Literature DB >> 35419481

Genome-wide CRISPR screening reveals novel therapeutic targets in RIT1-driven lung cancer.

Amanda K Riley1,2, Alice H Berger1.   

Abstract

In recent work, we performed CRISPR/Cas9 screening in RIT1 (Ras-like in all tissues)-mutant cancer cells. We found that RIT1-mutant cells are vulnerable to loss of mitotic regulators, and mutant RIT1 synergizes with YAP1 (yes-associated protein 1) in oncogenesis. These findings can be leveraged to identify targeted therapies for RIT1-mutant cancer.
© 2021 Taylor & Francis Group, LLC.

Entities:  

Keywords:  Aurora kinases; Lung adenocarcinoma; RIT1; YAP1; spindle assembly checkpoint

Year:  2021        PMID： 35419481      PMCID： PMC8997261          DOI： 10.1080/23723556.2021.2000318

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  9 in total

Review 1.  The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics.

Authors:  Andrea Musacchio
Journal:  Curr Biol       Date:  2015-10-19       Impact factor: 10.834

2.  Gain-of-function mutations in RIT1 cause Noonan syndrome, a RAS/MAPK pathway syndrome.

Authors:  Yoko Aoki; Tetsuya Niihori; Toshihiro Banjo; Nobuhiko Okamoto; Seiji Mizuno; Kenji Kurosawa; Tsutomu Ogata; Fumio Takada; Michihiro Yano; Toru Ando; Tadataka Hoshika; Christopher Barnett; Hirofumi Ohashi; Hiroshi Kawame; Tomonobu Hasegawa; Takahiro Okutani; Tatsuo Nagashima; Satoshi Hasegawa; Ryo Funayama; Takeshi Nagashima; Keiko Nakayama; Shin-Ichi Inoue; Yusuke Watanabe; Toshihiko Ogura; Yoichi Matsubara
Journal:  Am J Hum Genet       Date:  2013-06-20       Impact factor: 11.025

3.  High-throughput Phenotyping of Lung Cancer Somatic Mutations.

Authors:  Alice H Berger; Angela N Brooks; Xiaoyun Wu; Yashaswi Shrestha; Candace Chouinard; Federica Piccioni; Mukta Bagul; Atanas Kamburov; Marcin Imielinski; Larson Hogstrom; Cong Zhu; Xiaoping Yang; Sasha Pantel; Ryo Sakai; Jacqueline Watson; Nathan Kaplan; Joshua D Campbell; Shantanu Singh; David E Root; Rajiv Narayan; Ted Natoli; David L Lahr; Itay Tirosh; Pablo Tamayo; Gad Getz; Bang Wong; John Doench; Aravind Subramanian; Todd R Golub; Matthew Meyerson; Jesse S Boehm
Journal:  Cancer Cell       Date:  2016-07-28       Impact factor: 31.743

4.  Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.

Authors:  Hyuna Sung; Jacques Ferlay; Rebecca L Siegel; Mathieu Laversanne; Isabelle Soerjomataram; Ahmedin Jemal; Freddie Bray
Journal:  CA Cancer J Clin       Date:  2021-02-04       Impact factor: 508.702

Review 5.  Mechanisms of Hippo pathway regulation.

Authors:  Zhipeng Meng; Toshiro Moroishi; Kun-Liang Guan
Journal:  Genes Dev       Date:  2016-01-01       Impact factor: 11.361

6.  Novel recurrent mutations in the RAS-like GTP-binding gene RIT1 in myeloid malignancies.

Authors:  I Gómez-Seguí; H Makishima; A Jerez; K Yoshida; B Przychodzen; S Miyano; Y Shiraishi; H D Husseinzadeh; K Guinta; M Clemente; N Hosono; M A McDevitt; A R Moliterno; M A Sekeres; S Ogawa; J P Maciejewski
Journal:  Leukemia       Date:  2013-06-14       Impact factor: 11.528

7.  Comprehensive molecular profiling of lung adenocarcinoma.

Authors: 
Journal:  Nature       Date:  2014-07-09       Impact factor: 49.962

8.  Oncogenic RIT1 mutations in lung adenocarcinoma.

Authors:  A H Berger; M Imielinski; F Duke; J Wala; N Kaplan; G-X Shi; D A Andres; M Meyerson
Journal:  Oncogene       Date:  2014-01-27       Impact factor: 9.867

9.  Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer.

Authors:  Athea Vichas; Amanda K Riley; Naomi T Nkinsi; Shriya Kamlapurkar; Phoebe C R Parrish; April Lo; Fujiko Duke; Jennifer Chen; Iris Fung; Jacqueline Watson; Matthew Rees; Austin M Gabel; James D Thomas; Robert K Bradley; John K Lee; Emily M Hatch; Marina K Baine; Natasha Rekhtman; Marc Ladanyi; Federica Piccioni; Alice H Berger
Journal:  Nat Commun       Date:  2021-08-09       Impact factor: 14.919
  9 in total

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