| Literature DB >> 35379992 |
Céline Bellenguez1, Fahri Küçükali2,3,4, Iris E Jansen5,6, Luca Kleineidam7,8,9, Sonia Moreno-Grau10,11, Najaf Amin12,13, Adam C Naj14,15, Rafael Campos-Martin8, Mikko Hiltunen16, Kristel Sleegers2,3,4, Gerard D Schellenberg15, Cornelia M van Duijn12,13, Rebecca Sims17, Wiesje M van der Flier5, Agustín Ruiz10,11, Alfredo Ramirez7,8,9,18,19, Jean-Charles Lambert20, Benjamin Grenier-Boley21, Victor Andrade7,8, Peter A Holmans17, Anne Boland22, Vincent Damotte21, Sven J van der Lee5,23, Marcos R Costa21,16, Teemu Kuulasmaa24, Qiong Yang25,26, Itziar de Rojas10,11, Joshua C Bis27, Amber Yaqub12, Ivana Prokic12, Julien Chapuis21, Shahzad Ahmad12,28, Vilmantas Giedraitis29, Dag Aarsland30,31, Pablo Garcia-Gonzalez10,11, Carla Abdelnour10,11, Emilio Alarcón-Martín10,32, Daniel Alcolea11,33, Montserrat Alegret10,11, Ignacio Alvarez34,35, Victoria Álvarez36,37, Nicola J Armstrong38, Anthoula Tsolaki39,40, Carmen Antúnez41, Ildebrando Appollonio42,43, Marina Arcaro44, Silvana Archetti45, Alfonso Arias Pastor46,47, Beatrice Arosio48,49, Lavinia Athanasiu50, Henri Bailly51, Nerisa Banaj52, Miquel Baquero53, Sandra Barral54,55,56, Alexa Beiser24,57, Ana Belén Pastor58, Jennifer E Below59, Penelope Benchek60,61, Luisa Benussi62, Claudine Berr63, Céline Besse22, Valentina Bessi64,65, Giuliano Binetti62,66, Alessandra Bizarro67, Rafael Blesa11,33, Mercè Boada10,11, Eric Boerwinkle68,69, Barbara Borroni70, Silvia Boschi71, Paola Bossù72, Geir Bråthen73,74, Jan Bressler68,75, Catherine Bresner17, Henry Brodaty38,76, Keeley J Brookes77, Luis Ignacio Brusco78,79,80, Dolores Buiza-Rueda11,81, Katharina Bûrger82,83, Vanessa Burholt84,85, William S Bush86, Miguel Calero10,58,87, Laura B Cantwell88, Geneviève Chene89,90, Jaeyoon Chung91, Michael L Cuccaro92, Ángel Carracedo93,94, Roberta Cecchetti95, Laura Cervera-Carles11,33, Camille Charbonnier96, Hung-Hsin Chen97, Caterina Chillotti98, Simona Ciccone49, Jurgen A H R Claassen99, Christopher Clark100, Elisa Conti42, Anaïs Corma-Gómez101, Emanuele Costantini102, Carlo Custodero103, Delphine Daian22, Maria Carolina Dalmasso8, Antonio Daniele102, Efthimios Dardiotis104, Jean-François Dartigues105, Peter Paul de Deyn106, Katia de Paiva Lopes107,108,109,110, Lot D de Witte110, Stéphanie Debette105, Jürgen Deckert111, Teodoro Del Ser58, Nicola Denning112, Anita DeStefano24,25,113, Martin Dichgans82,114, Janine Diehl-Schmid115, Mónica Diez-Fairen34,35, Paolo Dionigi Rossi49, Srdjan Djurovic50, Emmanuelle Duron51, Emrah Düzel116,117, Carole Dufouil89,90, Gudny Eiriksdottir118, Sebastiaan Engelborghs119,120,121,122, Valentina Escott-Price15,112, Ana Espinosa10,11, Michael Ewers82,83, Kelley M Faber123, Tagliavini Fabrizio124, Sune Fallgaard Nielsen125, David W Fardo126, Lucia Farotti127, Chiara Fenoglio128, Marta Fernández-Fuertes101, Raffaele Ferrari129,130, Catarina B Ferreira131, Evelyn Ferri49, Bertrand Fin22, Peter Fischer132, Tormod Fladby133, Klaus