Literature DB >> 35316619

The central moTOR of metabolism.

Judith Simcox1, Dudley W Lamming2.   

Abstract

The protein kinase mechanistic target of rapamycin (mTOR) functions as a central regulator of metabolism, integrating diverse nutritional and hormonal cues to control anabolic processes, organismal physiology, and even aging. This review discusses the current state of knowledge regarding the regulation of mTOR signaling and the metabolic regulation of the four macromolecular building blocks of the cell: carbohydrate, nucleic acid, lipid, and protein by mTOR. We review the role of mTOR in the control of organismal physiology and aging through its action in key tissues and discuss the potential for clinical translation of mTOR inhibition for the treatment and prevention of diseases of aging. Published by Elsevier Inc.

Entities:  

Keywords:  amino acids; lipids; mTOR; mTORC1; mTORC2; metabolism; protein; rapamycin

Mesh：

Substances：

Year:  2022        PMID： 35316619      PMCID： PMC9004513          DOI： 10.1016/j.devcel.2022.02.024

Source DB:  PubMed          Journal:  Dev Cell        ISSN： 1534-5807            Impact factor:   12.270


  220 in total

1.  Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients.

Authors:  Matt Kaeberlein; R Wilson Powers; Kristan K Steffen; Eric A Westman; Di Hu; Nick Dang; Emily O Kerr; Kathryn T Kirkland; Stanley Fields; Brian K Kennedy
Journal:  Science       Date:  2005-11-18       Impact factor: 47.728

2.  Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.

Authors:  Takeshi Kaizuka; Taichi Hara; Noriko Oshiro; Ushio Kikkawa; Kazuyoshi Yonezawa; Kenji Takehana; Shun-Ichiro Iemura; Tohru Natsume; Noboru Mizushima
Journal:  J Biol Chem       Date:  2010-04-28       Impact factor: 5.157

3.  Dynamic Visualization of mTORC1 Activity in Living Cells.

Authors:  Xin Zhou; Terri L Clister; Pamela R Lowry; Marcus M Seldin; G William Wong; Jin Zhang
Journal:  Cell Rep       Date:  2015-03-12       Impact factor: 9.423

4.  The 3.2-Å resolution structure of human mTORC2.

Authors:  Alain Scaiola; Francesca Mangia; Stefan Imseng; Daniel Boehringer; Karolin Berneiser; Mitsugu Shimobayashi; Edward Stuttfeld; Michael N Hall; Nenad Ban; Timm Maier
Journal:  Sci Adv       Date:  2020-11-06       Impact factor: 14.136

5.  Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway.

Authors:  Pankaj Kapahi; Brian M Zid; Tony Harper; Daniel Koslover; Viveca Sapin; Seymour Benzer
Journal:  Curr Biol       Date:  2004-05-25       Impact factor: 10.834

6.  Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size.

Authors:  Yanyun Gu; Jill Lindner; Anil Kumar; Weiping Yuan; Mark A Magnuson
Journal:  Diabetes       Date:  2011-01-24       Impact factor: 9.461

7.  Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism.

Authors:  Rong Wang; Zhen Yu; Bharath Sunchu; James Shoaf; Ivana Dang; Stephanie Zhao; Kelsey Caples; Lynda Bradley; Laura M Beaver; Emily Ho; Christiane V Löhr; Viviana I Perez
Journal:  Aging Cell       Date:  2017-03-31       Impact factor: 9.304

8.  Raptor determines β-cell identity and plasticity independent of hyperglycemia in mice.

Authors:  Qinglei Yin; Qicheng Ni; Yichen Wang; Hongli Zhang; Wenyi Li; Aifang Nie; Shu Wang; Yanyun Gu; Qidi Wang; Guang Ning
Journal:  Nat Commun       Date:  2020-05-21       Impact factor: 14.919

9.  Methionine restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21.

Authors:  Emma K Lees; Elżbieta Król; Louise Grant; Kirsty Shearer; Cathy Wyse; Eleanor Moncur; Aleksandra S Bykowska; Nimesh Mody; Thomas W Gettys; Mirela Delibegovic
Journal:  Aging Cell       Date:  2014-06-17       Impact factor: 9.304

10.  Hypothalamic mTORC2 is essential for metabolic health and longevity.

Authors:  Karthikeyani Chellappa; Jacqueline A Brinkman; Sarmistha Mukherjee; Mark Morrison; Mohammed I Alotaibi; Kathryn A Carbajal; Amber L Alhadeff; Isaac J Perron; Rebecca Yao; Cole S Purdy; Denise M DeFelice; Matthew H Wakai; Jay Tomasiewicz; Amy Lin; Emma Meyer; Yajing Peng; Sebastian I Arriola Apelo; Luigi Puglielli; J Nicholas Betley; Georgios K Paschos; Joseph A Baur; Dudley W Lamming
Journal:  Aging Cell       Date:  2019-08-01       Impact factor: 9.304
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  4 in total

1.  Establishing spatial control over TORC1 signaling.

Authors:  Oliver Schmidt; Mariana E G de Araujo
Journal:  J Cell Biol       Date:  2022-04-09       Impact factor: 10.539

2.  Mechanistic Target of Rapamycin Complex 1: From a Nutrient Sensor to a Key Regulator of Metabolism and Health.

Authors:  Guoyan Wang; Lei Chen; Senlin Qin; Tingting Zhang; Junhu Yao; Yanglei Yi; Lu Deng
Journal:  Adv Nutr       Date:  2022-10-02       Impact factor: 11.567

3.  tRNA-Derived Fragment tRF-5009A Regulates Autophagy and Degeneration of Cartilage in Osteoarthritis via Targeting mTOR.

Authors:  Zengfa Deng; Dianbo Long; Hailong Liu; Yiyang Xu; Ruobing Xin; Hongyi Liao; Zhiwen Li; Ruiyun Li; Guping Mao; Ziji Zhang; Yan Kang
Journal:  Oxid Med Cell Longev       Date:  2022-08-05       Impact factor: 7.310

4.  Dengue activates mTORC2 signaling to counteract apoptosis and maximize viral replication.

Authors:  Christoph C Carter; Fred D Mast; Jean Paul Olivier; Natasha M Bourgeois; Alexis Kaushansky; John D Aitchison
Journal:  Front Cell Infect Microbiol       Date:  2022-09-12       Impact factor: 6.073
  4 in total

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