Literature DB >> 3545805

A review of toxicology studies on cyanurate and its chlorinated derivatives.

B G Hammond, S J Barbee, T Inoue, N Ishida, G J Levinskas, M W Stevens, A G Wheeler, T Cascieri.   

Abstract

Chlorinated cyanurates are added to swimming pools as disinfectants. In the presence of water, these materials hydrolyze to yield cyanurate and hypochlorous acid. To evaluate the safety of exposure to these materials, a comprehensive testing program was undertaken. This review summarizes the results of acute and subchronic tests on chlorinated isocyanurates. Findings from acute, subchronic, reproduction, metabolism, mutagenicity, and chronic/carcinogenicity tests on cyanurate are also summarized. Results from these tests indicate that chlorinated isocyanurates are safe for use in swimming pools.

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Year:  1986        PMID： 3545805      PMCID： PMC1474314          DOI： 10.1289/ehp.8669287

Source DB:  PubMed          Journal:  Environ Health Perspect        ISSN： 0091-6765            Impact factor:   9.031


  3 in total

1.  [On the problem of the toxicity of cyanuric chloride].

Authors:  V M Blagodatin
Journal:  Gig Tr Prof Zabol       Date:  1968-08

2.  Absorption and excretion of cyanuric acid in long-distance swimmers.

Authors:  L M Allen; T V Briggle; C D Pfaffenberger
Journal:  Drug Metab Rev       Date:  1982       Impact factor: 4.518

3.  Absence of mutagenic activity for monosodium cyanurate.

Authors:  B G Hammond; S J Barbee; A G Wheeler; T Cascieri
Journal:  Fundam Appl Toxicol       Date:  1985-08
  3 in total
  18 in total

1.  Pharmacokinetics of melamine and cyanuric acid and their combinations in F344 rats.

Authors:  Cristina C Jacob; Linda S Von Tungeln; Michelle Vanlandingham; Frederick A Beland; Gonçalo Gamboa da Costa
Journal:  Toxicol Sci       Date:  2012-01-06       Impact factor: 4.849

2.  Dose-response assessment of nephrotoxicity from a 7-day combined exposure to melamine and cyanuric acid in F344 rats.

Authors:  Cristina C Jacob; Renate Reimschuessel; Linda S Von Tungeln; Greg R Olson; Alan R Warbritton; David G Hattan; Frederick A Beland; Gonçalo Gamboa da Costa
Journal:  Toxicol Sci       Date:  2010-10-28       Impact factor: 4.849

Review 3.  Melamine-related kidney stones and renal toxicity.

Authors:  Rishikesh P Dalal; David S Goldfarb
Journal:  Nat Rev Nephrol       Date:  2011-03-22       Impact factor: 28.314

4.  The mechanism of renal stone formation and renal failure induced by administration of melamine and cyanuric acid.

Authors:  Takahiro Kobayashi; Atsushi Okada; Yasuhiro Fujii; Kazuhiro Niimi; Shuzo Hamamoto; Takahiro Yasui; Keiichi Tozawa; Kenjiro Kohri
Journal:  Urol Res       Date:  2010-02-24

5.  Dose-response assessment of nephrotoxicity from a twenty-eight-day combined-exposure to melamine and cyanuric acid in F344 rats.

Authors:  Gonçalo Gamboa da Costa; Cristina C Jacob; Linda S Von Tungeln; Nicholas R Hasbrouck; Greg R Olson; David G Hattan; Renate Reimschuessel; Frederick A Beland
Journal:  Toxicol Appl Pharmacol       Date:  2012-05-02       Impact factor: 4.219

6.  Integrated preservation and sample clean up procedures for studying water ingestion by recreational swimmers via urinary biomarker determination.

Authors:  Ricardo Cantú; Jody A Shoemaker; Catherine A Kelty; Larry J Wymer; Thomas D Behymer; Alfred P Dufour; Matthew L Magnuson
Journal:  Anal Chim Acta       Date:  2017-06-19       Impact factor: 6.558

7.  Investigation of some disinfection chemicals and water quality parameters in swimming pools in the city center and districts of Canakkale, Turkey.

Authors:  Tolga Uysal; Selehattin Yilmaz; Muhammet Turkoglu; Murat Sadikoglu
Journal:  Environ Monit Assess       Date:  2017-06-16       Impact factor: 2.513

8.  Performance of urinary and gene expression biomarkers in detecting the nephrotoxic effects of melamine and cyanuric acid following diverse scenarios of co-exposure.

Authors:  Omari Bandele; Luísa Camacho; Martine Ferguson; Renate Reimschuessel; Cynthia Stine; Thomas Black; Nicholas Olejnik; Zachary Keltner; Michael Scott; Gonçalo Gamboa da Costa; Robert Sprando
Journal:  Food Chem Toxicol       Date:  2012-09-26       Impact factor: 6.023

9.  First Acid Ionization Constant of the Drinking Water Relevant Chemical Cyanuric Acid from 5 to 35 °C.

Authors:  David G Wahman
Journal:  Environ Sci (Camb)       Date:  2018       Impact factor: 4.251

10.  Cytotoxic and genotoxic effect in RTG-2 cell line exposed to selected biocides used in the disinfection of cooling towers.

Authors:  S Sánchez-Fortún; M T Llorente; A Castaño
Journal:  Ecotoxicology       Date:  2008-02-15       Impact factor: 2.823
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