Fließbach8,9, Bernard Fongang18, Myriam Fornage74,75, Juan Fortea11,33, Tatiana M Foroud123, Silvia Fostinelli62, Nick C Fox134, Emlio Franco-Macías135, María J Bullido11,136,137, Ana Frank-García11,136,138, Lutz Froelich139, Brian Fulton-Howard140, Daniela Galimberti44,128, Jose Maria García-Alberca11,141, Pablo García-González10, Sebastian Garcia-Madrona142, Guillermo Garcia-Ribas142, Roberta Ghidoni62, Ina Giegling143, Giaccone Giorgio124, Alison M Goate140, Oliver Goldhardt115, Duber Gomez-Fonseca144, Antonio González-Pérez145, Caroline Graff146,147, Giulia Grande148, Emma Green149, Timo Grimmer115, Edna Grünblatt150,151,152, Michelle Grunin61, Vilmundur Gudnason153, Tamar Guetta-Baranes154, Annakaisa Haapasalo155, Georgios Hadjigeorgiou156, Jonathan L Haines86, Kara L Hamilton-Nelson157, Harald Hampel158, Olivier Hanon51, John Hardy130, Annette M Hartmann143, Lucrezia Hausner139, Janet Harwood17, Stefanie Heilmann-Heimbach159, Seppo Helisalmi160,161, Michael T Heneka7,9, Isabel Hernández10,11, Martin J Herrmann111, Per Hoffmann159, Clive Holmes162, Henne Holstege5,23, Raquel Huerto Vilas46,47, Marc Hulsman5,23, Jack Humphrey107,108,109,163, Geert Jan Biessels164, Xueqiu Jian18, Charlotte Johansson146, Gyungah R Jun91, Yuriko Kastumata165, John Kauwe166, Patrick G Kehoe167, Lena Kilander25, Anne Kinhult Ståhlbom146, Miia Kivipelto168,169,170,171, Anne Koivisto160,172,173, Johannes Kornhuber174, Mary H Kosmidis175, Walter A Kukull176, Pavel P Kuksa15, Brian W Kunkle156, Amanda B Kuzma88, Carmen Lage11,177, Erika J Laukka148,178, Lenore Launer179,180, Alessandra Lauria67, Chien-Yueh Lee15, Jenni Lehtisalo160,181, Ondrej Lerch182,183, Alberto Lleó11,33, William Longstreth184, Oscar Lopez26, Adolfo Lopez de Munain11,185, Seth Love167, Malin Löwemark25, Lauren Luckcuck17, Kathryn L Lunetta24, Yiyi Ma23,186, Juan Macías101, Catherine A MacLeod187, Wolfgang Maier7,9, Francesca Mangialasche168, Marco Spallazzi55, Marta Marquié10,11, Rachel Marshall17, Eden R Martin157, Angel Martín Montes11,136,138, Carmen Martínez Rodríguez37, Carlo Masullo188, Richard Mayeux54,189, Simon Mead190, Patrizia Mecocci95, Miguel Medina11,58, Alun Meggy112, Shima Mehrabian56, Silvia Mendoza141, Manuel Menéndez-González37, Pablo Mir11,191, Susanne Moebus192, Merel Mol81, Laura Molina-Porcel193,194, Laura Montrreal10, Laura Morelli195, Fermin Moreno11,185, Kevin Morgan196, Thomas Mosley197, Markus M Nöthen159, Carolina Muchnik78,198, Shubhabrata Mukherjee199, Benedetta Nacmias64,200, Tiia Ngandu181, Gael Nicolas96, Børge G Nordestgaard125,201, Robert Olaso22, Adelina Orellana10,11, Michela Orsini102, Gemma Ortega10,11, Alessandro Padovani69, Caffarra Paolo202, Goran Papenberg148, Lucilla Parnetti127, Florence Pasquier203, Pau Pastor34,35, Gina Peloso24,57, Alba Pérez-Cordón10, Jordi Pérez-Tur11,204,205, Pierre Pericard206, Oliver Peters207,208, Yolande A L Pijnenburg5, Juan A Pineda101, Gerard Piñol-Ripoll46,47, Claudia