Literature DB >> 35461727

Neuroinflammation associated with ultrasound-mediated permeabilization of the blood-brain barrier.

Olive Jung1, Alec Thomas2, Scott R Burks3, Michael L Dustin4, Joseph A Frank5, Marc Ferrer6, Eleanor Stride7.   

Abstract

The blood-brain barrier (BBB) continues to represent one of the most significant challenges for successful drug-based treatments of neurological disease. Mechanical modulation of the BBB using focused ultrasound (FUS) and microbubbles (MBs) has shown considerable promise in enhancing the delivery of therapeutics to the brain, but questions remain regarding possible long-term effects of such forced disruption. This review examines the evidence for inflammation associated with ultrasound-induced BBB disruption and potential strategies for managing such inflammatory effects to improve both the efficacy and safety of therapeutic ultrasound in neurological applications.
Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.

Entities:  

Keywords:  blood–brain barrier; cavitation; focused ultrasound; immunomodulation; immunoprivilege; microbubbles; neurological disease; neurovasculature; sterile inflammation

Mesh：

Year:  2022        PMID： 35461727      PMCID： PMC9117477          DOI： 10.1016/j.tins.2022.03.003

Source DB:  PubMed          Journal:  Trends Neurosci        ISSN： 0166-2236            Impact factor:   16.978


  24 in total

Review 1.  Astrocyte-endothelial interactions at the blood-brain barrier.

Authors:  N Joan Abbott; Lars Rönnbäck; Elisabeth Hansson
Journal:  Nat Rev Neurosci       Date:  2006-01       Impact factor: 34.870

2.  Blood-brain barrier dysfunction in immuno-mediated neurological diseases.

Authors:  Fumitaka Shimizu; Hideaki Nishihara; Takashi Kanda
Journal:  Immunol Med       Date:  2018-11-30

Review 3.  Vascular pathology in multiple sclerosis: reframing pathogenesis around the blood-brain barrier.

Authors:  Jonathan I Spencer; Jack S Bell; Gabriele C DeLuca
Journal:  J Neurol Neurosurg Psychiatry       Date:  2017-08-31       Impact factor: 10.154

4.  Extensive frontal focused ultrasound mediated blood-brain barrier opening for the treatment of Alzheimer's disease: a proof-of-concept study.

Authors:  So Hee Park; Kyoungwon Baik; Seun Jeon; Won Seok Chang; Byoung Seok Ye; Jin Woo Chang
Journal:  Transl Neurodegener       Date:  2021-11-05       Impact factor: 8.014

5.  Blood-Brain Barrier Opening with MRI-guided Focused Ultrasound Elicits Meningeal Venous Permeability in Humans with Early Alzheimer Disease.

Authors:  Rashi I Mehta; Jeffrey S Carpenter; Rupal I Mehta; Marc W Haut; Manish Ranjan; Umer Najib; Paul Lockman; Peng Wang; Pierre-François D'haese; Ali R Rezai
Journal:  Radiology       Date:  2021-01-05       Impact factor: 11.105

6.  Safety evaluation of a clinical focused ultrasound system for neuronavigation guided blood-brain barrier opening in non-human primates.

Authors:  Antonios N Pouliopoulos; Nancy Kwon; Greg Jensen; Anna Meaney; Yusuke Niimi; Mark T Burgess; Robin Ji; Alicia J McLuckie; Fabian A Munoz; Hermes A S Kamimura; Andrew F Teich; Vincent P Ferrera; Elisa E Konofagou
Journal:  Sci Rep       Date:  2021-07-22       Impact factor: 4.379

7.  Vascular dysfunction-The disregarded partner of Alzheimer's disease.

Authors:  Melanie D Sweeney; Axel Montagne; Abhay P Sagare; Daniel A Nation; Lon S Schneider; Helena C Chui; Michael G Harrington; Judy Pa; Meng Law; Danny J J Wang; Russell E Jacobs; Fergus N Doubal; Joel Ramirez; Sandra E Black; Maiken Nedergaard; Helene Benveniste; Martin Dichgans; Costantino Iadecola; Seth Love; Philip M Bath; Hugh S Markus; Rustam Al-Shahi Salman; Stuart M Allan; Terence J Quinn; Rajesh N Kalaria; David J Werring; Roxana O Carare; Rhian M Touyz; Steve C R Williams; Michael A Moskowitz; Zvonimir S Katusic; Sarah E Lutz; Orly Lazarov; Richard D Minshall; Jalees Rehman; Thomas P Davis; Cheryl L Wellington; Hector M González; Chun Yuan; Samuel N Lockhart; Timothy M Hughes; Christopher L H Chen; Perminder Sachdev; John T O'Brien; Ingmar Skoog; Leonardo Pantoni; Deborah R Gustafson; Geert Jan Biessels; Anders Wallin; Eric E Smith; Vincent Mok; Adrian Wong; Peter Passmore; Frederick Barkof; Majon Muller; Monique M B Breteler; Gustavo C Román; Edith Hamel; Sudha Seshadri; Rebecca F Gottesman; Mark A van Buchem; Zoe Arvanitakis; Julie A Schneider; Lester R Drewes; Vladimir Hachinski; Caleb E Finch; Arthur W Toga; Joanna M Wardlaw; Berislav V Zlokovic
Journal:  Alzheimers Dement       Date:  2019-01       Impact factor: 16.655

8.  Blood-brain barrier opening in Alzheimer's disease using MR-guided focused ultrasound.

Authors:  Nir Lipsman; Ying Meng; Allison J Bethune; Yuexi Huang; Benjamin Lam; Mario Masellis; Nathan Herrmann; Chinthaka Heyn; Isabelle Aubert; Alexandre Boutet; Gwenn S Smith; Kullervo Hynynen; Sandra E Black
Journal:  Nat Commun       Date:  2018-07-25       Impact factor: 14.919

9.  Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction.

Authors:  Daniel A Nation; Melanie D Sweeney; Axel Montagne; Abhay P Sagare; Lina M D'Orazio; Maricarmen Pachicano; Farshid Sepehrband; Amy R Nelson; David P Buennagel; Michael G Harrington; Tammie L S Benzinger; Anne M Fagan; John M Ringman; Lon S Schneider; John C Morris; Helena C Chui; Meng Law; Arthur W Toga; Berislav V Zlokovic
Journal:  Nat Med       Date:  2019-01-14       Impact factor: 53.440

10.  Are researchers moving away from animal models as a result of poor clinical translation in the field of stroke? An analysis of opinion papers.

Authors:  Pandora Pound; Rebecca Ram
Journal:  BMJ Open Sci       Date:  2020-02-24
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  2 in total

Review 1.  Effects of Sound Interventions on the Permeability of the Blood-Brain Barrier and Meningeal Lymphatic Clearance.

Authors:  Sean Sachdeva; Sushmita Persaud; Milani Patel; Peyton Popard; Aaron Colverson; Sylvain Doré
Journal:  Brain Sci       Date:  2022-06-05

Review 2.  In Vitro Modeling of the Blood-Brain Barrier for the Study of Physiological Conditions and Alzheimer's Disease.

Authors:  Thomas Gabriel Schreiner; Ioana Creangă-Murariu; Bogdan Ionel Tamba; Nicolae Lucanu; Bogdan Ovidiu Popescu
Journal:  Biomolecules       Date:  2022-08-18
  2 in total

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