Literature DB >> 35419161

5-Fluorouracil Neurotoxicity in the Absence of Dihydropyrimidine Dehydrogenase Deficiency Case Report.

Rebecca Jules1, Arushi Thaper2, Ryan Foster2, Pouya Ameli3, Christopher Robinson3, Michael Pizzi3, Marc-Alain Babi3, Carolina B Maciel3, Katharina M Busl3, Raju Reddy4, William Roth3.   

Abstract

5 fluorouracil (5-FU)-related neurotoxicity is a rare and severe complication of 5-FU administration. Dihydropyrimidine dehydrogenase (DPD) deficiency is associated with an increased risk of serious adverse reactions due to its role in 5-FU metabolism. We report a case of acute reversible neurotoxicity with global areas of diffusion restriction in a patient with colorectal adenocarcinoma being treated with leucovorin calcium, 5-fluorouracil, and oxaliplatin (FOLFOX) without DPD deficiency following uridine triacetate administration.
© The Author(s) 2022.

Entities:  

Keywords:  5 fluorouracil; case report; dihydropyrimidine dehydrogenase; neurotoxicity; status epilepticus

Year:  2022        PMID： 35419161      PMCID： PMC8995622          DOI： 10.1177/19418744211068913

Source DB:  PubMed          Journal:  Neurohospitalist        ISSN： 1941-8744


  12 in total

1.  Early detection of 5-FU-induced acute leukoencephalopathy on diffusion-weighted MRI.

Authors:  Reiko Akitake; Shin'ichi Miyamoto; Fumiyasu Nakamura; Takahiro Horimatsu; Yasumasa Ezoe; Manabu Muto; Tsutomu Chiba
Journal:  Jpn J Clin Oncol       Date:  2010-10-06       Impact factor: 3.019

Review 2.  Folates as adjuvants to anticancer agents: Chemical rationale and mechanism of action.

Authors:  Peter V Danenberg; Bengt Gustavsson; Patrick Johnston; Per Lindberg; Rudolf Moser; Elisabeth Odin; Godefridus J Peters; Nicholas Petrelli
Journal:  Crit Rev Oncol Hematol       Date:  2016-08-09       Impact factor: 6.312

3.  Orotate phosphoribosyltransferase gene polymorphism predicts toxicity in patients treated with bolus 5-fluorouracil regimen.

Authors:  Wataru Ichikawa; Takehiro Takahashi; Kenichi Suto; Yasutsuna Sasaki; Renzo Hirayama
Journal:  Clin Cancer Res       Date:  2006-07-01       Impact factor: 12.531

Review 4.  FDA Approval: Uridine Triacetate for the Treatment of Patients Following Fluorouracil or Capecitabine Overdose or Exhibiting Early-Onset Severe Toxicities Following Administration of These Drugs.

Authors:  Gwynn Ison; Julia A Beaver; W David McGuinn; Todd R Palmby; Jeannette Dinin; Rosane Charlab; Anshu Marathe; Runyan Jin; Qi Liu; Xiao Hong Chen; Xavier Ysern; Olen Stephens; Ge Bai; Yaning Wang; Sarah E Dorff; Joyce Cheng; Shenghui Tang; Rajeshwari Sridhara; William Pierce; Amy E McKee; Amna Ibrahim; Geoffrey Kim; Richard Pazdur
Journal:  Clin Cancer Res       Date:  2016-07-11       Impact factor: 12.531

5.  5-FU-induced leukoencephalopathy with reversible lesion of splenium of corpus callosum in a patient with colorectal cancer.

Authors:  Gyanendra Acharya; Maria T Cruz Carreras; Terry Wynne Rice
Journal:  BMJ Case Rep       Date:  2017-11-21

Review 6.  Dihydropyrimidine dehydrogenase deficiency: a pharmacogenetic defect causing severe adverse reactions to 5-fluorouracil-based chemotherapy.

Authors:  G B Morrison; A Bastian; T Dela Rosa; R B Diasio; C H Takimoto
Journal:  Oncol Nurs Forum       Date:  1997 Jan-Feb       Impact factor: 2.172

7.  High-dose 5-fluorouracil infusional therapy is associated with hyperammonaemia, lactic acidosis and encephalopathy.

Authors:  K H Yeh; A L Cheng
Journal:  Br J Cancer       Date:  1997       Impact factor: 7.640

8.  Severe neurotoxicity following 5-fluorouracil-based chemotherapy in a patient with dihydropyrimidine dehydrogenase deficiency.

Authors:  C H Takimoto; Z H Lu; R Zhang; M D Liang; L V Larson; L R Cantilena; J L Grem; C J Allegra; R B Diasio; E Chu
Journal:  Clin Cancer Res       Date:  1996-03       Impact factor: 12.531

9.  A case of neurotoxicity following 5-fluorouracil-based chemotherapy.

Authors:  Seung Seog Ki; Jin Mo Jeong; Seong Ho Kim; Sook Hyang Jeong; Jin Hyuk Lee; Chul Ju Han; You Cheol Kim; Jhin Oh Lee; Young Joon Hong
Journal:  Korean J Intern Med       Date:  2002-03       Impact factor: 2.884

10.  Pancytopenia and Severe Gastrointestinal Toxicities Associated with 5-Fluorouracil in a Patient with Thymidylate Synthase (TYMS) Polymorphism.

Authors:  Bo Wang; Shannon J Walsh; Muhammad W Saif
Journal:  Cureus       Date:  2016-09-21
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