Chi Thi-Du Tran1,2,3, Mai Vu-Tuyet Nguyen1, Mo Thi Tran1, Thuy Thi-Van Tuong1, Quang Hong Tran1, Linh Cu Le2, Huong Thi-Thu Pham4, Nam Chi Bui4, Hien Huy Vu4, Tu Thi-Cam Nguyen4, Phuong Que Ta4, Hien Thi-Thu Ha5, Dung Tuan Trinh5,6, Hanh Thi-My Bui5, Dien Quang Trinh5, Khanh Van Nguyen5, Song Huu Le7, Khien Van Vu8, Thuan Van Tran9,10, Huong Thi-Thanh Tran10, Martha J Shrubsole11, Fei Ye11, Qiuyin Cai11, Wei Zheng11, Paolo Boffetta12,13, Xiao-Ou Shu11, Hung N Luu14,15. 1. Vietnam Colorectal Cancer and Polyps Research Program, Vinmec Healthcare System, Hanoi, Vietnam. 2. College of Health Sciences, VinUniversity (VinUni), Hanoi, Vietnam. 3. Center of Applied Sciences, Regenerative Medicine and Advanced Technology (CARA), Vinmec Healthcare System, Hanoi, Vietnam. 4. Department of Gastroenterology, Vinmec International Hospital at Times City, Vinmec Healthcare System, Hanoi, Vietnam. 5. Department of Histopathology, Vinmec International Hospital at Times City, Vinmec Healthcare System, Hanoi, Vietnam. 6. Department of Histopathology, Tam Anh General Hospital, Hanoi, Vietnam. 7. Center of Molecular and Genetic Research, 108 Hospital, Hanoi, Vietnam. 8. Department of Gastroenterology, 108 Hospital, Hanoi, Vietnam. 9. Vietnam Ministry of Health, Hanoi, Vietnam. 10. Vietnam National Cancer Institute, Vietnam National Cancer Hospital, Hanoi, Vietnam. 11. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA. 12. Stony Brook Cancer Center, Stony Brooke University, Stony Brook, NY, USA. 13. Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy. 14. UPMC Hillman Cancer Center, University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, USA. 15. Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Abstract
BACKGROUND: Colorectal cancer is a leading cancer incidence and cause of death worldwide and in Vietnam. Although screening is considered an effective measure to prevent and control colorectal cancer, there is no such effort in Vietnam. METHODS: Between 01 January 2018 and 31 October 2019, a population-based colorectal cancer screening program was conducted in Hanoi, Vietnam. A health advocacy campaign and follow-up phone calls were used to enroll residents aged ≥40 years old to complete an immunochemical-fecal occult blood testing. Positive immunochemical-fecal occult blood testing was followed by a colonoscopy. We also conducted a systematic review of the colorectal cancer screening programs in the Asia-Pacific region that used similar approach by searching Ovid Medline and PubMed databases. RESULTS: During study period, 103 542 individuals among 672 742 eligible residents attended the screening of whom 81.5% participants finished immunochemical-fecal occult blood testing test and the positive rate was 6.1%. The coverage rate for immunochemical-fecal occult blood testing test was 11.9%. Among 2278 individuals who underwent colonoscopy, 3.5% were histologically diagnosed with cancer, 17.8% with advanced adenomas, and 23.1% with non-advanced adenomas. Males had significantly higher detection rate of advanced adenomas, cancer or ≥ two polyps/tumor than females (P < 0.0001). The systematic review showed that in two-step modality (i.e. immunochemical-fecal occult blood testing/fecal immunochemical test and colonoscopy), the test positive was from 4.1 to 10.6%. Once colonoscopy was performed subsequently, the rate of cancer among positive participants was from 1.7 to 16.4% and that of advanced adenomas was from 7.1 to 23.1%. CONCLUSION: We showed that the two-step modality is a promising strategy for colorectal cancer screening in Vietnam that might apply to similar settings with limited resources.
BACKGROUND: Colorectal cancer is a leading cancer incidence and cause of death worldwide and in Vietnam. Although screening is considered an effective measure to prevent and control colorectal cancer, there is no such effort in Vietnam. METHODS: Between 01 January 2018 and 31 October 2019, a population-based colorectal cancer screening program was conducted in Hanoi, Vietnam. A health advocacy campaign and follow-up phone calls were used to enroll residents aged ≥40 years old to complete an immunochemical-fecal occult blood testing. Positive immunochemical-fecal occult blood testing was followed by a colonoscopy. We also conducted a systematic review of the colorectal cancer screening programs in the Asia-Pacific region that used similar approach by searching Ovid Medline and PubMed databases. RESULTS: During study period, 103 542 individuals among 672 742 eligible residents attended the screening of whom 81.5% participants finished immunochemical-fecal occult blood testing test and the positive rate was 6.1%. The coverage rate for immunochemical-fecal occult blood testing test was 11.9%. Among 2278 individuals who underwent colonoscopy, 3.5% were histologically diagnosed with cancer, 17.8% with advanced adenomas, and 23.1% with non-advanced adenomas. Males had significantly higher detection rate of advanced adenomas, cancer or ≥ two polyps/tumor than females (P < 0.0001). The systematic review showed that in two-step modality (i.e. immunochemical-fecal occult blood testing/fecal immunochemical test and colonoscopy), the test positive was from 4.1 to 10.6%. Once colonoscopy was performed subsequently, the rate of cancer among positive participants was from 1.7 to 16.4% and that of advanced adenomas was from 7.1 to 23.1%. CONCLUSION: We showed that the two-step modality is a promising strategy for colorectal cancer screening in Vietnam that might apply to similar settings with limited resources.
Authors: Martin C S Wong; Jessica Y L Ching; Victor C W Chan; Thomas Y T Lam; Jeffrey P Shum; Arthur K C Luk; Sunny S H Wong; Siew C Ng; Simon S M Ng; Justin C Y Wu; Francis K L Chan; Joseph J Y Sung Journal: Clin Gastroenterol Hepatol Date: 2015-02-24 Impact factor: 11.382
Authors: Chang Kyun Lee; Kui Son Choi; Chang Soo Eun; Dong-Il Park; Dong Soo Han; Minjoo Yoon; Mina Suh; Jae Kwan Jun Journal: Cancer Res Treat Date: 2017-02-24 Impact factor: 4.679