| Literature DB >> 35462960 |
Arianna M Nassiri1, Roy D Pruden2, Cole A Holan3, Angela D Guerra3, Peris W Nganga2, Matthew H Wilkinson1, Karla A Lawson4, Coburn H Allen1, Victoria S Gregg1, Jessica A Naiditch4.
Abstract
Aim: Conduct a time trend analysis that describes 2 groups of patients admitted to a large tertiary children's hospital that presented with appendicitis and determine if there was an increase in complicated appendicitis when compared between 2 time periods before and during the early coronavirus disease 2019 (COVID-19) pandemic of 2020.Entities:
Keywords: COVID‐19; CT scan; appendicitis; complicated appendicitis; pandemic; pediatric emergency medicine; pediatrics
Year: 2022 PMID: 35462960 PMCID: PMC9019144 DOI: 10.1002/emp2.12722
Source DB: PubMed Journal: J Am Coll Emerg Physicians Open ISSN: 2688-1152
Demographics
| Total (n = 507) | Pre‐COVID (n = 249) | COVID (n = 258) |
|
|---|---|---|---|
| Age, y (mean ± SD) | 10.49 ± 3.41 | 10.36 ± 3.70 | 0.69 |
| Gender | |||
| Male | 146 (58.6) | 138 (53.5) | 0.24 |
| Female | 103 (41.4) | 120 (46.5) | |
| Race/ethnicity | |||
| White | 86 (34.7) | 91 (35.7) | 0.73 |
| Hispanic | 142 (57.3) | 139 (54.5) | |
| Other | 20 (8.0) | 25 (9.8) | |
| Insurance status | |||
| Commercial | 103 (41.4) | 122 (47.3) | 0.39 |
| Public | 127 (51.0) | 120 (46.5) | |
| Self‐pay | 19 (7.6) | 16 (6.2) | |
| COVID status (positive or negative) | 0 | 9: 222 (36 unknown) |
There is a discrepancy in the totals as 4 patients were missing data on race/ethnicity.
Evaluation and treatment for pediatric appendicitis during the COVID‐19 pandemic
| Column1 | Pre‐COVID (n = 249) | COVID (n = 258) |
|
|---|---|---|---|
| Required CT | |||
| Yes | 88 (35.3) | 121 (46.9) | 0.008 |
| No | 161 (64.7) | 137 (53.1) | |
| Duration of symptoms on presentation, h, median (IQR) | 24 (15–48) | 24 (24–48) | 0.27 |
| Duration of symptoms on presentation | |||
| <24 h | 116 (54.7) | 144 (57.1) | 0.60 |
| >24 h | 96 (45.3) | 108 (42.9) | |
| Complicated | |||
| Yes | 74 (30.0) | 83 (32.2) | 0.59 |
| No | 173 (70.0) | 175 (67.8) | |
| Trips to the OR | |||
| 0 or 1 | 237 (96.3) | 254 (98.5) | 0.14 |
| 2 or more | 9 (3.7) | 4 (1.6) | |
| Received appendectomy | |||
| Yes | 247 (99.2) | 255 (98.8) | 0.52 |
| No | 2 (0.8) | 3 (1.2) | |
| Appendectomy type | |||
| Laparoscopy | 244 (99.2) | 253 (99.2) | 1 |
| Open | 1 (0.4) | 1 (0.4) | |
| Laparoscopy converted to open | 1 (0.4) | 1 (0.4) | |
| ED LOS, h, mean ± STD | 256.3 ± 108.4 | 267.7 ± 106.4 | 0.24 |
| LOS, days, median (IQR) | 0 (0–3) | 0 (0–3) | 0.38 |
| Pathology findings | |||
| Acute | |||
| YES | 164 (65.9) | 184 (71.3) | 0.19 |
| NO | 85 (34.1) | 74 (28.7) | |
| Gangrenous/necrotizing | |||
| YES | 38 (15.3) | 29 (11.2) | 0.18 |
| NO | 211 (84.7) | 229 (88.8) | |
| Micro perforation | |||
| YES | 13 (5.2) | 18 (7.0) | 0.41 |
