Literature DB >> 3297043

GTP mobilization of Ca2+ from the endoplasmic reticulum of islets. Comparison with myo-inositol 1,4,5-trisphosphate.

B A Wolf, J Florholmen, J R Colca, M L McDaniel.   

Abstract

The effect of the guanine nucleotide GTP on Ca2+ release from the endoplasmic reticulum of digitonin-permeabilized islets was investigated. maximal and half-maximal Ca2+ release were observed at 5 microM- and 2.5 microM-GTP respectively. GTP caused a rapid release of Ca2+ from the endoplasmic reticulum, which was complete within 1 min. GTP-induced Ca2+ release was structurally specific and required the hydrolysis of GTP. The combination of maximal concentrations of GTP (10 microM) and myo-inositol 1,4,5-trisphosphate (IP3) (10 microM) resulted in an additive effect on Ca2+ release from the endoplasmic reticulum. GDP (100 microM), which inhibits GTP-induced Ca2+ release, did not affect IP3-induced Ca2+ release. Furthermore, GTP-induced Ca2+ release was not independent on submicromolar free Ca2+ concentrations, unlike IP3-induced Ca2+ release. These observations suggest that mechanistically GTP-induced Ca2+ release is different from IP3-induced Ca2+ release from the endoplasmic reticulum.

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Year:  1987        PMID： 3297043      PMCID： PMC1147675          DOI： 10.1042/bj2420137

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  25 in total

1.  GTP enhances inositol trisphosphate-stimulated Ca2+ release from rat liver microsomes.

Authors:  A P Dawson
Journal:  FEBS Lett       Date:  1985-06-03       Impact factor: 4.124

Review 2.  Regulation of insulin release by calcium.

Authors:  C B Wollheim; G W Sharp
Journal:  Physiol Rev       Date:  1981-10       Impact factor: 37.312

3.  A subcellular fractionation approach for studying insulin release mechanisms and calcium metabolism in islets of Langerhans.

Authors:  M L McDaniel; J R Colca; N Kotagal; P E Lacy
Journal:  Methods Enzymol       Date:  1983       Impact factor: 1.600

Review 4.  Cytosolic free Ca2+ in insulin secreting cells and its regulation by isolated organelles.

Authors:  M Prentki; C B Wollheim
Journal:  Experientia       Date:  1984-10-15

5.  Modulation of active Ca2+ uptake by the islet-cell endoplasmic reticulum.

Authors:  J R Colca; N Kotagal; P E Lacy; M L McDaniel
Journal:  Biochem J       Date:  1983-04-15       Impact factor: 3.857

6.  Rapid mobilization of Ca2+ from rat insulinoma microsomes by inositol-1,4,5-trisphosphate.

Authors:  M Prentki; T J Biden; D Janjic; R F Irvine; M J Berridge; C B Wollheim
Journal:  Nature       Date:  1984 Jun 7-13       Impact factor: 49.962

7.  The effect of inositol trisphosphate on Ca2+ fluxes in insulin-secreting tumor cells.

Authors:  S K Joseph; R J Williams; B E Corkey; F M Matschinsky; J R Williamson
Journal:  J Biol Chem       Date:  1984-11-10       Impact factor: 5.157

Review 8.  Inositol trisphosphate, a novel second messenger in cellular signal transduction.

Authors:  M J Berridge; R F Irvine
Journal:  Nature       Date:  1984 Nov 22-28       Impact factor: 49.962

9.  Inositol 1,4,5-trisphosphate mobilizes intracellular Ca2+ from permeabilized insulin-secreting cells.

Authors:  T J Biden; M Prentki; R F Irvine; M J Berridge; C B Wollheim
Journal:  Biochem J       Date:  1984-10-15       Impact factor: 3.857

10.  Active calcium uptake by islet-cell endoplasmic reticulum.

Authors:  J R Colca; J M McDonald; N Kotagal; C Patke; C J Fink; M H Greider; P E Lacy; M L McDaniel
Journal:  J Biol Chem       Date:  1982-06-25       Impact factor: 5.157
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  9 in total

1.  GTP-mediated Ca2+ release in rough endoplasmic reticulum. Correlation with a GTP-sensitive increase in membrane permeability.

Authors:  C V Nicchitta; S K Joseph; J R Williamson
Journal:  Biochem J       Date:  1987-12-15       Impact factor: 3.857

2.  The effect of limited proteolysis on GTP-dependent Ca2+ efflux and GTP-dependent fusion in rat liver microsomal vesicles.

Authors:  J G Comerford; A P Dawson
Journal:  Biochem J       Date:  1989-03-15       Impact factor: 3.857

3.  The mechanism of action of GTP on Ca2+ efflux from rat liver microsomal vesicles. Measurement of vesicle fusion by fluorescence energy transfer.

Authors:  J G Comerford; A P Dawson
Journal:  Biochem J       Date:  1988-01-01       Impact factor: 3.857

4.  Calcium entry into the inositol 1,4,5-trisphosphate-releasable calcium pool is mediated by a GTP-regulatory mechanism.

Authors:  J M Mullaney; M Yu; T K Ghosh; D L Gill
Journal:  Proc Natl Acad Sci U S A       Date:  1988-04       Impact factor: 11.205

5.  Thyrotropin-releasing hormone activates a [Ca2+]i-dependent K+ current in GH3 pituitary cells via Ins(1,4,5)P3-sensitive and Ins(1,4,5)P3-insensitive mechanisms.

Authors:  P Mollard; B Dufy; P Vacher; J L Barker; W Schlegel
Journal:  Biochem J       Date:  1990-06-01       Impact factor: 3.857

Review 6.  Is there evidence of a role of the phosphoinositol-cycle in the myocardium?

Authors:  D de Chaffoy de Courcelles
Journal:  Mol Cell Biochem       Date:  1989 Jun 27-Jul 24       Impact factor: 3.396

7.  GTP- and inositol 1,4,5-trisphosphate-induced release of 45Ca2+ from a membrane store co-localized with pancreatic-islet-cell plasma membrane.

Authors:  M E Dunlop; R G Larkins
Journal:  Biochem J       Date:  1988-07-01       Impact factor: 3.857

8.  Possible physiological role of guanosine triphosphate and inositol 1,4,5-trisphosphate in Ca2+ release in macrophages stimulated with chemotactic peptide.

Authors:  Y Kimura; M Hirata; T Hamachi; T Koga
Journal:  Biochem J       Date:  1988-01-15       Impact factor: 3.857

Review 9.  Signal transduction mechanisms involved in hormonal Ca2+ fluxes.

Authors:  J R Williamson; J R Monck
Journal:  Environ Health Perspect       Date:  1990-03       Impact factor: 9.031
  9 in total

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