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Literature DB >> 3537700

A human Ki-ras oncogene encodes two transforming p21 proteins.

Abstract

The human Ki-ras gene was previously reported to contain two alternative fourth exons which encode two distinct p21 proteins differing only at their carboxy termini. The present study shows that either p21 protein is able on its own to transform NIH 3T3 cells to a tumorigenic state.

Entities: Gene Species

Mesh：

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Year: 1986 PMID： 3537700 PMCID： PMC367646 DOI： 10.1128/mcb.6.4.1326-1328.1986

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

11 in total

1. Activation of a human c-K-ras oncogene.

Authors: F Yamamoto; M Perucho
Journal: Nucleic Acids Res Date: 1984-12-11 Impact factor: 16.971

2. Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

Authors: P J Southern; P Berg
Journal: J Mol Appl Genet Date: 1982

3. Isolation of transforming sequences of two human lung carcinomas: structural and functional analysis of the activated c-K-ras oncogenes.

Authors: H Nakano; F Yamamoto; C Neville; D Evans; T Mizuno; M Perucho
Journal: Proc Natl Acad Sci U S A Date: 1984-01 Impact factor: 11.205

4. The p21 ras C-terminus is required for transformation and membrane association.

Authors: B M Willumsen; A Christensen; N L Hubbert; A G Papageorge; D R Lowy
Journal: Nature Date: 1984 Aug 16-22 Impact factor: 49.962

5. Malignant activation of a K-ras oncogene in lung carcinoma but not in normal tissue of the same patient.

Authors: E Santos; D Martin-Zanca; E P Reddy; M A Pierotti; G Della Porta; M Barbacid
Journal: Science Date: 1984-02-17 Impact factor: 47.728

6. Monoclonal antibodies to the p21 products of the transforming gene of Harvey murine sarcoma virus and of the cellular ras gene family.

Authors: M E Furth; L J Davis; B Fleurdelys; E M Scolnick
Journal: J Virol Date: 1982-07 Impact factor: 5.103

A human Ki-ras oncogene encodes two transforming p21 proteins.

1. Activation of a human c-K-ras oncogene.

2. Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

3. Isolation of transforming sequences of two human lung carcinomas: structural and functional analysis of the activated c-K-ras oncogenes.

4. The p21 ras C-terminus is required for transformation and membrane association.

5. Malignant activation of a K-ras oncogene in lung carcinoma but not in normal tissue of the same patient.

6. Monoclonal antibodies to the p21 products of the transforming gene of Harvey murine sarcoma virus and of the cellular ras gene family.

7. Cellular transforming genes.

8. Human colon carcinoma Ki-ras2 oncogene and its corresponding proto-oncogene.

9. A cDNA cloning vector that permits expression of cDNA inserts in mammalian cells.

10. Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1.

1. p21ras-induced responsiveness of phosphatidylinositol turnover to bradykinin is a receptor number effect.