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Literature DB >> 3543113

Therapeutic and toxic effects of digitalis: William Withering, 1785.

Abstract

William Withering's classic description of the effects of digitalis was published in 1785. Although he was largely unaware of the drug's cardiac effects, he successfully treated many patients with congestive heart failure. He also recorded many striking examples of digitalis toxicity. This review highlights Withering's experience with "the foxglove," and summarizes modern concepts of digitalis efficacy and toxicity.

Entities: Disease Species

Mesh：

Substances：
Digitalis Glycosides

Year: 1986 PMID： 3543113 DOI： 10.1016/0736-4679(86)90048-x

Source DB: PubMed Journal: J Emerg Med ISSN： 0736-4679 Impact factor: 1.484

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Cited

11 in total

Review 1. Novel role of ouabain as a cystogenic factor in autosomal dominant polycystic kidney disease.

Authors: Gustavo Blanco; Darren P Wallace
Journal: Am J Physiol Renal Physiol Date: 2013-06-12

Review 2. Cardiac glycosides in cancer therapy: from preclinical investigations towards clinical trials.

Authors: M Slingerland; C Cerella; H J Guchelaar; M Diederich; H Gelderblom
Journal: Invest New Drugs Date: 2013-06-10 Impact factor: 3.850

Review 3. Teaching an old dog new tricks: Drug discovery by repositioning natural products and their derivatives.

Authors: Boshi Huang; Yan Zhang
Journal: Drug Discov Today Date: 2022-02-16 Impact factor: 8.369

4. Analysis of proliferation and apoptotic induction by 20 steroid glycosides in 143B osteosarcoma cells in vitro.

Authors: C I Delebinski; S Georgi; S Kleinsimon; M Twardziok; B Kopp; M F Melzig; G Seifert
Journal: Cell Prolif Date: 2015-08-24 Impact factor: 6.831

Review 5. Cardiac glycosides use and the risk and mortality of cancer; systematic review and meta-analysis of observational studies.

Authors: Mohamed Hosny Osman; Eman Farrag; Mai Selim; Mohamed Samy Osman; Arwa Hasanine; Azza Selim
Journal: PLoS One Date: 2017-06-07 Impact factor: 3.240

Therapeutic and toxic effects of digitalis: William Withering, 1785.

Review 1. Novel role of ouabain as a cystogenic factor in autosomal dominant polycystic kidney disease.

Review 2. Cardiac glycosides in cancer therapy: from preclinical investigations towards clinical trials.

Review 3. Teaching an old dog new tricks: Drug discovery by repositioning natural products and their derivatives.

4. Analysis of proliferation and apoptotic induction by 20 steroid glycosides in 143B osteosarcoma cells in vitro.

Review 5. Cardiac glycosides use and the risk and mortality of cancer; systematic review and meta-analysis of observational studies.

Review 6. On the Many Actions of Ouabain: Pro-Cystogenic Effects in Autosomal Dominant Polycystic Kidney Disease.

7. Naturally Occurring Cardenolides Affecting Schistosoma mansoni.

Review 8. Na/K-ATPase Signaling and Cardiac Pre/Postconditioning with Cardiotonic Steroids.

Review 9. Anticancer and Immunogenic Properties of Cardiac Glycosides.

10. Discovery and optimization of cardenolides inhibiting HSF1 activation in human colon HCT-116 cancer cells.