Kazumi Yoshizawa1, Ruka Kurono1, Haruka Sato1, Erika Ishijima1, Haruka Nasu1, Nurfarhana Ferdaos1,2, Hidetaka Suzuki1,3, Kenichi Negishi4. 1. Laboratory of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences,Tokyo University of Science, Chiba, Japan. 2. Department of Pharmacology and Chemistry, Faculty of Pharmacy,Universiti Teknologi MARA, Selangor, Malaysia. 3. Division of Pharmacy, National Cancer Center Hospital East, Chiba, Japan. 4. Laboratory of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan.
Abstract
Background/Aim: Fatigue is the most common symptom in patients with cancer undergoing radiation therapy or cancer chemotherapy. However, cancer-related fatigue remains undertreated and poorly understood. Materials and Methods: Mice were administered a single dose of cisplatin (10 mg/kg, intraperitoneally) or saline (as a control) and then treated with sucrose, fructose, glucose (each at 500 or 5,000 mg/kg, orally), or saline (control) daily for 4 days. cisplatin-induced fatigue-like behavior was investigated by assessment of running activity on a treadmill. The influence of glucose intake on tumor growth was also examined in Lewis lung carcinoma (LLC)-bearing mice. Results: Administration of sucrose and glucose improved cisplatin-induced fatigue-like behavior in mice, whereas administration of fructose showed only slight antifatigue effects. Although glucose-fed mice showed increased tumor growth, this was balanced out by the powerful cytotoxicity of cisplatin. Conclusion: Sucrose, and especially glucose, may improve patient quality of life during treatment with anticancer agents by preventing fatigue without interfering with the antitumor effects of cisplatin. Copyright 2021, International Institute of Anticancer Research.
Background/Aim: Fatigue is the most common symptom in patients with cancer undergoing radiation therapy or cancer chemotherapy. However, cancer-related fatigue remains undertreated and poorly understood. Materials and Methods: Mice were administered a single dose of cisplatin (10 mg/kg, intraperitoneally) or saline (as a control) and then treated with sucrose, fructose, glucose (each at 500 or 5,000 mg/kg, orally), or saline (control) daily for 4 days. cisplatin-induced fatigue-like behavior was investigated by assessment of running activity on a treadmill. The influence of glucose intake on tumor growth was also examined in Lewis lung carcinoma (LLC)-bearing mice. Results: Administration of sucrose and glucose improved cisplatin-induced fatigue-like behavior in mice, whereas administration of fructose showed only slight antifatigue effects. Although glucose-fed mice showed increased tumor growth, this was balanced out by the powerful cytotoxicity of cisplatin. Conclusion: Sucrose, and especially glucose, may improve patient quality of life during treatment with anticancer agents by preventing fatigue without interfering with the antitumor effects of cisplatin. Copyright 2021, International Institute of Anticancer Research.
Authors: Samir Softic; Manoj K Gupta; Guo-Xiao Wang; Shiho Fujisaka; Brian T O'Neill; Tata Nageswara Rao; Jennifer Willoughby; Carole Harbison; Kevin Fitzgerald; Olga Ilkayeva; Christopher B Newgard; David E Cohen; C Ronald Kahn Journal: J Clin Invest Date: 2017-10-03 Impact factor: 14.808