Literature DB >> 35451092

The goodies of chelated fat: iron-regulated lipid droplet biogenesis precedes and preserves mitophagy.

Marc Liesa1,2.   

Abstract

The role of iron-regulated mitophagy in lipid metabolism is unclear. Recent work by Long, Sanchez-Martinez et al (2022) shows that iron chelation induces a primary change in lipid metabolism that promotes fat accumulation and precedes mitophagy.
© 2022 The Authors.

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Year:  2022        PMID： 35451092      PMCID： PMC9108591          DOI： 10.15252/embj.2022111238

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   14.012


  11 in total

1.  Iron metabolism and cell membranes. I. Relation between ferritin and hemosiderin in bile and biliary excretion of lysosome contents.

Authors:  W D Bradford; J G Elchlepp; A U Arstila; B F Trump; T D Kinney
Journal:  Am J Pathol       Date:  1969-08       Impact factor: 4.307

2.  Comparative study of iron mobilization from haemosiderin, ferritin and iron(III) precipitates by chelators.

Authors:  G J Kontoghiorghes; S Chambers; A V Hoffbrand
Journal:  Biochem J       Date:  1987-01-01       Impact factor: 3.857

3.  MIGA2 Links Mitochondria, the ER, and Lipid Droplets and Promotes De Novo Lipogenesis in Adipocytes.

Authors:  Christophe A C Freyre; Pascal C Rauher; Christer S Ejsing; Robin W Klemm
Journal:  Mol Cell       Date:  2019-10-15       Impact factor: 17.970

4.  The goodies of chelated fat: iron-regulated lipid droplet biogenesis precedes and preserves mitophagy.

Authors:  Marc Liesa
Journal:  EMBO J       Date:  2022-04-22       Impact factor: 14.012

Review 5.  Hepatic triacylglycerol synthesis and secretion: DGAT2 as the link between glycaemia and triglyceridaemia.

Authors:  Victor A Zammit
Journal:  Biochem J       Date:  2013-04-01       Impact factor: 3.857

6.  The endoplasmic reticulum enzyme DGAT2 is found in mitochondria-associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria.

Authors:  Scot J Stone; Malin C Levin; Ping Zhou; Jiayi Han; Tobias C Walther; Robert V Farese
Journal:  J Biol Chem       Date:  2008-12-01       Impact factor: 5.157

7.  Iron loss triggers mitophagy through induction of mitochondrial ferritin.

Authors:  Izumi Yanatori; Atsushi Tanaka; Yuichi Hara; Fumio Kishi; John J Lemasters; Sohji Nishina; Kyo Sasaki; Keisuke Hino
Journal:  EMBO Rep       Date:  2020-09-25       Impact factor: 8.807

8.  DGAT1 activity synchronises with mitophagy to protect cells from metabolic rewiring by iron  depletion.

Authors:  Maeve Long; Alvaro Sanchez-Martinez; Marianna Longo; Fumi Suomi; Hans Stenlund; Annika I Johansson; Homa Ehsan; Veijo T Salo; Lambert Montava-Garriga; Seyedehshima Naddafi; Elina Ikonen; Ian G Ganley; Alexander J Whitworth; Thomas G McWilliams
Journal:  EMBO J       Date:  2022-04-12       Impact factor: 14.012

9.  Reduction in mitochondrial iron alleviates cardiac damage during injury.

Authors:  Hsiang-Chun Chang; Rongxue Wu; Meng Shang; Tatsuya Sato; Chunlei Chen; Jason S Shapiro; Ting Liu; Anita Thakur; Konrad T Sawicki; Sathyamangla V N Prasad; Hossein Ardehali
Journal:  EMBO Mol Med       Date:  2016-03-01       Impact factor: 12.137

10.  The SUMO protease SENP3 regulates mitochondrial autophagy mediated by Fis1.

Authors:  Emily Waters; Kevin A Wilkinson; Amy L Harding; Ruth E Carmichael; Darren Robinson; Helen E Colley; Chun Guo
Journal:  EMBO Rep       Date:  2022-01-07       Impact factor: 9.071
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  1 in total

1.  The goodies of chelated fat: iron-regulated lipid droplet biogenesis precedes and preserves mitophagy.

Authors:  Marc Liesa
Journal:  EMBO J       Date:  2022-04-22       Impact factor: 14.012
  1 in total

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