Pisanu209, Thomas Polak111, Julius Popp210,211,212, Danielle Posthuma6, Josef Priller208,213, Raquel Puerta10, Olivier Quenez96, Inés Quintela93, Jesper Qvist Thomassen214, Alberto Rábano11,58, Innocenzo Rainero70, Farid Rajabli157, Inez Ramakers215, Luis M Real101,216, Marcel J T Reinders217, Christiane Reitz189,217,218, Dolly Reyes-Dumeyer186,218, Perry Ridge219, Steffi Riedel-Heller220, Peter Riederer221, Natalia Roberto10, Eloy Rodriguez-Rodriguez11,177, Arvid Rongve222,223, Irene Rosas Allende36,37, Maitée Rosende-Roca10,11, Jose Luis Royo224, Elisa Rubino225, Dan Rujescu143, María Eugenia Sáez145, Paraskevi Sakka226, Ingvild Saltvedt73,227, Ángela Sanabria10,11, María Bernal Sánchez-Arjona135, Florentino Sanchez-Garcia228, Pascual Sánchez Juan11,177, Raquel Sánchez-Valle229, Sigrid B Sando72,73, Chloé Sarnowski68, Claudia L Satizabal25,113,18, Michela Scamosci95, Nikolaos Scarmeas54,230, Elio Scarpini44,128, Philip Scheltens5, Norbert Scherbaum231, Martin Scherer232, Matthias Schmid9,233, Anja Schneider7,9, Jonathan M Schott134, Geir Selbæk133,234, Davide Seripa235, Manuel Serrano236, Jin Sha14, Alexey A Shadrin50, Olivia Skrobot167, Susan Slifer157, Gijsje J L Snijders110, Hilkka Soininen160, Vincenzo Solfrizzi103, Alina Solomon160,168, Yeunjoo Song61, Sandro Sorbi64,200, Oscar Sotolongo-Grau10, Gianfranco Spalletta52, Annika Spottke9,237, Alessio Squassina238, Eystein Stordal239, Juan Pablo Tartan10, Lluís Tárraga10,11, Niccolo Tesí5,23, Anbupalam Thalamuthu38, Tegos Thomas39,40, Giuseppe Tosto54,186, Latchezar Traykov56, Lucio Tremolizzo42,43, Anne Tybjærg-Hansen201,214, Andre Uitterlinden240, Abbe Ullgren146, Ingun Ulstein234, Sergi Valero10,11, Otto Valladares15, Christine Van Broeckhoven2,3,241, Jeffery Vance92, Badri N Vardarajan54, Aad van der Lugt242, Jasper Van Dongen2,3,4, Jeroen van Rooij81,242, John van Swieten81, Rik Vandenberghe243,244, Frans Verhey215, Jean-Sébastien Vidal51, Jonathan Vogelgsang245,246, Martin Vyhnalek182,183, Michael Wagner7,9, David Wallon247, Li-San Wang15, Ruiqi Wang24,25, Leonie Weinhold233, Jens Wiltfang245,248,249, Gill Windle187, Bob Woods187, Mary Yannakoulia250, Habil Zare18, Yi Zhao15, Xiaoling Zhang251, Congcong Zhu251, Miren Zulaica11,252, Lindsay A Farrer24,91,113, Bruce M Psaty26,88,253, Mohsen Ghanbari12, Towfique Raj107,108,109,163, Perminder Sachdev38, Karen Mather38, Frank Jessen7,9, M Arfan Ikram12, Alexandre de Mendonça131, Jakub Hort180,182, Magda Tsolaki39,40, Margaret A Pericak-Vance155, Philippe Amouyel21, Julie Williams17,112, Ruth Frikke-Schmidt201,214, Jordi Clarimon11,33, Jean-François Deleuze22, Giacomina Rossi124, Sudha Seshadri25,113,18, Ole A Andreassen50, Martin Ingelsson29.
Abstract
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele.Entities:
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Year: 2022 PMID： 35379992 PMCID： PMC9005347 DOI： 10.1038/s41588-022-01024-z
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 41.307