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Literature DB >> 35419470

A mitochondrial response to oxidative stress mediated by unscheduled RNA-DNA hybrids (R-loops).

Xavier Renaudin¹, Ashok R Venkitaraman².

Abstract

How oxidative stress promotes aging-related human diseases like cancer and neurodegeneration remains unclear. Here, we discuss the origins and implications of an oxidative-stress response recently reported to destabilize the mitochondrial (mt) genome via unscheduled RNA/DNA hybrid (R-loop) accumulation, by impairing the recruitment of RNAseH1 to the regulatory regions of mtDNA.

Entities: Chemical

Keywords: BRCA2; Oxidative stress; PRPF8; R-loops; RNA-DNA hybrid; SETX; cancer; genomic instability; mitochondria; mtDNA replication; neurodegeneration

Year: 2021 PMID： 35419470 PMCID： PMC8997250 DOI： 10.1080/23723556.2021.2007028

Source DB: PubMed Journal: Mol Cell Oncol ISSN： 2372-3556

9 in total

1. A mitochondrial bioenergetic etiology of disease.

Authors: Douglas C Wallace
Journal: J Clin Invest Date: 2013-04-01 Impact factor: 14.808

2. Targeted and Persistent 8-Oxoguanine Base Damage at Telomeres Promotes Telomere Loss and Crisis.

Authors: Elise Fouquerel; Ryan P Barnes; Shikhar Uttam; Simon C Watkins; Marcel P Bruchez; Patricia L Opresko
Journal: Mol Cell Date: 2019-05-14 Impact factor: 17.970

Review 3. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases.

Authors: Michael T Lin; M Flint Beal
Journal: Nature Date: 2006-10-19 Impact factor: 49.962

4. Mitochondrial DNA drives abscopal responses to radiation that are inhibited by autophagy.

Authors: Takahiro Yamazaki; Alexander Kirchmair; Ai Sato; Aitziber Buqué; Marissa Rybstein; Giulia Petroni; Norma Bloy; Francesca Finotello; Lena Stafford; Esther Navarro Manzano; Francisco Ayala de la Peña; Elena García-Martínez; Silvia C Formenti; Zlatko Trajanoski; Lorenzo Galluzzi
Journal: Nat Immunol Date: 2020-08-03 Impact factor: 25.606

5. Mitochondrial DNA copy number variation across human cancers.

Authors: Ed Reznik; Martin L Miller; Yasin Şenbabaoğlu; Nadeem Riaz; Judy Sarungbam; Satish K Tickoo; Hikmat A Al-Ahmadie; William Lee; Venkatraman E Seshan; A Ari Hakimi; Chris Sander
Journal: Elife Date: 2016-02-22 Impact factor: 8.140

6. The mitochondrial R-loop.

Authors: Ian J Holt
Journal: Nucleic Acids Res Date: 2019-06-20 Impact factor: 16.971

7. Mitochondrial DNA stress primes the antiviral innate immune response.

Authors: A Phillip West; William Khoury-Hanold; Matthew Staron; Michal C Tal; Cristiana M Pineda; Sabine M Lang; Megan Bestwick; Brett A Duguay; Nuno Raimundo; Donna A MacDuff; Susan M Kaech; James R Smiley; Robert E Means; Akiko Iwasaki; Gerald S Shadel
Journal: Nature Date: 2015-02-02 Impact factor: 49.962

8. Oxidative DNA damage stalls the human mitochondrial replisome.

Authors: Gorazd Stojkovič; Alena V Makarova; Paulina H Wanrooij; Josefin Forslund; Peter M Burgers; Sjoerd Wanrooij
Journal: Sci Rep Date: 2016-07-01 Impact factor: 4.379

9. BRCA2 deficiency reveals that oxidative stress impairs RNaseH1 function to cripple mitochondrial DNA maintenance.

Authors: Xavier Renaudin; Miyoung Lee; Mona Shehata; Eva-Maria Surmann; Ashok R Venkitaraman
Journal: Cell Rep Date: 2021-08-03 Impact factor: 9.423

9 in total

2 in total

1. Pro-inflammatory RNA:DNA Hybrids Are p53 Independently Boosted by Hyperbaric Oxygen: a Subcellular Distribution Analysis by Automated Quantitative Imaging.

Authors: Ilaria De Santis; Michele Zanoni; Sara Pignatta; Pasquale Longobardi; Anna Tesei; Alessandro Bevilacqua
Journal: Mol Imaging Biol Date: 2022-10-19 Impact factor: 3.484

Review 2. Future Perspectives in Oxidative Stress in Trisomy 13 and 18 Evaluation.

Authors: Angelika Buczyńska; Iwona Sidorkiewicz; Ahsan Hameed; Adam Jacek Krętowski; Monika Zbucka-Krętowska
Journal: J Clin Med Date: 2022-03-24 Impact factor: 4.241

2 in total