Literature DB >> 35404386

Establishing spatial control over TORC1 signaling.

Oliver Schmidt1, Mariana E G de Araujo1.   

Abstract

Target-of-rapamycin complex 1 resides on lysosomes/vacuoles and additionally on signaling endosomes. Gao et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202109084) set out to define the molecular identity of signaling endosomes, along with players required for the formation and maintenance of this endosomal subpopulation.
© 2022 Schmidt and de Araujo.

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Year:  2022        PMID： 35404386      PMCID： PMC9007745          DOI： 10.1083/jcb.202203136

Source DB:  PubMed          Journal:  J Cell Biol        ISSN： 0021-9525            Impact factor:   10.539


  8 in total

1.  Spatially Distinct Pools of TORC1 Balance Protein Homeostasis.

Authors:  Riko Hatakeyama; Marie-Pierre Péli-Gulli; Zehan Hu; Malika Jaquenoud; Guillermo Miguel Garcia Osuna; Alessandro Sardu; Jörn Dengjel; Claudio De Virgilio
Journal:  Mol Cell       Date:  2018-12-06       Impact factor: 17.970

2.  Ivy1 is a negative regulator of Gtr-dependent TORC1 activation.

Authors:  Natalia V Varlakhanova; Bryan A Tornabene; Marijn G J Ford
Journal:  J Cell Sci       Date:  2018-09-07       Impact factor: 5.285

3.  The I-BAR protein Ivy1 is an effector of the Rab7 GTPase Ypt7 involved in vacuole membrane homeostasis.

Authors:  Johannes Numrich; Marie-Pierre Péli-Gulli; Henning Arlt; Alessandro Sardu; Janice Griffith; Tim Levine; Siegfried Engelbrecht-Vandré; Fulvio Reggiori; Claudio De Virgilio; Christian Ungermann
Journal:  J Cell Sci       Date:  2015-05-21       Impact factor: 5.285

4.  TORC1 Determines Fab1 Lipid Kinase Function at Signaling Endosomes and Vacuoles.

Authors:  Zilei Chen; Pedro Carpio Malia; Riko Hatakeyama; Raffaele Nicastro; Zehan Hu; Marie-Pierre Péli-Gulli; Jieqiong Gao; Taki Nishimura; Elja Eskes; Christopher J Stefan; Joris Winderickx; Jörn Dengjel; Claudio De Virgilio; Christian Ungermann
Journal:  Curr Biol       Date:  2020-11-05       Impact factor: 10.834

5.  mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation.

Authors:  Young-Mi Kim; Chang Hwa Jung; Minchul Seo; Eun Kyoung Kim; Ji-Man Park; Sun Sik Bae; Do-Hyung Kim
Journal:  Mol Cell       Date:  2014-12-18       Impact factor: 17.970

6.  Ultrastructural Morphometry Points to a New Role for LAMTOR2 in Regulating the Endo/Lysosomal System.

Authors:  Georg F Vogel; Hannes L Ebner; Mariana E G de Araujo; Thomas Schmiedinger; Oliver Eiter; Haymo Pircher; Karin Gutleben; Barbara Witting; David Teis; Lukas A Huber; Michael W Hess
Journal:  Traffic       Date:  2015-04-14       Impact factor: 6.215

Review 7.  The central moTOR of metabolism.

Authors:  Judith Simcox; Dudley W Lamming
Journal:  Dev Cell       Date:  2022-03-21       Impact factor: 12.270

8.  mTORC1 activity is supported by spatial association with focal adhesions.

Authors:  Yoana Rabanal-Ruiz; Adam Byron; Alexander Wirth; Ralitsa Madsen; Lucia Sedlackova; Graeme Hewitt; Glyn Nelson; Julian Stingele; Jimi C Wills; Tong Zhang; André Zeug; Reinhard Fässler; Bart Vanhaesebroeck; Oliver D K Maddocks; Evgeni Ponimaskin; Bernadette Carroll; Viktor I Korolchuk
Journal:  J Cell Biol       Date:  2021-05-03       Impact factor: 10.539
  8 in total

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