Chaoqun Zhang1, Yipeng Wu2, Yongqing Xu2. 1. Graduate School of Kunming Medical University, Kunming Yunnan, 650000, P. R. China. 2. Institute of All-Army Trauma Orthopaedics, No.920 Hospital of PLA Joint Service Support Force, Kunming Yunnan, 650032, P. R. China.
Abstract
Objective: To summarize the related research progress of antibacterial modification of orthopaedic implants surface in recent years. Methods: The domestic and foreign related literature in recent years was extensively consulted, the research progress on antibacterial modification of orthopaedic implants surface was discussed from two aspects of characteristics of infection in orthopedic implants and surface anti-infection modification. Results: The orthopaedic implants infections are mainly related to aspects of bacterial adhesion, decreased host immunity, and surface biofilm formation. At present, the main antimicrobial coating methods of orthopaedic implants are antibacterial adhesion coating, antibiotic coating, inorganic antimicrobial coating, composite antimicrobial coating, nitric oxide coating, immunomodulation, three-dimensional printing, polymer antimicrobial coating, and "smart" coating. Conclusion: The above-mentioned antibacterial coating methods of orthopedic implants can not only inhibit bacterial adhesion, but also solve the problems of low immunity and biofilm formation. However, its mechanism of action and modification are still controversial and require further research.
Objective: To summarize the related research progress of antibacterial modification of orthopaedic implants surface in recent years. Methods: The domestic and foreign related literature in recent years was extensively consulted, the research progress on antibacterial modification of orthopaedic implants surface was discussed from two aspects of characteristics of infection in orthopedic implants and surface anti-infection modification. Results: The orthopaedic implants infections are mainly related to aspects of bacterial adhesion, decreased host immunity, and surface biofilm formation. At present, the main antimicrobial coating methods of orthopaedic implants are antibacterial adhesion coating, antibiotic coating, inorganic antimicrobial coating, composite antimicrobial coating, nitric oxide coating, immunomodulation, three-dimensional printing, polymer antimicrobial coating, and "smart" coating. Conclusion: The above-mentioned antibacterial coating methods of orthopedic implants can not only inhibit bacterial adhesion, but also solve the problems of low immunity and biofilm formation. However, its mechanism of action and modification are still controversial and require further research.
Authors: Dawn M E Bowdish; Donald J Davidson; Y Elaine Lau; Ken Lee; Monisha G Scott; Robert E W Hancock Journal: J Leukoc Biol Date: 2004-11-29 Impact factor: 4.962
Authors: Nan Jiang; Devendra H Dusane; Jacob R Brooks; Craig P Delury; Sean S Aiken; Phillip A Laycock; Paul Stoodley Journal: Sci Rep Date: 2021-01-14 Impact factor: 4.379