Literature DB >> 354516

Microbial degradation of cephalothin by cephalothin-susceptible Escherichia coli.

T Nishiura, Y Kawada, Y Shiomi, K O'Hara, M Kono.   

Abstract

Cephalothin (CET)-susceptible Escherichia coli, which can degrade CET after prolonged incubation in broth containing a concentration of the drug greater than the minimum inhibitory concentration, was found in a clinical specimen. The substrate specificity of the partially purified enzyme to cephalosporin analogs strongly indicated the occurrence of CET-specific degradation. Nuclear magnetic resonance analysis of the degradation reaction demonstrated the appearance of two new signals attributed to deacetyl CET. This suggests the possibility of the presence of acylesterase.

Entities:  

Mesh：

Substances：

Year:  1978        PMID： 354516      PMCID： PMC352384          DOI： 10.1128/AAC.13.6.1036

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  12 in total

1.  PROPERTIES OF THE PENICILLIN DEACYLASE ENZYME OF ESCHERICHIA COLI.

Authors:  M COLE
Journal:  Nature       Date:  1964-08-01       Impact factor: 49.962

2.  MICROBIAL DEGRADATION OF CEPHALOSPORIN C.

Authors:  A L DEMAIN; R B WALTON; J F NEWKIRK; I M MILLER
Journal:  Nature       Date:  1963-08-31       Impact factor: 49.962

3.  Deacetylcephalosporin C.

Authors:  J D JEFFERY; E P ABRAHAM; G G NEWTON
Journal:  Biochem J       Date:  1961-12       Impact factor: 3.857

4.  Iodometric assay of penicillinase.

Authors:  C J PERRET
Journal:  Nature       Date:  1954-11-27       Impact factor: 49.962

5.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

6.  Hemodialysis-associated infections: treatment with cephapirin.

Authors:  S J Berman; W H Boughton; J G Sugihara; E G Wong; A W Siemsen
Journal:  Antimicrob Agents Chemother       Date:  1978-01       Impact factor: 5.191

7.  Antibacterial activity of chloramphenicol-related compounds toward a chloramphenicol-resistant strains of Staphylococcus aureus.

Authors:  M Kono; K O'Hara; M Nagawa; S Mitsuhashi
Journal:  Jpn J Microbiol       Date:  1972-11

8.  Resistance of Escherichia coli to penicillins. VI. Purification and characterization of the chromosomally mediated penicillinase present in ampA-containing strains.

Authors:  E B Linström; H G Boman; B B Steele
Journal:  J Bacteriol       Date:  1970-01       Impact factor: 3.490

9.  The purification and properties of penicillin beta-lactamases mediated by transmissible R factors in Escherichia coli.

Authors:  S Yamagishi; K O'Hara; T Sawai; S Mitsuhashi
Journal:  J Biochem       Date:  1969-07       Impact factor: 3.387

10.  Changes in proton-magnetic-resonance spectra during aminolysis and enzymic hydrolysis of cephalosporins.

Authors:  J M Hamilton-Miller; E Richards; E P Abraham
Journal:  Biochem J       Date:  1970-02       Impact factor: 3.857
View more
  2 in total

1.  Purification and characterization of macrolide 2'-phosphotransferase from a strain of Escherichia coli that is highly resistant to erythromycin.

Authors:  K O'Hara; T Kanda; K Ohmiya; T Ebisu; M Kono
Journal:  Antimicrob Agents Chemother       Date:  1989-08       Impact factor: 5.191

2.  Nuclear magnetic resonance spectrometric assay of beta-lactamase.

Authors:  M Kono; K O'Hara; Y Shiomi
Journal:  Antimicrob Agents Chemother       Date:  1980-01       Impact factor: 5.191
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.