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Literature DB >> 35393664

Targeting the cell's gatekeepers for novel drug discovery.

Gary J Stephens¹, Arun K Shukla².

Abstract

Entities: Chemical

Mesh：
Drug Discovery

Year: 2022 PMID： 35393664 PMCID： PMC7612873 DOI： 10.1111/bph.15831

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 9.473

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References

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11 in total

1. Heterologous expression of concatenated nicotinic ACh receptors: Pros and cons of subunit concatenation and recommendations for construct designs.

Authors: Vivian Wan Yu Liao; Ali Saad Kusay; Thomas Balle; Philip Kiaer Ahring
Journal: Br J Pharmacol Date: 2020-08-05 Impact factor: 8.739

Review 2. Temperature-sensitive transient receptor potential vanilloid channels: structural insights into ligand-dependent activation.

Authors: Lejla Zubcevic
Journal: Br J Pharmacol Date: 2020-11-26 Impact factor: 9.473

Review 3. Emerging insights into the structure and function of ionotropic glutamate delta receptors.

Authors: Ananth Prasad Burada; Rajesh Vinnakota; Pratibha Bharti; Priyanka Dutta; Neelima Dubey; Janesh Kumar
Journal: Br J Pharmacol Date: 2020-12-07 Impact factor: 9.473

Review 4. Structure-based survey of ligand binding in the human insulin receptor.

Authors: Lokender Kumar; Whitney Vizgaudis; Judith Klein-Seetharaman
Journal: Br J Pharmacol Date: 2022-02-04 Impact factor: 9.473

5. Pharmacological properties of TRPM3 isoforms are determined by the length of the pore loop.

Authors: Katharina Held; Vincenzo Davide Aloi; Ana Cristina Nogueira Freitas; Annelies Janssens; Andrei Segal; Julia Przibilla; Stephan Ernst Philipp; Yu Tian Wang; Thomas Voets; Joris Vriens
Journal: Br J Pharmacol Date: 2020-08-28 Impact factor: 9.473

Review 10. Fifteen years of Na_V 1.7 channels as an analgesic target: Why has excellent in vitro pharmacology not translated into in vivo analgesic efficacy?

Authors: David A Eagles; Chun Yuen Chow; Glenn F King
Journal: Br J Pharmacol Date: 2020-12-18 Impact factor: 9.473

Targeting the cell's gatekeepers for novel drug discovery.

1. Heterologous expression of concatenated nicotinic ACh receptors: Pros and cons of subunit concatenation and recommendations for construct designs.

Review 2. Temperature-sensitive transient receptor potential vanilloid channels: structural insights into ligand-dependent activation.

Review 3. Emerging insights into the structure and function of ionotropic glutamate delta receptors.

Review 4. Structure-based survey of ligand binding in the human insulin receptor.

5. Pharmacological properties of TRPM3 isoforms are determined by the length of the pore loop.

Review 6. Adenosine A_2A receptor antagonists: from caffeine to selective non-xanthines.

Review 7. Therapeutic validation of an orphan G protein-coupled receptor: The case of GPR84.

8. Structural determinants of TRPV4 inhibition and identification of new antagonists with antiviral activity.

9. Structural basis of AMPA receptor inhibition by trans-4-butylcyclohexane carboxylic acid.

Review 10. Fifteen years of Na_V 1.7 channels as an analgesic target: Why has excellent in vitro pharmacology not translated into in vivo analgesic efficacy?

Targeting the cell's gatekeepers for novel drug discovery.

1. Heterologous expression of concatenated nicotinic ACh receptors: Pros and cons of subunit concatenation and recommendations for construct designs.

Review 2. Temperature-sensitive transient receptor potential vanilloid channels: structural insights into ligand-dependent activation.

Review 3. Emerging insights into the structure and function of ionotropic glutamate delta receptors.

Review 4. Structure-based survey of ligand binding in the human insulin receptor.

5. Pharmacological properties of TRPM3 isoforms are determined by the length of the pore loop.

Review 6. Adenosine A2A receptor antagonists: from caffeine to selective non-xanthines.

Review 7. Therapeutic validation of an orphan G protein-coupled receptor: The case of GPR84.

8. Structural determinants of TRPV4 inhibition and identification of new antagonists with antiviral activity.

9. Structural basis of AMPA receptor inhibition by trans-4-butylcyclohexane carboxylic acid.

Review 10. Fifteen years of NaV 1.7 channels as an analgesic target: Why has excellent in vitro pharmacology not translated into in vivo analgesic efficacy?

Review 6. Adenosine A_2A receptor antagonists: from caffeine to selective non-xanthines.

Review 10. Fifteen years of Na_V 1.7 channels as an analgesic target: Why has excellent in vitro pharmacology not translated into in vivo analgesic efficacy?