| Literature DB >> 35431352 |
Laura Flores-Bocanegra1, Mario Augustinović1, Huzefa A Raja1, Steven J Kurina2, Amanda C Maldonado2, Joanna E Burdette2, Joseph O Falkinham3, Cedric J Pearce4, Nicholas H Oberlies1.
Abstract
As part of our ongoing research on bioactive fungal metabolites, two new metabolites were isolated from a fungus of the Stictidaceae (strain MSX62440), dasyscyphins F and G (1 and 3), and the known dasyscyphin C (2). Compound 1 was characterized by HRMS and 1D and 2D NMR data, and its absolute configuration established by ECD spectroscopy. A structural revision of dasyscyphin C (2) was based on NMR data and verified by ECD calculations. Compound 3 was reported previously as a synthetic product, and its identity confirmed by comparison with NMR data in the literature, and its absolute configuration was established by ECD spectroscopy. Compounds 1 and 2 showed moderate cytotoxicity and antimicrobial activity.Entities:
Keywords: Stictidaceae sp.; antimicrobial; cytotoxic; dasyscyphins; meroterpenoids
Year: 2021 PMID： 35431352 PMCID： PMC9012486 DOI： 10.1016/j.tetlet.2021.152896
Source DB: PubMed Journal: Tetrahedron Lett ISSN： 0040-4039 Impact factor: 2.032