
Journal:  Arch Toxicol       Date:  2016-05-13       Impact factor: 5.153

Review 10.  Potential of small-molecule fungal metabolites in antiviral chemotherapy.

Authors:  Biswajit G Roy
Journal:  Antivir Chem Chemother       Date:  2017-07-23
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