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Literature DB >> 35368574

TRPM2 Plays a Minor Role in AKI and Kidney Fibrosis.

Yu Kurata¹, Tetsuhiro Tanaka¹, Hana Cernecka², Frank Eitner², Masaomi Nangaku¹.

Abstract

TRPM2 is a Ca2+-permeable cationic channel and serves as an oxidative stress sensor.TRPM2 deletion was harmful in renal ischemia-reperfusion injury, whereas TRPM2 deletion mitigated kidney fibrosis.Our findings suggest the role of TRPM2 in kidney diseases is context dependent.

Entities: Chemical

Keywords: TRPM2; acute kidney injury; acute kidney injury and ICU nephrology; basic science; chronic kidney disease; fibrosis; ischemia-reperfusion injury

Mesh：

Substances：

Year: 2021 PMID： 35368574 PMCID： PMC8967600 DOI： 10.34067/KID.0005492021

Source DB: PubMed Journal: Kidney360 ISSN： 2641-7650

15 in total

1. Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels.

Authors: Anne-Laure Perraud; Christina L Takanishi; Betty Shen; Shin Kang; Megan K Smith; Carsten Schmitz; Heather M Knowles; Dana Ferraris; Weixing Li; Jie Zhang; Barry L Stoddard; Andrew M Scharenberg
Journal: J Biol Chem Date: 2004-11-23 Impact factor: 5.157

2. 8-Br-cADPR, a TRPM2 ion channel antagonist, inhibits renal ischemia-reperfusion injury.

Authors: Ersen Eraslan; Ayhan Tanyeli; Elif Polat; Elif Polat
Journal: J Cell Physiol Date: 2018-09-07 Impact factor: 6.384

Review 3. Roles of TRPM2 in oxidative stress.

Authors: Nobuaki Takahashi; Daisuke Kozai; Ryohei Kobayashi; Maximilian Ebert; Yasuo Mori
Journal: Cell Calcium Date: 2011-05-25 Impact factor: 6.817

4. TRPM2 mediates ischemic kidney injury and oxidant stress through RAC1.

Authors: Guofeng Gao; Weiwei Wang; Raghu K Tadagavadi; Nicole E Briley; Michael I Love; Barbara A Miller; W Brian Reeves
Journal: J Clin Invest Date: 2014-10-08 Impact factor: 14.808

Review 5. Oxidative stress in obstructive nephropathy.

Authors: Amélie Dendooven; David A Ishola; Tri Q Nguyen; Dionne M Van der Giezen; Robbert Jan Kok; Roel Goldschmeding; Jaap A Joles
Journal: Int J Exp Pathol Date: 2010-08-27 Impact factor: 1.925

6. The second member of transient receptor potential-melastatin channel family protects hearts from ischemia-reperfusion injury.

Authors: Barbara A Miller; JuFang Wang; Iwona Hirschler-Laszkiewicz; Erhe Gao; Jianliang Song; Xue-Qian Zhang; Walter J Koch; Muniswamy Madesh; Karthik Mallilankaraman; Tongda Gu; Shu-jen Chen; Kerry Keefer; Kathleen Conrad; Arthur M Feldman; Joseph Y Cheung
Journal: Am J Physiol Heart Circ Physiol Date: 2013-02-01 Impact factor: 4.733

7. Neutrophil TRPM2 channels are implicated in the exacerbation of myocardial ischaemia/reperfusion injury.

Authors: Toshihito Hiroi; Teruaki Wajima; Takaharu Negoro; Masakazu Ishii; Yasuko Nakano; Yuji Kiuchi; Yasuo Mori; Shunichi Shimizu
Journal: Cardiovasc Res Date: 2012-11-05 Impact factor: 10.787

8. TRPM2 channels protect against cardiac ischemia-reperfusion injury: role of mitochondria.

Authors: Barbara A Miller; Nicholas E Hoffman; Salim Merali; Xue-Qian Zhang; JuFang Wang; Sudarsan Rajan; Santhanam Shanmughapriya; Erhe Gao; Carlos A Barrero; Karthik Mallilankaraman; Jianliang Song; Tongda Gu; Iwona Hirschler-Laszkiewicz; Walter J Koch; Arthur M Feldman; Muniswamy Madesh; Joseph Y Cheung
Journal: J Biol Chem Date: 2014-02-03 Impact factor: 5.157