| NO | 236 (94.8) | 240 (93.0) | |
| Perforation | |||
| YES | 53 (21.3) | 49 (19.0) | 0.52 |
| NO | 196 (78.7) | 209 (81.0) | |
| Operative findings | |||
| Acute | |||
| YES | 167 (67.1) | 160 (62.0) | 0.24 |
| NO | 82 (32.9) | 98 (38.0) | |
| Gangrenous/necrotizing | |||
| YES | 19 (7.6) | 18 (7.0) | 0.78 |
| NO | 230 (92.4) | 240 (93.0) | |
| Micro perforation | |||
| YES | 70 (28.1) | 80 (31.0) | 0.48 |
| NO | 179 (71.9) | 178 (69.0) | |
| Abscess | |||
| YES | 15 (6.0) | 24 (9.3) | 0.17 |
| NO | 234 (94.0) | 234 (90.7) | |
| Complicated appendix parameters | |||
| Visible perforation | |||
| YES | 65 (26.1) | 74 (28.7) | 0.52 |
| NO | 184 (73.9) | 184 (71.3) | |
| Abscess | |||
| YES | 16 (6.4) | 25 (9.7) | 0.18 |
| NO | 233 (93.6) | 233 (90.3) | |
| Diffuse fibrinopurulent exudate | |||
| YES | 33 (13.3) | 10 (3.9) | <0.001 |
| NO | 216 (86.8) | 248 (96.1) | |
| Extraluminal fecalith | |||
| YES | 3 (1.2) | 1 (0.4) | 0.3 |
| NO | 246 (98.8) | 257 (99.6) | |
| PICU admission | |||
| YES | 2 (0.8) | 3 (1.2) | 0.68 |
| NO | 247 (99.2) | 255 (98.8) | |
| Post‐operative complications | |||
| Wound infection | |||
| YES | 1 (0.4) | 1 (0.4) | 1 |
| NO | 246 (99.6) | 254 (99.6) | |
| Intra‐abdominal abscess | |||
| YES | 9 (3.6) | 7 (2.8) | 0.62 |
| NO | 238 (96.4) | 248 (97.3) | |
| Bowel obstruction | |||
| YES | 1 (0.4) | 1 (0.4) | 1 |
| NO | 245 (99.6) | 254 (99.6) | |
| DVT | |||
| YES | 0 (0.0) | 0 (0.0) | |
| NO | 0 (0.0) | 0 (0.0) | |
| Bleeding requiring transfusion | |||
| YES | 2 (0.8) | 0 (0.0) | 0.24 |
| NO | 245 (99.2) | 255 (100.0) | |
| Damage to nearby structure | |||
| YES | 0 (0.0) | 1 (0.4) | 1 |
| NO | 247 (100.0) | 254 (99.6) | |
| Pneumonia | |||
| YES | 0 (0.0) | 1 (0.4) | 1 |
| NO | 247 (100.0) | 254 (99.6) | |
| Needed post‐operative IR | |||
| YES | 7 (2.8) | 2 (0.8) | 0.1 |
| NO | 240 (97.2) | 253 (99.2) | |
| Needed post‐operative operation | |||
| YES | 2 (0.8) | 2 (0.8) | 1 |
| NO | 244 (99.2) | 253 (99.2) | |
Imaging used by year
| Modality | 2019 | 2020 | Total |
|---|---|---|---|
| Ultrasound only | 151 | 130 | 281 |
| CT only | 29 | 43 | 72 |
| Both modalities | 59 | 78 | 137 |
| Total | 239 | 251 | 490 |
Odds of CT scan usage pre‐ and post‐COVID
| Univariate | Pre‐COVID (n = 249) | COVID (n = 258) | 95% CI |
|
|---|---|---|---|---|
| Required CT | 1.0 (referent) | OR = 1.62 | 1.13–2.31 | 0.008 |
| Multivariate | Pre‐COVID (n = 249) | COVID (n = 258) | 95% CI |
|
| Required CT | 1.0 (referent) | OR = 1.81 | 1.21–2.69 | 0.004 |
| Duration of symptoms | OR = 0.85 | 0.58–1.25 | 0.403 | |
| Gender | OR = 0.99 | 0.68–1.44 | 0.941 | |
| Race/ethnicity | OR = 1.10 | 0.70–1.73 | 0.680 | |
| Insurance status | OR = 0.78 | 0.51–1.21 | 0.272 | |
| Age, y | OR = 0.97 | 0.92–1.02 | 0.217 |
Abbreviations: CI, confidence interval; COVID, coronavirus disease; CT, computed tomography; OR, odds ratio.