Literature DB >> 35419469

Turning end-joining upside down in mitosis.

Marta Llorens-Agost1, Michael Ensminger1, Hang Phuong Le2, Wolf-Dietrich Heyer2, Markus Löbrich1.   

Abstract

How cells deal with DNA breaks during mitosis is not well understood. While canonical non-homologous end-joining predominates in interphase, it is inhibited in mitosis to avoid telomere fusions. DNA polymerase θ mediated end-joining appears to be repressed in interphase, but promotes break repair in mitosis. The nature and induction time of breaks might determine their fate during mitosis.
© 2021 Taylor & Francis Group, LLC.

Entities:  

Keywords:  DNA repair; TMEJ; c-NHEJ; mitosis; tethering

Year:  2021        PMID： 35419469      PMCID： PMC8997260          DOI： 10.1080/23723556.2021.2007029

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  The impact of a negligent G2/M checkpoint on genomic instability and cancer induction.

Authors:  Markus Löbrich; Penny A Jeggo
Journal:  Nat Rev Cancer       Date:  2007-11       Impact factor: 60.716

2.  Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination.

Authors:  Pedro A Mateos-Gomez; Fade Gong; Nidhi Nair; Kyle M Miller; Eros Lazzerini-Denchi; Agnel Sfeir
Journal:  Nature       Date:  2015-02-02       Impact factor: 49.962

3.  Mitosis inhibits DNA double-strand break repair to guard against telomere fusions.

Authors:  Alexandre Orthwein; Amélie Fradet-Turcotte; Sylvie M Noordermeer; Marella D Canny; Catherine M Brun; Jonathan Strecker; Cristina Escribano-Diaz; Daniel Durocher
Journal:  Science       Date:  2014-03-20       Impact factor: 47.728

4.  POLθ-mediated end joining is restricted by RAD52 and BRCA2 until the onset of mitosis.

Authors:  Marta Llorens-Agost; Michael Ensminger; Hang Phuong Le; Anugrah Gawai; Jie Liu; Andrés Cruz-García; Sarita Bhetawal; Richard D Wood; Wolf-Dietrich Heyer; Markus Löbrich
Journal:  Nat Cell Biol       Date:  2021-10-06       Impact factor: 28.213

5.  DNA damage signaling in response to double-strand breaks during mitosis.

Authors:  Simona Giunta; Rimma Belotserkovskaya; Stephen P Jackson
Journal:  J Cell Biol       Date:  2010-07-26       Impact factor: 10.539

6.  MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis.

Authors:  Pia-Amata Leimbacher; Samuel E Jones; Ann-Marie K Shorrocks; Mara de Marco Zompit; Matthew Day; Jordy Blaauwendraad; Diana Bundschuh; Sarah Bonham; Roman Fischer; Daniel Fink; Benedikt M Kessler; Antony W Oliver; Laurence H Pearl; Andrew N Blackford; Manuel Stucki
Journal:  Mol Cell       Date:  2019-03-18       Impact factor: 17.970

7.  A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1.

Authors:  Xiao-Feng Zheng; Sanket S Acharya; Katherine N Choe; Kumar Nikhil; Guillaume Adelmant; Shakti Ranjan Satapathy; Samanta Sharma; Keith Viccaro; Sandeep Rana; Amarnath Natarajan; Peter Sicinski; Jarrod A Marto; Kavita Shah; Dipanjan Chowdhury
Journal:  Nat Commun       Date:  2019-09-18       Impact factor: 14.919

8.  Persistent DNA damage signaling and DNA polymerase theta promote broken chromosome segregation.

Authors:  Delisa E Clay; Heidi S Bretscher; Erin A Jezuit; Korie B Bush; Donald T Fox
Journal:  J Cell Biol       Date:  2021-10-06       Impact factor: 8.077

9.  Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair.

Authors:  Raphael Ceccaldi; Jessica C Liu; Ravindra Amunugama; Ildiko Hajdu; Benjamin Primack; Mark I R Petalcorin; Kevin W O'Connor; Panagiotis A Konstantinopoulos; Stephen J Elledge; Simon J Boulton; Timur Yusufzai; Alan D D'Andrea
Journal:  Nature       Date:  2015-02-02       Impact factor: 69.504
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.